Using carcinogenic potency ranking to assign air contaminants to emission classes

Regulatory Toxicology and Pharmacology

Volumn 36, Issue 3, 2002, Pages 221-233

  Schuhmacher Wolz, Ulrike ^a   Konietzka, Rainer ^b   Schneider, Klaus ^a  

^a Res/Advsy Inst Haz Sub (FoBiG)   (Germany)

^b UMWELTBUNDESAMT   (Germany)

Author keywords

Air contaminants; Carcinogenic potency ranking; CELmin approach; ED10 LED10 method; T25 approach; Unit risk estimates; Unit risk quality criteria

Indexed keywords

1,2 DICHLOROETHANE; 1,3 BUTADIENE; 2 BUTANONE OXIME; 2 METHYLANILINE; ACRYLAMIDE; ACRYLONITRILE; ANTIMONY DERIVATIVE; ARSENIC; ASBESTOS FIBER; BENZENE; CADMIUM; CARCINOGEN; CHROMIUM; COBALT; CYCLOHEXENE DERIVATIVE; ETHYL BROMIDE; ETHYLENE OXIDE; MINERAL FIBER; NICKEL; PROPYLENE OXIDE; SILICON DIOXIDE; STYRENE OXIDE; TOLUENE DERIVATIVE; TRICHLOROETHYLENE; UNCLASSIFIED DRUG; VINYL CHLORIDE;

AIR POLLUTION; AIR QUALITY CONTROL; ARTICLE; CANCER LOCALIZATION; CANCER RISK; CHEMICAL CARCINOGENESIS; CONCENTRATION (PARAMETERS); DATA BASE; GEOMETRY; HUMAN; LAW; NONHUMAN; PRIORITY JOURNAL; PYROLYSIS; RISK ASSESSMENT; RISK FACTOR;

ANIMALIA;

EID: 12244284661     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.2002.1579     Document Type: Article

References (84)

