Target-based compound library design and synthesis

Drug Discovery Today: TARGETS

Volumn 3, Issue 2, 2004, Pages 48-50

  Player, Mark R ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

Chemical Biology; Drug Discovery; drug targets; Genetics; microwave synthesis applications; solid phase reagents; solution phase library; target based library design; Techniques Methods

Indexed keywords

CATALYST; GENE LIBRARY; GENE SYNTHESIS; GENE TARGETING; GENETIC SCREENING; HYDROGEN BOND; SHORT SURVEY; X RAY CRYSTALLOGRAPHY;

EID: 12344257734     PISSN: 17418372     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1741-8372(04)02402-8     Document Type: Letter

References (5)

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2. Nishihata Y., et al. Self-regeneration of a Pd-perovskite catalyst for automotive emission control. Nature. 418:2002;164-167
3. Congreve M., et al. A 'rule of three' for fragment-based lead discovery? Drug Discov. Today. 8:2003;876-877
4. Guller R., et al. Piperidine-renin inhibitors: compounds with improved physiochemical properties. Bioorg. Med. Chem. Lett. 9:1999;1403-1408
5. Bursavich M.G., et al. From peptides to non-peptide peptidomimetics: design and synthesis of new piperidine inhibitors of aspartic peptidases. Org. Lett. 3:2001;2317-2320