Effect of L-carnitine on weight loss and body composition of rats fed a hypocaloric diet

Annals of Nutrition and Metabolism

Volumn 46, Issue 5, 2002, Pages 205-210

  Brandsch, Corinna ^b   Eder, Klaus ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b NONE

Author keywords

Body composition; Body weight reduction; Carnitine; Energy deficiency; Rat

Indexed keywords

3 HYDROXYBUTYRIC ACID; CARNITINE; CHOLESTEROL; FATTY ACID; GLUCOSE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY FAT; BODY WEIGHT; CHEMICAL PARAMETERS; CHOLESTEROL BLOOD LEVEL; CLINICAL CHEMISTRY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; ENERGY; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; INTESTINE; KIDNEY; LOW CALORY DIET; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TESTIS; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION;

ANIMALS; BLOOD GLUCOSE; BODY COMPOSITION; CALORIC RESTRICTION; CARNITINE; CHOLESTEROL; DIETARY SUPPLEMENTS; FATTY ACIDS; MALE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TRIGLYCERIDES; WEIGHT LOSS;

ANIMALIA;

EID: 12244309563     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000065408     Document Type: Article

References (29)

1. Friedman S, Fraenkel G: Reversible acetylation of carnitine. Arch Biochem Biophys 1955;51:491-501.
2. Bremer J: Biosynthesis of carnitine in vivo. Biochem Biophys Acta 1961;48:622-624.
3. Raymond TL, Reynolds SA, Swanson JA, Patnode CA, Bell FP: The effect of oral L-carnitine on lipoprotein composition in the Watanabe heritable hyperlipidemic rabbit (Oyctolagus cuniculus). Comp Biochem Physiol 1987;88A:503-506.
4. Mondola P, Belfiori A, Santangelo F, Santillo M: The effect ofL-carnitine on the apolipoprotein pattern of rats fed a cholesterol-enriched diet. Comp Biochem Physiol 1988;89B:69-73.
5. Seccombe DW, James L, Hahn P, Jones E: L-Carnitine treatment in the hyperlipidemic rabbit. Metab 1987;36:1192-1196.
6. Maccari F, Arseni A, Chiodi P, Ramacci MT, Agenlucci L, Hulsmann WC: L-Carnitine effect on plasma lipoproteins of hyperlipidemic fat-loaded rats. Lipids 1987;22:1005-1008.
7. Clouet P, Sempore G, Tsoko M, Gresti J, Demarquoy J, Niot I, Bezard J, Martin-Privat P: Effect of short- and long-term treatments by a low level of dietary L-carnitine on parameters related to fatty acid oxidation in Wistar rat. Biochim Biophys Acta 1996;1299:191-197.
8. Hongu N, Sachan DS: Caffeine, carnitine and choline supplementation of rats decrease body fat and serum leptin concentration as does exercise. J Nutr 2000;130:152-157.
9. Rabie MH, Szilagyi M, Gippert T, Votisky E, Gerendai D: Influence of dietary L-carnitine on performance and carcass quality of broiler chickens. Acta Biol Hung 1997;48:241-252.
10. Rabie MH, Szilagyi M. Effects of L-carnitine supplementation of diets differing in energy levels on performance, abdominal fat content, and yield and composition of edible meat of broilers. Br J Nutr 1998;80:391-400.
11. Musser RE, Goodband RD, Tokach MD, Owen KQ, Nelssen JL, Blum SA, Dritz SS, Civis CA: Effects of L-carnitine fed during gestation and lactation on sow and litter performance. J Anim Sci 1999;77:3289-3295.
12. McCarthy MF: The unique merits of a low-fat diet for weight control. Med Hypotheses 1986;20:183-197.
13. Center SA, Harte J, Watrous DD, Reynolds A, Watson TD, Markwell PJ, Millington DS, Wood PA, Yeager AE, Erb HN: The clinical and metabolic effects of rapid weight loss in obese pat cats and the influence of supplemental oral L-carnitine. J Vet Int Med 2000;14:598-608.
14. Gross KL, Wedekind KJ, Kirk CA, Jewell DE, Scheonherr WD, Blum SA, Owen KQ: Effect of dietary carnitine or chromium on weight loss and body composition of obese dogs. J Anim Sci 1998;76(suppl 1):175.
15. Center SA, Reynolds AP, Harte J, Watson T, Markwell PJ, Erb HN, Millington DS, Wood P, Yeager AE, Watrous D: Clinical effects of rapid weight loss in obese pat cats with and without supplemental L-carnitine. ACVIM Abstr 1997;118:58.
16. Center SA, Reynolds AP, Harte J, Watson T, Markwell PJ, Erb HN, Millington DS, Wood P, Yeager AE, Watrous D: Metabolic influence of oral L-carnitine during a rapid 18 week weight loss program in obese cats. ACVIM Abstr 1997;118:57.
17. Armstrong PJ, Hardie EM, Cullen JM, Keene BW, Hand MS, Babineau C: L-Carnitine reduces hepatic fat accumulation during rapid weight reduction in cats. ACVIM Abstr 1992;6:127.
18. NRC (National Research Council). Nutrient Requirements of Laboratory Animals, ed 4. Washington, National Academy Press, 1995.
19. Hara A, Radin NS: Lipid extraction of tissues with a low-toxicity solvent. Anal Biochem 1978;90:420-426.
20. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
21. Maeda J, Dudrick SJ: Rapid spectrophotometric determination of plasma carnitine concentrations. J Parent Ent Nutr 1990;14:527-532.
22. Clouet P, Sempore G, Tsoko M, Gresti J, Demarquoy J, Niot I, Bezard J, Martin-Privat P: Effect of short- and long-term treatments by a low level of dietary L-carnitine on parameters related to fatty acid oxidation in Wistar rat. Biochim Biophys Acta 1996;1299:191-197.
23. Meijer GW, Beynen AC: Influence of dietary carnitine on lipid and carbohydrate metabolism in rats. Z Ernährungsw 1988;27:77-83.
24. Blazquez C, Sanchez C, Valasco GG, Guzman M: Role of carnitine palmitoyltransferase I in the control of ketogenesis in primary cultures of rat astrocytes. J Neurochem 1998;71:1597-1606.
25. Najajima T, Horiguchi M, Yamanaka H, Kizaki Z, Inoue F, Kudo N, Kinugasa A, Saheki T, Sawada T: The effect of carnitine on ketogenesis in perfused livers from juvenile visceral steatosis mice with systemic carnitine deficiency. Pediatr Res 1997;42:108-113.
26. Michealakakis H: Carnitine supplementation and ketogenesis by small-for-date neonates on medium- and long-chain fatty acid formulae. Biol Neonate 2000;77:25-28.
27. Rhew TH, Sachan DS: Dose-dependent lipotropic effect of carnitine in chronic alcoholic rats. J Nutr 1986;116:2263-2269.
28. Harris RC, Foster CVL, Snow DH: Plasma carnitine content and uptake into muscle following oral and intravenous administration. Equine Vet J 1995;(suppl 18):382-387.
29. Eder K: L-Carnitine supplementation and the lipid metabolism of rats fed a hyperlipidemic diet. J Anim Physiol Anim Nutr 2000;83:132-140.