1. Allen, B. C., Crump, K. S., and Shipp, A. M. (1988). Correlation between carcinogenic potency of chemicals in animals and humans. Risk Anal. 8, 531-544.
2. Barber, E., and Donish, W. (1982). An exposure system for qualitative measurements of microbial mutagenicity of volatile liquids. Environ. Sci. Res. 25, 3-18.
3. Besemer, A. C., van Esch, G. J., Hollander, J. C. T., Huldy, H. J., Laurier, M. B. H. M., and Maas, R. J. M. (1984). Criteriadocument Over 1,2-dichloorethaan. Rijksinstituut voor Volksgezondheid en Milieuhygiene, Bilthoven.
4. Brock, W. J., Hundley, S. G., and Lieder, P. H. (1990). Hepatic macromolecular binding and tissue distribution of ortho- and para-toluidine in rats. Toxicol. Lett. 54, 317-325.
5. Bucher, J. R., Morgan, D. L., Adkins, B., Jr., Travlos, G. S., Davis, B. J., Morris, R., and Elwell, M. R. (1995). Early changes in sex hormones are not evident in mice exposed to the uterine carcinogens chloroethane or bromoethane. Toxicol. Appl. Pharmacol. 130, 169-173.
6. Bukowski, J. A., Schnatter, A. R., and Korn, L. (2001). Using epidemiological studies to check the consistency of the cancer risks predicted by high-dose animal experiments: A methodological review. Risk Anal. 21, 601-612.
7. Calabrese, E. J., and Kenyon, E. M. (1991). Air Toxics and Risk Assessment. Lewis, Chelsea, MI.
8. California Environmental Protection Agency (CEPA) (1992). Proposed Identification of 1,3-Butadiene as a Toxic Air Contaminant. Part B: Health Assessment. Stationary Source Division.
9. Chhabra, R. S., Huff, J., Haseman, J., Jokinen, M. P., and Hetjmancik, M. (1990). Dermal toxicity and carcinogenicity of 4-vinyl-1-cyclohexene diepoxide in Fischer rats and B6C3F1 mice. Fundam. Appl. Toxicol. 14, 752-763.
10. Collins, J. F., and Marty, M. A. (1995). Cancer risk assessment for crystalline silica to implement California's hot spot act. Scand. J. Work Environ. Health 21, 99-103.
11. Collins, J. F., and Marty, M. A. (1997). Cancer risk assessment for crystalline silica. J. Expo. Anal. Environ. Epidemiol. 7, 359-365.
12. Conaway, C. C., Hussain, N. S., Way, B. M., and Fiala, E. S. (1991). Evaluation of secondary nitroalkanes, their nitronates, primary nitroalkanes, nitrocarbinols, and other aliphatic nitro compounds in the Ames Salmonella assay. Mutat. Res. 261, 197-207.
13. Conti, B., Maltoni, C., Perino, G., and Ciliberti, A. (1988). Long-term carcinogenicity bioassays on styrene administered by inhalation, ingestion and injection and styrene oxide administered by ingestion in Sprague-Dawley rats, and para-methylstyrene administered by ingestion in Sprague-Dawley rats and Swiss mice. Ann. NY Acad. Sci. 534, 203-234.
14. Crump, K., Allen, B., and Shipp, A. (1989). Choice of dose measure for extrapolating carcinogenic risk from animals to humans: An empirical investigation of 23 chemicals. Health Phys. 57, 387-394.
15. Danford, N. (1991). The genetic toxicology of ortho-toluidine. Mutat. Res. 258, 207-236.
16. Denk, B., and Filser, J.-G. (1990). Abschätzung des durch ethylen und ethylenoxid bedingten kanzerogenen risikos für den menschen-vergleich mit dem risiko durch endogenes ethylen. In Berufskrankheiten-Krebserzeugende Arbeitsstoffe-Biological-Monitoring. 30. Jahrestagung der Deutschen Gesellschaft für Arbeitsmedizin in Frankfurt/M.-Höchst vom 28. bis 31. Mai 1990 (F. Schuckmann and S. Schopper-Jochum, Eds.), pp. 397-401. Gentner-Verlag, Stuttgart.
17. Dybing, E., Sanner, T., Roelfzema, H., Kroese, D., and Tennant, R. W. (1997). T25: A simplified carcinogenic potency index: Description of the system and study of correlations between carcinogenic potency and species/site specificity and mutagenicity. Pharmacol. Toxicol. 80, 272-279.
