Bromodichloromethane inhibits human placental trophoblast differentiation

Toxicological Sciences

Volumn 78, Issue 1, 2004, Pages 166-174

  Chen, Jiangang ^a   Thirkill, Twanda L ^a   Lohstroh, Peter N ^a   Bielmeier, Susan R ^b   Narotsky, Michael G ^c   Best, Deborah S ^c   Harrison, Randy A ^c   Natarajan, Kala ^a   Pegram, Rex A ^c   Overstreet, James W ^a   Lasley, Bill L ^a   Douglas, Gordon C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Bioactivity; Desmosomes; Pregnancy; Toxicity

Indexed keywords

BROMODICHLOROMETHANE; CHORIONIC GONADOTROPIN;

ABORTION; CELL CULTURE; CELL DIFFERENTIATION; CELL DISRUPTION; CELL LEVEL; CELL NUCLEUS; CELL SECRETION; CELL STRUCTURE; CELL VIABILITY; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTROPHOBLAST; DESMOSOME; DISEASE ASSOCIATION; EXPOSURE; HORMONE ACTION; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; MONONUCLEAR CELL; MULTINUCLEAR CELL; PLACENTA DEVELOPMENT; PREGNANCY COMPLICATION; QUANTITATIVE ANALYSIS; REVIEW; STAINING; STATISTICAL SIGNIFICANCE;

ADULT; CELL DIFFERENTIATION; CELL FUSION; CELL NUCLEUS; CELL SURVIVAL; CHORIONIC GONADOTROPIN; DESMOSOMES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GIANT CELLS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOASSAY; INTERCELLULAR JUNCTIONS; L-LACTATE DEHYDROGENASE; PLACENTA; PREGNANCY; TRIHALOMETHANES; TROPHOBLASTS; WATER POLLUTANTS, CHEMICAL;

EID: 12144291016     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh046     Document Type: Review

References (60)

