Cobalamin-binding proteins in normal and cobalamin-deficient older subjects

Annals of Clinical Biochemistry

Volumn 40, Issue 1, 2003, Pages 65-69

  Van Asselt, Dieneke Z B ^a,b   Thomas, Chris M G ^a   Segers, Martin F G ^a   Blom, Henk J ^a   Wevers, Ron A ^a   Hoefnagels, Willibrord H L ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MCL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COBALAMIN BINDING PROTEIN; CYANOCOBALAMIN; HAPTOCORRIN; TRANSCOBALAMIN; UNCLASSIFIED DRUG; VITAMIN BINDING PROTEIN;

ADULT; AGE; AGED; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DIAGNOSTIC VALUE; DISEASE MARKER; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN FUNCTION; SENESCENCE; VOLUNTEER;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CHEMISTRY, CLINICAL; FEMALE; HUMANS; MALE; MIDDLE AGED; TRANSCOBALAMINS; VITAMIN B 12;

EID: 12244267966     PISSN: 00045632     EISSN: None     Source Type: Journal    
DOI: 10.1258/000456303321016187     Document Type: Article

References (16)

1. England JM, Down MC, Wise IJ, Linell JC. The transport of endogenous vitamin B12 in normal human serum. Clin Sci Mol Med 1976; 51: 47-52
2. van Asselt DZ, de Groot LC, van Staveren WA, Blom HJ, Wevers RA, Biemond I, et al. Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects. Am J Clin Nutr 1998; 68: 328-34
3. Carmel R. Subtle and atypical cobalamin deficiency states. Am J Hematol 1990; 34: 107-14
4. Van Asselt DZ, Van Den Broek WJ, Lamers CB, Corstens FH, Hoefnagels WH. Free and protein-bound cobalamin absorption in healthy middle-aged and elderly subjects. J Am Geriatr Soc 1996; 44: 949-53
5. Nexø E. Variation with age of reference values for P-cobalamins. Scand J Haematol 1983; 30: 430-2
6. Marcus DL, Shadick N, Crantz J, Gray M, Hernandez F, Freedman ML. Low serum B12 levels in a hematologically normal elderly population. J Am Geriatr Soc 1987; 35: 635-8
7. 12 concentration in older people: A case control study. J Am Geriatr Soc 1996; 44: 1355-61
8. 12 balance. Lab Invest 1988; 58: 332-7
9. Van Asselt DZ, Pasman JW, Van Lier HJ, Vingerhoets DM, Poels PJP, Kuin Y, et al. Cobalamin supplementation improves cognitive and cerebral function in older cobalamin deficient persons. J Gerontol: Med Sci 2001; 56A: M775-9
10. Van Asselt DZ, Blom HJ, Zuiderent R, Wevers RA, Jakobs C, van den Broek WJ, et al. Clinical significance of low cobalamin levels in older hospital patients. Neth J Med 2000; 57: 41-9
11. Benhayoun S, Adjalla C, Nicolas JP, Guéant JL, Lambert D. Method for the direct specific measurement of vitamin B12 bound to transcobalamin II in plasma. Acta Haematol 1993; 89: 195-9
12. Nielsen C, Odgaard G. FK 383 DS, a new silica gel for the determination of unsaturated haptocorrin and transcobalamin II in serum. Scand J Clin Lab Invest 1992; 52: 767-9
13. Rasmussen K. Solid-phase sample extraction for rapid determination of methylmalonic acid in serum and urine by a stable-isotope-dilution method. Clin Chem 1989; 35: 260-4
14. Te Poele-Pothoff MT, van den Berg M, Franken DG, Boers GH, Jakobs C, de Kroon IF, et al. Three different methods for the determination of total homocysteine in plasma. Ann Clin Biochem 1995; 32: 218-20
15. Vu T, Amin J, Ramos M, Flener V, Vanyo L, Tisman G. New assay for the rapid determination of plasma holotranscobalamin II levels: Preliminary evaluation in cancer patients. Am J Hematol 1993; 42: 202-11
16. Lindenbaum J, Rosenberg IH, Wilson PWF, Stabler S, Allen RH. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994; 60: 2-11