Scale-up of stirring as foam disruption (SAFD) to industrial scale

Journal of Industrial Microbiology and Biotechnology

Volumn 30, Issue 2, 2003, Pages 118-128

  Hoeks, Frans W J M M ^a   Boon, Lotte A ^b   Studer, Fabian ^a   Wolff, Menno O ^c   Van Der Schot, Freija ^c   Vrabél, Peter ^c   Van Der Lans, Rob G J M ^c   Bujalski, Waldemar ^b   Manelius, Åsa ^d   Blomsten, Gustav ^e   Hjorth, Sven ^f   Prada, Giovanna ^g   Luyben, Karel Ch A M ^c   Nienow, Alvin W ^b  

^a LONZA AG   (Switzerland)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^d Pharmacia & Upjohn AB   (Sweden)

^e Box 965   (Sweden)

^f SCABA Agitators   (Sweden)

^g Ingenieurschule Wallis   (Switzerland)

Author keywords

Foam; Gas foam entrainment; Mechanical foam control; Multiple impellers; Scale up

Indexed keywords

AGITATION; ARTICLE; BIOREACTOR; DISPERSION; ESCHERICHIA COLI; FERMENTATION; FOAM; FOAMING; IMPELLER; LIQUID; PUMP; VELOCITY; VOLUMETRY;

ESCHERICHIA COLI;

EID: 12244310198     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10295-003-0023-7     Document Type: Article

References (18)

1. Boon LA (2000) Mixing studies related to the scale-up of bioreactors. Ph.D Thesis, University of Birmingham, Birmingham, UK
2. Boon LA, Hoeks FWJMM, van der Lans RGJM, Bujalski W, Nienow AW (2000) Instabilities when using a standard (T/3) Rushton turbine for "Stirring as Foam Disruption" (SAFD). Can J Chem Eng 78:884-891
3. Boon LA, Hoeks FWJMM, van der Lans RGJM, Bujalski W, Wolff MO, Nienow AW (2002) Comparing a range of impellers for "stirring as foam disruption". Biochem Eng J 10:183-195
4. Bujalski W, Konno M, Nienow AW (1988) Scale-up of 45° pitch blade agitators for gas dispersion and solid suspension. In: Proceedings of the 6th European Conference on Mixing, May 24-26, 1988, Pavia, Italy
5. Hjorth S, Karlsson L, Friberg P, Boon L (2000) Electrical power measurements - a tool for process control. Can J Chem Eng 78:1127-1132
6. Hoeks FWJMM, van Wees-Tangerman C, Gasser K, Mommers HM, Schmid S, Luyben KChAM (1997) Stirring as foam disruption (SAFD) technique in fermentation processes Can J Chem Eng 75:1018-1029
7. Hudcova V, Machon V, Nienow AW (1988) Gas-liquid dispersion with dual Rushton turbine impellers. Biotechnol Bioeng 34:617-628
8. Joshi JB, Pandit AB, Sharma MM (1982) Mechanically agitated gas-liquid reactors. Chem Eng Sci 37:813-844
9. Kuboi R, Nienow AW, Allsford KV (1983) A multipurpose stirred tank facility for flow visualisation and dual impeller power measurement. Chem Eng Commun 22:29-39
10. Lee JC, Salih MA, Sebai NN, Withney A (1993) Control of foam in bioreactors - action of anti-foams. In: Nienow AW (ed) Proceedings of the 3rd International Conference on Bioreactor and Bioprocess Fluid Dynamics, Cambridge, UK, 14-16 September 1993. Mechanical Engineering Publishers, London, pp 275-287
11. Martin T, McFarlane CM, Nienow AW (1994) The influence of liquid properties and impeller type on bubble coalescence behaviour and mass transfer in sparged, agitated bioreactors. In: Proceedings of the 8th European Mixing Conference. Cambridge, UK, 14-16 September 1994. Institute of Chemical Engineers, Rugby, pp 57-64
12. Nienow AW (1999) The versatility of up-pumping, wide-blade hydrofoil agitators. In: Proceedings of the 3rd International Symposium on Mixing in Industrial Processes, ISMIP-3, Osaka, Japan, 19-22 September 1999. The Society of Chemical Engineers, Japan, pp 173-180
13. Otomo N, Nienow AW, Bujalski W (1993) Mixing time measurements for an aerated, single and dual-impeller stirred vessel by using conductivity technique. The 1993 Institute of Chemical Engineers Research Event, pp 669-671
14. Perry RH, Chilton CH (1973) Chemical engineers' handbook, 5th edn. McGraw-Hill, New York, pp 22-45
15. Schubert J, Wan L, Lübbert A (1993) Foam suppression by bioreactor retrofitting. In: Nienow AW (ed) Proceedings of the 3rd International Conference on Bioreactor and Bioprocess Fluid Dynamics, Cambridge, UK, 14-16 September 1993. Mechanical Engineering Publishers, London, pp 521-532
16. Smith JM, Warmoeskerken MCG, Zeef E (1987) Flow conditions in vessels dispersing gases in liquids with multiple impellers. In: Ho CS, Oldshue JY (eds) Biotechnology processes. Am Inst Chem Eng, New York, pp 107-115
17. Xu B, Jahic M, Blomsten G, Enfors SO (1999) Glucose overflow metabolism and mixed acid fermentation in aerobic large-scale fed-batch processes with Escherichia coli. Appl Microbiol Biotechnol 51:564-571
18. Yasukawa M, Onodera M, Yamagiwa K, Ohkawa A (1991) Gas holdup, power consumption, and oxygen absorption coefficient in a stirred-tank fermentor under foam control. Biotechnol Bioeng 38:629-636