1. Aida, Y., Takada, K., Uchida, O., Yasuhara, K., Kurokawa, Y., and Tobe, M. (1992). Toxicities of microencapsulated tribromomethane, dibromochloromethane and bromodichloromethane administered in the diet to Wistar rats for one month. J. Toxicol. Sci. 17, 119-133.
2. Aronow, B. J., Richardson, B. D., and Handwerger, S. (2001). Microarray analysis of trophoblast differentiation: Gene expression reprogramming in key gene function categories. Physiol. Genomics 6, 105-116.
3. Bennett, J. P. (1982). Solubilization of membrane-bound enzymes and analysis of membrane protein concentration. In Techniques in Lipid and Membrane Biochemistry (T. R. Hesketh, H. L. Kornberg, J. C. Metcalfe, D. H. Northcote, C. I. Pogson, and K. F. Tipton, Eds.), pp. 1-22. Elsevier, Amsterdam.
4. Bielmeier, S. R., Best, D. S., Guidici, D. L., and Narotsky, M. G. (2001). Pregnancy loss in the rat caused by bromodichloromethane. Toxicol. Sci. 59, 309-315.
5. Bielmeier, S. R., Best, D. S., and Narotsky, M. G. (2004). Serum hormone characterization and exogenous hormone rescue of bromodichloromethane-induced pregnancy loss in the F344 rat. Toxicol Sci. (in press).
6. Bielmeier, S. R., Murr, A. S., Best, D. S., Goldman, J. M., and Narotsky, M. G. (2003). Effects of bromodichloromethane (BDCM) on ex vivo luteal function in the pregnant F344 rat. Toxicologist 72(S-1), 26-27.
7. Boorman, G. A. (1999). Drinking water disinfection byproducts: Review and approach to toxicity evaluation. Environ. Health Perspect. 107(Suppl. 1), 207-217.
8. Bove, F. J., Fulcomer, M. C., Klotz, J. B., Esmart, J., Dufficy, E. M., and Savrin, J. E. (1995). Public drinking water contamination and birth outcomes. Am. J. Epidemiol. 141, 850-862.
9. Canfield, R. E., O'Connor, J. F., Birken, S., Krichevsky, A., and Wilcox, A. J. (1987). Development of an assay for a biomarker of pregnancy and early fetal loss. Environ. Health Perspect. 74, 57-66.
10. Cantor, K. P., Lynch, C. F., Hildesheim, M. E., Dosemeci, M., Lubin, J., Alavanja, M., and Craun, G. (1999). Drinking water source and chlorination byproducts in Iowa. III. Risk of brain cancer. Am. J. Epidemiol. 150, 552-560.
11. Chen, J., Douglas, G. C., Thirkill, T. L., Lohstroh, P. N., Bielmeier, S. R., Narotsky, M. G., Best, D. S., Harrison, R. A., Natarajan, K., Pegram, R. A., et al. (2003a). Effect of bromodichloromethane on chorionic gonadotrophin secretion by human placental trophoblast cultures. Toxicol. Sci. 76, 75-82.
12. Chen, J., Thirkill, T. L., Overstreet, J. W., Lasley, B. L., and Douglas, G. C. (2003b). Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on chorionic gonadotropin secretion by human trophoblasts. Reprod. Toxicol. 17, 87-93.
13. Cheng, K. W., Nathwani, P. S., and Leung, P. C. (2000). Regulation of human gonadotropin-releasing hormone receptor gene expression in placental cells. Endocrinology 141, 2340-2349.
14. Christian, M. S., York, R. G., Hoberman, A. M., Diener, R. M., and Fisher, L. C. (2001). Oral (drinking water) developmental toxicity studies of bromodichloromethane (BDCM) in rats and rabbits. Int. J. Toxicol. 20, 225-237.
15. Chu, I., Villeneuve, D. C., Secours, V. E., Becking, G. C., and Valli, V. E. (1982). Trihalomethanes: II. Reversibility of toxicological changes produced by chloroform, bromodichloromethane, chlorodibromomethane and bromoform in rats. J. Environ. Sci. Health B 17, 225-240.
16. Cronier, L., Bastide, B., Herve, J. C., Deleze, J., and Malassine, A. (1994). Gap junctional communication during human trophoblast differentiation: Influence of human chorionic gonadotropin. Endocrinology 135, 402-408.
17. Cronier, L., Bois, P., Herve, J. C., and Malassine, A. (1995). Effect of human chorionic gonadotrophin on chloride current in human syncytiotrophoblasts in culture. Placenta 16, 599-609.
18. Dakour, J., Li, H., Chen, H., and Morrish, D. W. (1999). EGF promotes development of a differentiated trophoblast phenotype having c-myc and junB proto-oncognene activation. Placenta 20, 119-126.
19. Deinzer, M. S., Schaumburg, F., Klein, E. (1978). Environmental Health Sciences Center Task Force review on halogenated organics in drinking water. Environ. Health Perspect. 24, 209-239.
20. Dodds, L., King, W., Woolcott, C., and Pole, J. (1999). Trihalomethanes in public water supplies and adverse birth outcomes. Epidemiology 10, 233-237.