18. Eikmann, T., Heinrich, U., Heinzow, B., and Konietzka, R. (2000). Gefährdungsabschätzung von Umweltschadstoffen. Ergänzbares Handbuch Toxikologischer Basisdaten und ihre Bewertung. Erich Schmidt-Verlag, Berlin.
19. Environmental Protection Agency (EPA) (1984). Carcinogen Assessment of Coke Oven Emissions. Final Report. USEPA, Washington, DC.
20. Environmental Protection Agency (EPA) (1985a). Health Assessment Document for Ethylene Oxide. May 1985. EPA-600/8-84-009F.
21. Environmental Protection Agency (EPA) (1985b). Health Assessment Document for 1,2-Dichloroethane (Ethylene Dichloride). Final Report. USEPA, Research Triangle Park, NC.
22. Environmental Protection Agency (EPA) (1998). Draft: Health Risk Assessment for 1,3-Butadiene. National Center for Environmental Assessment, Office of Research and Development, USEPA.
23. Environmental Protection Agency (EPA) (1999a). Guidelines for Carcinogen Risk Assessment. Draft. USEPA, Washington, DC.
24. Environmental Protection Agency (EPA) (1999b). Toxicological Review: Cadmium and Compounds. External Review Draft, in Support of Summary Information on Integrated Risk Information System (IRIS), March 4, 1999, Washington, DC.
25. Environmental Protection Agency (EPA) (1999c). IRIS, Integrated Risk Information System. CD-ROM Database, Silver Platter, NY, USA.
26. Environmental Protection Agency (EPA) (2000a). IRIS, Integrated Risk Information System. CD-ROM Database, Silver Platter, NY, USA.
27. Environmental Protection Agency (EPA) (2000b). Iris Summary for Vinyl Chloride. USEPA.
28. Fayerweather, W. E., Bender, J. R., Hadley, J. G., and Eastes, W. (1997). Quantitative risk assessment for a glass fiber insulation product. Regul. Toxicol. Pharmacol. 25, 103-120.
29. Felter, S. P., and Dollarhide, J. S. (1997). Acrylonitrile: A reevaluation of the data base to support an inhalation cancer risk assessment. Regul. Toxicol. Pharmacol. 26, 281-287.
30. Fiala, E. S., Sodum, R. S., Hussain, N. S., Rivenson, A., and Dolan, L. (1995). Secondary nitroalkanes: Induction of DNA repair in rat hepatocytes, activation by aryl sulfotransferase and hepatocarcinogenicity of 2-nitrobutane and 3-nitropentane in male F344 rats. Toxicology 99, 89-97.
31. Fisher, J. W., and Allen, B. C. (1993). Evaluating the risk of liver cancer in humans exposed to trichloroethylene using physiological models. Risk Anal. 13, 87-95.
32. Goldsmith, D. F. (1997). Evidence for silica's neoplastic risk among workers and derivation of cancer risk assessment. J. Expo. Anal. Environ. Epidemiol. 7, 291-301.
33. Goldsmith, D. F., Ruble, R. P., and Klein, C. O. (1995). Comparative cancer potency for silica from extrapolations of human and animal findings. Scand. J. Work Environ. Health 21, 104-107.
34. Goodman, G., and Wilson, R. (1991a). Quantitative prediction of human cancer risk from rodent carcinogenic potencies: A closer look at the epidemiological evidence for some chemicals not definitely carcinogenic in humans. Regul. Toxicol. Pharmacol. 14, 118-146.
35. Goodman, G., and Wilson, R. (1991b). Predicting the carcinogenicity of chemicals in humans from rodent bioassay data. Environ. Health Perspect. 94, 195-218.
36. Groth, D. H., Stettler, L. E., Burg, J. R., Busey, W. M., Grant, G. C., and Wong, L. (1986). Carcinogenic effects of antimony trioxide and antimony ore concentrate in rats. J. Toxicol. Environ. Health 18, 607-626.
