Sensitivity of renal cell carcinoma to aminoflavone: Role of CYP1A1

Journal of Urology

Volumn 171, Issue 4, 2004, Pages 1688-1697

  Loaiza Perez A I ^a   Kenney, S ^b   Boswell, J ^c   Hollingshead, M ^b   Hose, C ^c   Linehan, W M ^a   Worrell, R ^a   Rubinstein, L ^a   Sausville, E A ^a   Vistica, D T ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

Author keywords

Apoptosis; Carcinoma, renal cell; Cytochrome P 450 CYP1A1; Gene expression; Kidney

Indexed keywords

AMINOFLAVONE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DRUG METABOLITE; FLAVONE DERIVATIVE; MESSENGER RNA; SULFORHODAMINE B; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CLEAR CELL CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; DRUG EXPOSURE; DRUG METABOLISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; TUMOR XENOGRAFT;

EID: 12144291268     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000108860.03389.1b     Document Type: Article

References (15)

1. Manthey, J. A., Buslig, B. S. and Baker, M. E.: Flavonoids and cell function. In: Advances in Experimental Medicine and Biology 505. Edited by B. S. Buslig and J. A. Manthey. New York: Kluwer Academic/Plenum Publishers, pp. 1-7, 2002
2. Knekt, P., Jarvinen, R., Seppanen, R., Heliovaara, M., Teppo, L., Pukkala, E. et al: Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol, 146: 23, 1997
3. Le Marchand, L., Murphy, S. P., Hankin, J. H., Wilkens, L. R. and Kolonel, L. N.: Intake of flavonoids and lung cancer. J Natl Cancer Inst, 92: 154, 2000
4. Akama, T., Shida, Y., Sugaya, T., Ishida, H., Gomi, K. and Kasai, M.: Novel 5-aminoflavone derivatives as specific antitumor agents in breast cancer. J Med Chem, 39: 3461, 1996
5. Kuffel, M. J., Schroeder, J. C., Pobst, L. J., Naylor, S., Reid, J. M., Kaufman, S. H. et al: Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2. Mol Pharmacol, 62: 143, 2002
6. Loaiza-Perez, A. I., Kenney, S., Hollingshead, M., Alley, M. C., Hose, C., Ciolino, H. P. et al: Aryl hydrocarbon receptor activation of an antitumor aminoflavone: basis of selective toxicity for MCF-7 breast tumor cells. Unpublished data
7. Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D. et al: New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst, 82: 1107, 1990
8. Plowman, J., Dykes, D. J., Hollingshead, M., Simpson-Herren, L. and Alley, M. C.: Human tumor xenograft models in NCI drug development. In: Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval. Edited by B. Teicher. Totowa, New Jersey: Humana Press Inc., pp. 101-125, 1997
9. Geran, R. I., Greenberg, N. H., Macdonald, M. M., Schumacher, A. M. and Abbott, B. J.: Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemother Rep, 3: 51, 1972
10. Bradford, M. M.: A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principles of protein-dye binding. Anal Biochem, 72: 248, 1976
11. Snedecor, G. W. and Cochran, W. G.: Statistical Methods, 7th ed. Ames, Iowa: The Iowa State University Press, 1982
12. Chen, L. and Waxman, D. J.: Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer. Curr Pharm Des, 8: 1405, 2002
13. Yu, L. J., Matias, J., Scudiero, D. A., Hite, K. M., Monks, A., Sausville, E. A. et al: P450 enzyme expression patterns in the NCI human tumor cell line panel. Drug Metab Dispos, 29: 304, 2001
14. Rowlands, J. C. and Gustafsson, J. A.: Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol, 27: 109, 1997
15. Lu, Y. F., Santostefano, M., Cunningham, B. D., Threadgill, M. D. and Safe, S.: Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists. Biochem Pharmacol, 51: 1077, 1996