Effects of antisense oligo DNA on the antimicrobial activity of reactive oxygen intermediates and antimycobacterial agents against Mycobacterium avium complex

Kekkaku

Volumn 78, Issue 1, 2003, Pages 33-35

  Shimizu, Toshiaki ^b   Sato, Katsumasa ^b   Sano, Chiaki ^b   Sano, Keisuke ^b   Tomioka, Haruaki ^a  

^a SHIMANE UNIVERSITY   (Japan)

^b NONE

Author keywords

Antisense oligo DNA, H2O2 halogenation system; Clarithromycin; Mycobacterium avium complex; Rifampicin

Indexed keywords

ANTIINFECTIVE AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; CLARITHROMYCIN; COMPLEMENTARY DNA; ETHAMBUTOL; HYDROGEN PEROXIDE; POLYMYXIN B; RIFAMPICIN;

AHPC GENE; ANTIMICROBIAL ACTIVITY; ARTICLE; COMBINATION CHEMOTHERAPY; DNA BINDING; DRUG ACTIVITY; GENETIC SUSCEPTIBILITY; HALOGENATION; MACROPHAGE ACTIVATION; MYCOBACTERIUM INTRACELLULARE AVIUM; NONHUMAN; OXIDATIVE STRESS; OXYR GENE; STATISTICAL SIGNIFICANCE; SYSTEMIC DISEASE;

CLARITHROMYCIN; DNA-BINDING PROTEINS; DRUG RESISTANCE, BACTERIAL; HALOGENS; HYDROGEN PEROXIDE; MYCOBACTERIUM AVIUM COMPLEX; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; REPRESSOR PROTEINS; RIFAMPIN; TRANSCRIPTION FACTORS; VIRULENCE;

EID: 12244282090     PISSN: 00229776     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Tomioka H: Prospects for development of new antimycobacterial drugs. J Infect Chemother. 2000; 6: 8-20.
2. Cole ST, Brosch R, Parkhill J, et al.: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998; 393: 537-544.
3. Glickman MS, Jacobs WR: Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline. Cell. 2001; 104: 477-485.
4. Harth G, Zamecnik PC, Tang JY, et al.: Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly-L-glutamate/glutamine cell wall structure, and bacterial replication. Proc Natl Acad Sci USA. 2000; 97: 418-423.
5. Hingley-Wilson SM, Sly LM, Reiner NE, et al.: The immunology of the mycobacterial infected macrophage. Mod Asp Immunobiol. 2000; 1: 96-101.
6. Sherman DR, Sabo PJ, Hickey MJ, et al.: Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria. Proc Natl Acad Sci USA. 1995; 92: 6625-6629.
7. Wilson T, de Lisle GW, Marcinkeviciene JA, et al.: Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties. Microbiology. 1998; 144: 2687-2695.
8. Bryk R, Lima CD, Erdjument-Bromage H, et al.: Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science. 2002; 295: 1073-1077.