Effect of different dispersing agents on the characteristics of Eudragit microspheres prepared by a solvent evaporation method

Journal of Microencapsulation

Volumn 21, Issue 2, 2004, Pages 191-202

  Horoz, B B ^a   Kilicarslan M ^a   Yuksel N ^a   Baykara, Tamer ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Dispersing agent; Eudragit RS 100; Multiple linear regression; Polymeric microspheres; Solvent evaporation method

Indexed keywords

ACETONE; ALUMINUM DERIVATIVE; EUDRAGIT RS; LIQUID PARAFFIN; MAGNESIUM STEARATE; METHANOL; MICROSPHERE; POLYMER; SOLVENT; STEARIC ACID DERIVATIVE; SUCROSE; TRITON X 114; VERAPAMIL;

ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION FUNCTION; DISPERSION; DRUG FORMULATION; DRUG RELEASE; EVAPORATION; HYDROPHOBICITY; LINEAR REGRESSION ANALYSIS; MEDICAL INSTRUMENTATION; MICROMORPHOLOGY; PARTICLE SIZE; POROSITY; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; TIME;

ACRYLIC RESINS; DRUG COMPOUNDING; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; SOLVENTS; STEARIC ACIDS; SUCROSE; SURFACE PROPERTIES; VERAPAMIL;

EID: 12144289442     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.1080/02652040310001637893     Document Type: Article

References (22)

1. Arshady, R., 1990, Microspheres and microcapsules, a survey of manufacturing techniques: Part III: Solvent evaporation. Polymer Engineering and Science, 30, 915-924.
2. Bezemer, J. M., Radersma, R., Grijpma, D. W., Dijkstra, P. J., Blitterswijk, C. A. and Feijen, J., 2000, Microspheres for protein delivery prepared from amphiphilic multiblock copolymers, 1. Influence of preparation techniques on particle characteristics and protein delivery. Journal of Controlled Release, 67, 233-248.
3. Blanco, D. and Alonso, M. J., 1998, Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: Effect of the protein and polymer properties and of the co-encapsulation of surfactants. European Journal of Pharmaceutics and Biopharmaceutics, 45, 285-294.
4. Blanco-Prieto, M. J., Leo, E., Delie, F., Gulik, A., Couvreur, P. and Fattal, E., 1996, Study of the influence of several stabilizing agents on the entrapment and in vitro release of pBC 264 from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent evaporation method. Pharmaceutical Research, 13, 1127-1129.
5. 125I-bovine calcitonin from PLGA microspheres: In vitro - in vivo study. Journal of Controlled Release, 43, 59-64.
6. Jalil, R. and Nixon, J. R., 1989, Microencapsulation using poly(L-lactic acid) I: Microcapsule properties affected by the preparative techniques. Journal of Microencapsulation, 6, 473-484.
7. Jalil, R. and Nixon, J. R., 1990, Microencapsulation using poly(L-lactic acid) II: Preparative variables affecting microcapsule properties. Journal of Microencapsulation, 7, 25-39.
8. Jones, D. S. and Pearce, K. J., 1996, Contribution of process variables to the entrapment efficiency of propranolol hydrochloride within ethylcellulose microspheres prepared by the Solvent evaporation method as evaluated using a factorial design. International Journal of Pharmaceutics, 131, 25-31.
9. Kawata, M., Nakamuro, M., Goto, S. and Aoyama, T., 1986, Preparation and dissolution pattern of Eudragit RS microcapsules containing ketoprofen. Chemical Pharmaceutical Bulletin, 34, 2618-2623.
10. Kiliçarslan, M. and Baykara, T., 2003, The effect of the drug/polymer ratio on the properties of the verapamil HCl loaded microspheres. International Journal of Pharmaceutics, 252, 99-109.
11. Kim, C. K., Kim, M. J. and Oh, K. H., 1994, Preparation and evaluation of sustained release microspheres of terbutaline sulfate. International Journal of Pharmaceutics, 106, 213-219.
12. Lambert, O., Nagele, O., Loux, V., Bonny, J. D. and Marchal-Heussler, L., 2000, Poly(ethylene carbonate) microspheres: manufacturing process and internal structure characterization. Journal of Controlled Release, 67, 89-99.
13. Langenbucher, F., 1976, Parametric representation of dissolution-rate curves by the RRSBW distribution. Pharmaceutical Industry, 38, 472-477.
14. Morlock, M., Koll, H., Winter, G. and Kissel, T., 1997, Microencapsulation of rh-erythropoietin, using biodegradable poly(D,L-lactide-co-glycolide): Protein stability and the effects of stabilizing excipients. European Journal of Pharmaceutics and Biopharmaceutics, 43, 29-36.
15. Ntawukulilyayo, J. D., Bouckaert, S. and Remon, J. P., 1993, Enhancement of dissolution rate of nifedipine using sucrose ester coprecipitates. International Journal of Pharmaceutics, 93, 209-214.
16. Pongpaibul, Y., Maruyama, K. and Iwatsuru, M., 1988, Formation and in-vitro evaluation of theophylline-loaded poly(methyl methacrylate) microspheres. Journal of Pharmaceutics and Pharmacology, 40, 530-533.
17. Pradhan, R. S. and Vasavada, R. C., 1994, Formulation and in vitro release study on poly (DL-lactide) microspheres containing hydrophilic compounds: Glycine homopeptides. Journal of Controlled Release, 30, 143-154.
18. Sansdrap, P. and Moës, A. J., 1993, Influence of manufacturing parameters on the size characteristics and the release profiles of nifedipine from poly(DL-lactide-co-glycolide) microspheres. International Journal of Pharmaceutics, 98, 157-164.
19. Tcancov, St., Lambov, N. and Minkov, E., 1991, Preparation of tinidazol microspheres using polyacrylate resins. Pharmazeutische Industry, 53, 695-698.
20. Yüksel, N. and Baykara, T., 1996, Preparation and evaluation of controlled release microspheres containing nicardipine hydrochloride. International Journal of Pharmaceutical Advances, 1, 398-407.
21. Yüksel, N. and Baykara, T., 1997, Preparation of polymeric microspheres by the solvent evaporation method using sucrose stearate as a droplet stabilizer. Journal of Microencapsulation, 14, 725-733.
22. Yüksel, N., Türkoglu, M. and Baykara, T., 2000, Modelling of the solvent evaporation method for the preparation of controlled release acrylic microspheres using neural networks. Journal of Microencapsulation, 17, 541-551.