21. Douglas, G. C., and King, B. F. (1989). Isolation of pure villous cytotrophoblast from term human placenta using immunomagnetic microspheres. J. Immunol. Methods 119, 259-268.
22. Douglas, G. C., and King, B. F. (1990). Differentiation of human trophoblast cells in vitro as revealed by immunocytochemical staining of desmoplakin and nuclei. J. Cell Sci. 96, 131-141.
23. Douglas, G. C., and King, B. F. (1993). Colchicine inhibits human trophoblast differentiation in vitro. Placenta 14, 187-201.
24. Dunnick, J. K., and Melnick, R. L. (1993). Assessment of the carcinogenic potential of chlorinated water: Experimental studies of chlorine, chloramine, and trihalomethanes. J. Natl. Cancer Inst. 85, 817-822.
25. Enders, A. C. (1965). Formation of syncytium from cytotrophoblast in the human placenta. Obstet. Gynecol. 25, 378-386.
26. Gallagher, M. D., Nuckols, J. R., Stallones, L., and Savitz, D. A. (1998). Exposure to trihalomethanes and adverse pregnancy outcomes. Epidemiology 9, 484-489.
27. Guo, Y., Hendrickx, A. G., Overstreet, J. W., Dieter, J., Stewart, D., Tarantal, A. F., Laughlin, L., and Lasley, B. L. (1999). Endocrine biomarkers of early fetal loss in cynomolgus macaques (Macaca fascicularis) following exposure to dioxin. Biol. Reprod. 60, 707-713.
28. Hildesheim, M. E., Cantor, K. P., Lynch, C. F., Dosemeci, M., Lubin, J., Alavanja, M., and Craun, G. (1998). Drinking water source and chlorination byproducts. II. Risk of colon and rectal cancers. Epidemiology 9, 29-35.
29. Ho, H. H., Douglas, G. C., Qiu, Q. F., Thirkill, T. L., Overstreet, J. W., and Lasley, B. L. (1997a). The relationship between trophoblast differentiation and the production of bioactive hCG. Early Pregnancy 3, 291-300.
30. Ho, H. H., O'Connor, J. F., Nakajima, S. T., Tieu, J., Overstreet, J. W., and Lasley, B. L. (1997b). Characterization of human chorionic gonadotropin in normal and abnormal pregnancies. Early Pregnancy 3, 213-224.
31. Hoshina, M., Boothby, M., Hussa, R., Pattillo, R., Camel, H. M., and Boime, I. (1985). Linkage of human chorionic gonadotrophin and placental lactogen biosynthesis to trophoblast differentiation and tumorigenesis. Placenta 6, 163-172.
32. Jia, X. C., Oikawa, M., Bo, M., Tanaka, T., Ny, T., Boime, I., and Hsueh, A. J. (1991). Expression of human luteinizing hormone (LH) receptor: Interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species. Mol. Endocrinol. 5, 759-768.
33. Keegan, T. E., Simmons, J. E., and Pegram, R. A. (1998). NOAEL and LOAEL determinations of acute hepatotoxicity for chloroform and bromodichloromethane delivered in an aqueous vehicle to F344 rats. J. Toxicol. Environ. Health A 55, 65-75.
34. King, W. D., and Marrett, L. D. (1996). Case-control study of bladder cancer and chlorination by-products in treated water (Ontario, Canada). Cancer Causes Control 7, 596-604.
35. Kliman, H. J., Feinman, M. A., and Strauss, J. F., III (1987). Differentiation of human cytotrophoblast to syncytiotrophoblast in culture. Trophobl. Res. 2, 407-421.
36. Kliman, H. J., Nestler, J. E., Sermasi, E., Sanger, J. M., and Strauss, J. F., III (1986). Purification, characterization and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 118, 1567-1582.
37. Kramer, M. D., Lynch, C. F., Isacson, P., and Hanson, J. W. (1992). The association of waterborne chloroform with intrauterine growth retardation. Epidemiology 3, 407-413.
38. Lin, L. S., Roberts, V. J., and Yen, S. S. (1995). Expression of human gonadotropin-releasing hormone receptor gene in the placenta and its functional relationship to human chorionic gonadotropin secretion. J. Clin. Endocrinol. Metab. 80, 580-585.
39. Midgley, A. R., Pierce, G. B., Deneau, G. A., and Gosling, J. R. G. (1963). Morphogenesis of syncytiotrophoblast in vivo: An autoradiographic demonstration. Science 141, 349-350.
40. Miles, A. M., Singer, P. C., Ashley, D. L., Lynberg, M. C., Mendola, P., Langlois, P. H., and Nuckols, J. R. (2002). Comparison of trihalomethanes in tap water and blood. Environ. Sci. Technol. 36, 1692-1698.
41. Morrish, D. W., Bhardwaj, D., Dabbagh, L. K., Marusyk, H., and Siy, O. (1987). Epidermal growth factor induces differentiation and secretion of human chorionic gonadotropin and placental lactogen in normal human placenta. J. Clin. Endocrinol. Metab. 65, 1282-1290.