37. Hassauer, M., Kalberlah, F., and Griem, P. (1999). Trichlorethen. In Gefährdungsabschätzung von Umweltschadstoffen. Ergänzbares Handbuch Toxikologischer Basisdaten und ihre Bewertung (T. Eikmann, U. Heinrich, B. Heinzow, and R. Konietzka, Eds.), Kennziffer D 932. Erich Schmidt-Verlag, Berlin.
38. Henschler, D. (1986/1987). Gesundheitsschädliche Arbeitsstoffe, Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten. VCH, Weinheim.
39. Henschler, D. (1992). Gesundheitsschädliche Arbeitsstoffe, Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten. VCH, Weinheim.
40. Hesse, J. M., and Kroese, E. D. (1994). Benzeen: Herevaluatie Advieswaarde. Rep. 601014002. RIVM, Bilthoven.
41. Hussain, N. S., Nie, G., Conaway, C. C., Sohn, O. S., and Fiala, E. S. (1991). Oxidative damage to liver DNA and RNA of rats treated with ketoximes. Proc. AACR 32, 149.
42. International Agency for Research on Cancer (IARC) (2000). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol. 77. Some Industrial Chemicals. World Health Organization, Geneva.
43. Johnson, K. A., Gorzinski, S. J., Bodner, K. M., Campbell, R. A., Wolf, C. H., Friedman, M. A., and Mast, R. W. (1986). Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol. Appl. Pharmacol. 85, 154-168.
44. Johnston, P. K., and Rock, A. R. (1990). A risk assessment for acrylonitrile in consumer products. Sci. Total Environ. 99, 263-279.
45. Kalberlah, F., and Schneider, K. (1998). Quantifizierung von Extrapolationsfaktoren. Endbericht des Forschungsvorhabens Nr. 116 06 113 des Umweltbundesamtes. Schriftenreihe der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin, Fb 796. Wirtschaftsverlag NW, Bremerhaven.
46. Kalberlah, F., Hassauer, M., Konietzka, R., and Schneider, K. (1995). Qualitätsbeurteilung von unit-risk-Berechnungen. In Epidemiologische Methoden der Risikoabschätzung für Krebserzeugende Umweltstoffe mit Anwendungsbeispielen (H. Becher, K. Steindort, and J. Wahrendorf, Eds.), pp. 302-320. Erich Schmidt-Verlag, Berlin.
47. Kalberlah, F., Hassauer, M., Frijus-Plessen, N., and Schneider, K. (1997). Toxicological risk assessment of soil contaminants. Int. J. Toxicol. 16, 495-508.
48. Kalberlah, F., Hassauer, M., Schneider, K., and Konietzka, R. (1999). Methodische beschreibung des F + E-vorhabens basisdaten toxikologie für umweltrelevante stoffe zur gefahrenbeurteilung bei altlasten. In Gefährdungsabschätzung von Umweltschadstoffen. Ergänzbares Handbuch Toxikologischer Basisdaten und Ihre Bewertung (T. Elkmann, U. Heinrich, B. Heinzow, and R. Konietzka, Eds.), Kennziffer B010. Erich Schmidt-Verlag, Berlin.
49. Konietzka, R. (1999). Handlungsorientierte vorgehensweise zur berücksichtigung kanzerogener wWirkungen bei substanzen mit für die risikobetrachtung nicht geeigneter risikoquantifizierung, Anhang 3. In Gefährdungsabschätzung von Umweltschadstoffen. Ergänzbares Handbuch toxikologischer Basisdaten und ihre Bewertung (T. Eikmann, U. Heinrich, B. Heinzow, and R. Konietzka, Eds.), Anhang zu Kennziffer B010. Erich Schmidt-Verlag, Berlin.
50. Länderausschuss für Immissionsschutz (LAI) (1992). Krebsrisiko Durch Luftverunreinigungen. Ministerium für Umwelt, Raumordnung und Landwirtschaft des Landes Nordrhein-Westfalen.
51. Lijinsky, W. (1986). Rat and mouse forestomach tumors induced by chronic oral administration of styrene oxide. J. Natl. Cancer Inst. 77, 471-476.
52. Loveday, K. S., Lugo, M. H., Resnick, M. A., Anderson, B. E., and Zeiger, E. (1989). Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. II. Results with 20 chemicals. Environ. Mol. Mutagen. 13, 60-94.
