Rational use of antibiotics in the intensive care unit: Impact on microbial resistance and costs

Intensive Care Medicine

Volumn 29, Issue 1, 2003, Pages 49-54

  Geissler, Alain ^a   Gerbeaux, Patrick ^b   Granier, Isabelle ^a   Blanc, Philippe ^a   Facon, Karine ^a   Durand Gasselin, Jacques ^a  

^a Hopital Font Pre   (France)

^b APHM and UMR S1076   (France)

Author keywords

Antibiotic resistance; Antimicrobial use density; Cost; Evaluation; Nosocomial infections; Policy

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CARBAPENEM; CEFTRIAXONE; CEPHALOSPORIN; GLYCOPEPTIDE; METICILLIN; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL MUTATION; CEFTRIAXONE RESISTANT ENTEROBACTERIACEAE; CONTROLLED STUDY; COST BENEFIT ANALYSIS; DRUG COST; DRUG USE; ENTEROBACTERIACEAE; EVALUATION; HEALTH CARE COST; HEALTH CARE POLICY; HOSPITAL INFECTION; HUMAN; INCIDENCE; INTENSIVE CARE; MAJOR CLINICAL STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NATURAL SELECTION; POPULATION DENSITY; PSEUDOMONAS AERUGINOSA; STATISTICAL ANALYSIS;

EID: 12244260750     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-002-1565-2     Document Type: Article

References (30)