42. Morrish, D. W., Bhardwaj, D., and Paras, M. T. (1991). Transforming growth factor α1 inhibits placental differentiation and human chorionic gonadotropin and human placental lactogen secretion. Endocrinology 129, 22-26.
43. Morrish, D. W., Dakour, J., and Li, H. (1998). Functional regulation of human trophoblast differentiation. J. Reprod. Immunol. 39, 179-195.
44. Morrish, D. W., Linetsky, E., Bhardwaj, D., Li, H., Dakour, J., Marsh, R. G., Paterson, M. C., and Godbout, R. (1996). Identification by subtractive hybridization of a spectrum of novel and unexpected genes associated with in vitro differentiation of human cytotrophoblast cells. Placenta 17, 431-441.
45. Narotsky, M. G., and Kavlock, R. J. (1995). A multidisciplinary approach to toxicological screening: II. Developmental toxicity. J. Toxicol. Environ. Health 45, 145-171.
46. Narotsky, M. G., Pegram, R. A., and Kavlock, R. J. (1997). Effect of dosing vehicle on the developmental toxicity of bromodichloromethane and carbon tetrachloride in rats. Fundam. Appl. Toxicol. 40, 30-36.
47. O'Connor, J. F., Schlatterer, J. P., Birken, S., Krichevsky, A., Armstrong, E. G., McMahon, D., and Canfield, R. E. (1988). Development of highly sensitive immunoassays to measure human chorionic gonadotropin, its beta-subunit, and beta core fragment in the urine: application to malignancies. Cancer Res. 48, 1361-1366.
48. Ruddick, J. A., Villeneuve, D. C., Chu, I., and Valli, V. E. (1983). A teratological assessment of four trihalomethanes in the rat. J. Environ. Sci. Health B 18, 333-349.
49. Savitz, D. A., Andrews, K. W., and Pastore, L. M. (1995). Drinking water and pregnancy outcome in central North Carolina: Source, amount, and trihalomethane levels. Environ. Health Perspect. 103, 592-596.
50. Scholz, D., Devaux, B., Hirche, A., Potzsch, B., Kropp, B., Schaper, W., and Schaper, J. (1996). Expression of adhesion molecules is specific and time-dependent in cytokine-stimulated endothelial cells in culture. Cell Tissue Res. 284, 415-423.
51. Swan, S. H., Waller, K., Hopkins, B., Windham, G., Fenster, L., Schaefer, C., and Neutra, R. R. (1998). A prospective study of spontaneous abortion: Relation to amount and source of drinking water consumed in early pregnancy. Epidemiology 9, 126-133.
52. Taylor, C. A., Jr., Overstreet, J. W., Samuels, S. J., Boyers, S. P., Canfield, R. E., O'Connor, J. F., Hanson, F. W., and Lasley, B. L. (1992). Prospective assessment of early fetal loss using an immunoenzymometric screening assay for detection of urinary human chorionic gonadotropin. Fertil. Steril. 57, 1220-1224.
53. Thirkill, T. L., and Douglas, G. C. (1997). Differentiation of human trophoblast cells in vitro is inhibited by dimethyl sulfoxide. J. Cell. Biochem. 65, 460-468.
54. Thornton-Manning, J. R., Seely, J. C., and Pegram, R. A. (1994). Toxicity of bromodichloromethane in female rats and mice after repeated oral dosing. Toxicology 94, 3-18.
55. Torti, V. R., Cobb, A. J., Everitt, J. I., Marshall, M. W., Boorman, G. A., and Butterworth, B. E. (2001). Nephrotoxicity and hepatotoxicity induced by inhaled bromodichloromethane in wild-type and p53-heterozygous mice. Toxicol. Sci. 64, 269-280.
56. Toussaint, M. W., Rosencrance, A. B., Brennan, L. M., Dennis, W. E., Beaman, J. R., Wolfe, M. J., Hoffmann, F. J., and Gardner, H. S., Jr. (2001). Chronic toxicity of bromodichloromethane to the Japanese medaka (Oryzias latipes). Toxicol. Pathol. 29, 662-669.
57. Villanueva, C., Kogevinas, M., and Grimalt, J. (2001). Chlorination of drinking water in Spain and bladder cancer. Gac. Sanit. 15, 48-53.
58. Waller, K., Swan, S. H., DeLorenze, G., and Hopkins, B. (1998). Trihalomethanes in drinking water and spontaneous abortion. Epidemiology 9, 134-140.
59. Wolfahrt, S., Kleine, B., and Rossmanith, W. G. (1998). Detection of gonadotrophin releasing hormone and its receptor mRNA in human placental trophoblasts using in-situ reverse transcription-polymerase chain reaction. Mol. Hum. Reprod. 4, 999-1006.
60. Yang, M., Lei, Z. M., and Rao, Ch. V. (2003). The central role of human chorionic gonadotropin in the formation of human placental syncytium. Endocrinology 144, 1108-1120.