53. Maltoni, C., Failla, G., and Kassapidis, G. (1979). First experimental demonstration of the carcinogenic effects of styrene oxide. Med. Lav. 5, 358-362.
54. Meijers, J. M., Swaen, G. M., and Bloemen, L. J. (1997). The predictive value of animal data in human cancer risk assessment. Regul. Toxicol. Pharmacol. 25, 94-102.
55. Moolgavkar, S. H., Luebeck, E. G., Turim, J., and Hanna, L. (1999). Quantitative assessment of the risk of lung cancer associated with occupational exposure to refractory ceramic fibers. Risk Anal. 19, 599-611.
56. Nagano, K., Nishizawa, T., Yamamoto, S., and Matsushima, T. (1998). Inhalation carcinogenesis studies of six halogenated hydrocarbons in rats and mice. In Advances in the Prevention of Occupational Respiratory Diseases (K. Chiyotani, Y. Hosoda, and Y. Aizawa, Eds.), pp. 741-746. Elsevier, Amsterdam.
57. National Cancer Institute (NCI) (1979). Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity. NCI Carcinogene-sis Technical Rep. Series No. 153, DHEW Publ. No. 79-1709, Washington, DC.
58. Neumann, H.-G., Thielmann, H. W., Filser, J. G., Gelbke, H.-P., Greim, H., Kappus, H., Norpoth, K. H., Reuter, U., Vamvakas, S., Wardenbach, P., and Wichmann, H.-E. (1997). Proposed changes in the classification of carcinogenic chemicals in the work area. Regul. Toxicol. Pharmacol. 26, 288-295.
59. National Toxicology Program (NTP) (1989a). Toxicology and Carcinogenesis Studies of Bromoethane (Ethyl Bromide) in F344/N Rats and B6C3F Mice (Inhalation Studies). U.S. Department of Health and Human Services, Public Health Service.
60. National Toxicology Program (NTP) (1989b). Toxicology and Carcinogenesis Studies of 4-Vinyl-1-cyclohexene Diepoxide in F344/N Rats and B6C3F Mice (Dermal Studies). U.S. Department of Health and Human Services; Public Health Service.
61. Oak Ridge National Laboratory (ORNL) (1987). Water Quality Criteria for 2,4-Dinitrotoluene and 2,6-Dinitrotoluene, Final Report. ORNL, Oak Ridge, TN.
62. Occupational Safety and Health Administration (OSHA) (1983). Preliminary Quantitative Risk Assessment for Ethylene Oxide. Office of Carcinogen Standards, Washington, DC.
63. Page, N. P., and Cook, B. (1990). Assessment of risk from exposure to acrylonitrile: The general approach used by a consultant. Sci. Total Environ. 99, 307-317.
64. Pott, F. (1994a). In Krebsgefahrdung Durch Künstliche Mineralfasern (M. Fischer, Ed.). bga Schriften 4/94. Institut für Wasser-, Boden- und Lufthygiene. MMV Medizin Verlag, Munich.
65. Pott, F. (1994b). Inhalierbare Fasern und ihre krebserzeugende Wirkung. In Krebserkrankungen durch Dioxine/Furane, Styrol und Mineralfasern. (Bundesanstalt für Arbeitsmedizin, Ed.). Tagungsbericht 1. Wirtschaftsverlag NW, Bremerhaven.
66. Rijksinstituut voor Volksgezondheid en Milieuhygiene (RIVM) (1984). Criteria document over acrylonitril. Ministerie van Volkshuisvesting, Ruimtelijke Ordening en Milieubeheer, Leidschendam.
67. Rinehart, W. E. (1993). An Inhalation Oncogenicity Study of Methylethylketoxime in Rats and Mice. Part I: Mice. Final Report. Study No. 89-8243M. (Abbreviated Copy - Individual Animal Data Removed), Industrial Health Foundation, Pittsburgh, PA.
68. Rinehart, W. E. (1994). An Inhalation Oncogenicity Study of Methylethylketoxime in Rats and Mice. Part II: Rats. Final Report. Study No. 89-8243R (Abbreviated Copy - Individual Animal Data Removed). Industrial Health Foundation, Inc., Pittsburgh, PA.
69. Roller, M. (1998). Ableitung Eines Unit Risk für Nickel Aufgrund der Studie von Andersen et al. (1996). Manuskript für den Beraterkreis Toxikologie des Ausschusses für Gefahrstoffe.