1. Fagon JY, Chastre J, Hance AJ, Montravers P, Novara A, Gibert C (1993) Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay. Am J Med 94:281-288
2. Pittet D, Tarara D, Wenzel RP (1994) Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs and attributable mortality. JAMA 271:1598-1601
3. Bueno-Cavanillas A, Delgado-Rodriguez M, Lopez-Luque A, Schaffino-Cano S, Calvez-Vargas R (1994) Influence of nosocomial infection on mortality rate in a intensive care unit. Crit Care Med 22:55-60
4. Vincent JL, Bihari DJ, Suter PM, Bruining HA, White J, Nicolas-Chanoine MH, Wolff M, Spencer RC, Hemmer M (1995) The prevalence of nosocomial infection in intensive care units in Europe. Results of the European prevalence of infection in intensive care (EPIC study). JAMA 274:639-644
5. Fomsgaard A, Hoiby N, Friis H, Gahrn-Hansen B, Kolmos HJ, Schouenborg P, Korsager B, Tvede M, Gutschik E, Bremmelgaard A (1995) Prevalence and antibiotic sensitivity of Danish versus other European bacterial isolates from intensive and hematology/oncology units. Eur J Clin Microb Infect Dis 14:275-281
6. McGowan JE (1983) Antimicrobial resistance in hospital organisms and its relation to antibiotic use. Rev Infect Dis 5:1033-1048
7. Weinstein RA, Nathan C, Gruensfelder R, Kabins SA (1980) Endemic aminoglycosides resistance in gram-negative bacilli: epidemiology and mechanism. J Infect Dis 141:338-345
8. Archibald L, Phillips L, Monnet D, Mc-Gowan JE, Tenover F, Gaynes R (1997) Antimicrobial resistance in isolates from inpatients and outpatients in the United States: increasing importance of intensive care unit. Clin Infect Dis 24:211-215
9. Monnet DL, Archibald L, Phillips L, Tenover F, McGowan JE, Gaynes RP (1998) Antimicrobial use and resistance in eight US hospitals: complexities of analysis and modeling. Intensive Care Antimicrobial Resistance Epidemiology (ICARE) Project and National Nosocomial Infections Surveillance System Hospital. Infect Control Hosp Epidemiol 19:388-394
10. Le Gall JR, Lemeshow S, Saulnier F (1993) A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA 270:2957-2963
11. Sznajder M, Leleu G, Buonamico G, Auvert B, Aegerter P, Merliere Y, Dutheil M, Guidet B, Le Gall JR (1998) Estimation of direct cost and resource allocation in intensive care: correlation with Omega score. Intensive Care Med 24:582-589
12. Brun-Buisson C, Abrouk F, Legrand P, Huet Y, Lanabi S, Rapin M (1987) Diagnosis of central venous catheter-related sepsis. Critical level of quantitative tip cultures. Arch Intern Med 147:873-877
13. Quintiliani R, Nightingale CH, Cnowe HR, Cooper BW, Bantlett RC, Goisse G (1991) Strategic antibiotic decision-making at the formulary level. Rev Infect Dis 13:770-777
14. Aubert G, Levy PP, Ros A, Meley R, Bourge A, Dorche G (1992) Changes in the sensitivity of urinary pathogens to quinolons between 1987 and 1990 in France. Eur J Clin Microbiol Infect Dis 11:475-477
15. Infections liées aux cathéters veineux centraux en réanimation. XIIème conférence de consensus en réanimation et médecine d'urgence (1994) Réanim Urg 3:321-407
16. Blanc P, Von Elm BE, Geissler A, Granier I, Boussuges A, Durand-Gasselin J (1999) Economic impact of a rational use of antibiotics in intensive care. Intensive Care Med 25:1407-1412
17. White AC Jr, Atmar RL, Wilson J, Cate TR, Stager CE, Greenberg SB (1997) Effect of requiring prior authorization for selected antimicrobial: expenditures, susceptibilities and clinical outcomes. Clin Infect Dis 25:230-239
18. Toltzis P, Yamashita T, Vilt L, Green M, Morrisey A, Spinner-Block S, Blumer J (1998) Antibiotic restriction does not alter endemic colonization with resistant Gram-negative rods in a pediatric care unit. Crit Care Med 26:1893-1899
19. Jarlier V, Fosse T, Philippon A, the ICU Study Group (1996) Antibiotic susceptibility in aerobic Gram-negative bacilli isolated in intensive care units in 39 French teaching hospitals. Intensive Care Med 22:1057-1065
20. Halls GA (1993) Antimicrobial practice - the management of infections and antibiotic therapy: a European survey. J Antimicrob Chemother 31:985-1000
21. Spencer RC (1996) Predominant pathogens found in the European prevalence of infection in the intensive care study. Eur J Clin Microbiol Infect Dis 15:281-205
22. Ballow CH, Schentag JJ (1992) Trends in antibiotic utilization and bacterial resistance: report of the National Nosocomial Resistance Group. Diagn Microbiol Infect Dis 15:37S-42S
23. Boisivon A, Guiomar C, Gutmann L (1988) Interaction between piperacillin and pefloxacin or amikacin on the selection of resistant mutants of Pseudomonas aeruginosa. J Antimicrob Chemother 22:651-657
24. Chow JW, Fine MJ, Shlaes DM, Quinn JP, Hooper DC, Johnson MP, Ramphal P, Wagener MM, Miyashiro DK, Yu VL (1991) Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy. Ann intern Med 115:585-590
25. Jacobson KL, Cohen SH, Inciardi JF, King JH, Lippert WE, Iglesias T, VanCouwenberghe CJ (1995) The relationship between antecedent antibiotic use and resistance to extended-spectrum cephalosporins in group I β-lactamase-producing organisms. Clin Infect Dis 21:1107-1113
26. Livermore DM (1987) Clinical significance of β-lactamase induction and stable derepression in gram-negative rods. Eur J Clin Microbiol 6:439-445
27. Toltzis P, Yamashita T, Vilt L, Blumen JL (1997) Colonization with antibiotic resistant Gram-negative organisms in a pediatric intensive care unit. Crit Care Med 25:538-544
28. Winston DJ, Barnes RC, Ho WG, Young LS, Champlin RE, Gale RP (1984) Moxalactam plus piperacillin versus moxalactam plus amikacin in febrile granulocytopenic patients. Am J Med 77:442-450
29. McGowan JE (1994) Do intensive hospital antibiotic control programs prevent the spread of antibiotic resistance? Infect Control Hosp Epidemiol 15:478-483
30. Goldmann DA, Weinstein RA, Wenzel RP, Tablan OC, Duma RJ, Gaynes RP, Schlosser J, Martone WJ (1996) Strategies to prevent and control the emergence and spread of antimicrobial-resistant microorganisms in hospitals. JAMA 275:234-240