70. Roller, M., and Nies, E. (1999). Zur Risikoabschätzung von Cobalt(verbindungen). Vortrag in der 18. Sitzung des Unterausschusses V "Luftgrenzwerte" des Ausschusses für Gefahrstoffe (AGS), St. Augustin, 8. 9. 1999, cited from Schneider et al. (2001b).
71. Sanner, T., Dybing, E., Kroese, D., Roelfzema, H., and Hardeng, S. (1997). Potency grading in carcinogen classification. Mol. Carcinogen. 20, 280-287.
72. Sanner, T., Dybing, E., Willems, M. I., and Kroese, E. D. (2001). A simple method for quantitative risk assessment on non-threshold carcinogens based on the dose descriptor T25. Pharmacol. Toxicol. 88, 331-341.
73. Schneider, K., and Kalberlah, F. (2000). Antimon und Verbindungen. In Gefährdungsabschätzung von Umweltschadstoffen. Ergänzbares Handbuch Toxikologischer Basisdaten und Ihre Bewertung (T. Eikmann, U. Heinrich, B. Heinzow, and R. Konietzka, Eds.), Kennziffer D 092. Erich Schmidt-Verlag, Berlin.
74. Schneider, K., Konietzka, R., and Schuhmacher-Wolz, U. (2001). Klassierung krebserzeugender Luftschadstoffe für die novelliert TA Luft. Gefahrstoffe-Reinhalt. Luft. 61, 454-458.
75. Schneider, K., Schuhmacher-Wolz, U., Oltmanns, J., and Hassauer, M. (2002). Klassierung krebserzeugender Stoffe zur Begrenzung der Massenkonzentration im Abgas nach der Nr. 5.2.7.1.1 der TA Luft-Novelle (Entwurf). Bericht zum F + E Vorhaben 299 61 215 im Rahmen des Umweltforschungsplan des Bundesministers für Umwelt, Naturschutz und Reaktorsicherheit, Umweltbundesamt. Berichte 3/02, Erich Schmidt-Verlag, Berlin.
76. Schneiderman, M. S., Nisbet, I. C. T., and Brett, S. M. (1981). Assessment of risks posed by low levels of asbestos in the general environment. In Gesundheitliche Risiken von Asbest. Eine Stellungnahme des Bundesgesundheitsamtes (K. Aurand and W.-S. Kierski, Eds.), BGA-Bericht 4/81. Bundesgesundheitsamt, Berlin.
77. Umweltbundesamt (UBA) (1996). Aktualisierung des Forschungsberichtes 42: Basisdaten Toxikologie für Umweltrelevante Stoffe zur Gefahrenbeurteilung bei Altlasten mit Ableitung von Toxikologisch begründeten Tolerierbaren Resorbierten Körperdosen (TRD-Werten) für 1,2-Dichlorethan. Bericht zum F + E-Vorhaben 103 40 815 überarbeitung, Aktualisierung und Abstimmung der "Basisdaten Toxikologie" zum Bundesbodenschutzgesetz, erstellt von FoBiG im Auftrag des Umweltbundesamtes. Freiburg/Berlin, 1996.
78. Volkel, W., Wolf, N., Derelanko, M., and Dekant, W. (1999). Slow oxidation of acetoxime and methylethyl ketoxime to the corresponding nitronates and hydroxy nitronates by liver microsomes from rats, mice, and humans. Toxicol. Sci. 47, 144-150.
79. Wahrendorf, J., and Becher, H. (1990). Quantitative Risikoabschätzung für ausgewählte Umweltkanzerogene. Forschungsbericht 10606067, UBA-Berichte 1/1990, Berlin.
80. Wilson, R., Langer, A. M., and Nolan, R. P. (1999). A risk assessment for exposure to glass wool. Regul. Toxicol. Pharmacol. 30, 96-109.
81. Wiltse, J., and Dellarco, V. L. (1996). U.S. Environmental Protection Agency guidelines for carcinogen risk assessment: Past and future. Mutat. Res. 365, 3-16.
82. World Health Organization (WHO) (1987). Air Quality Guidelines for Europe. WHO Regional Publications European Series, No. 23. WHO, Copenhagen.
83. World Health Organization (WHO) (1999a). Air Quality Management. Air Quality Guidelines. WHO, Geneva (http://www.who.int/peh/ air/airguides2.htm).
84. World Health Organization (WHO) (1999b). Updated and Revision of WHO Air Quality Guidelines for Europe (http://www.who.dk/ envhlth/airqual.htm).