Biochemical characterization of terbinafine-resistant Trichophyton rubrum isolates

Medical Mycology

Volumn 42, Issue 6, 2004, Pages 525-529

  Favre, Bertrand ^a,c   Ghannoum, Mahmoud A ^b   Ryder, Neil S ^a,d  

^a NOVARTIS RESEARCH INSTITUTE   (Austria)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Dermatophyte; Resistance; Terbinafine; Trichophyton

Indexed keywords

AMOROLFINE; ERGOSTEROL; SQUALENE MONOOXYGENASE; TERBINAFINE; TOLNAFTATE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; FUNGAL STRAIN; FUNGUS ISOLATION; NONHUMAN; SENSITIVITY ANALYSIS; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STEROL SYNTHESIS; TRICHOPHYTON RUBRUM;

ANTIFUNGAL AGENTS; DRUG RESISTANCE, FUNGAL; ERGOSTEROL; HUMANS; NAPHTHALENES; OXYGENASES; SQUALENE MONOOXYGENASE; TOLNAFTATE; TRICHOPHYTON;

TRICHOPHYTON; TRICHOPHYTON RUBRUM;

EID: 12144276530     PISSN: 13693786     EISSN: None     Source Type: Journal    
DOI: 10.1080/13693780410001661482     Document Type: Article

References (15)

1. Ryder NS. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol 1992; 126(Suppl. 39): 2-7.
2. Ryder NS, Frank I, Dupont MC. Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother 1986; 29: 858-860.
3. Ryder NS, Mieth H. Allylamine antifungal drugs. Curr Top Med Mycol 1992; 4: 158-188.
4. Mukherjee PK, Leidich SD, Isham I, Leitner I, Ryder NS, Ghannoum MA. Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. Antimicrob Agents Chemother 2003; 47 82-86.
5. Favre B, Ryder NS. Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob Agents Chemother 1996; 40: 443-447.
6. Ryder NS. Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agent. Antimicrob Agents Chemother 1985; 27: 252-256.
7. Favre B, Didmon M, Ryder NS. Multiple amino acid substitutions in lanosterol 14α-demethylase contribute to azole resistance in Candida albicans. Microbiology 1999; 145: 2715-2725.
8. Balkis MM, Leidich SD, Mukherjee PK, Ghannoum MA. Mechanisms of fungal resistance: an overview. Drugs 2002; 62: 1025-1040.
9. Sanglard D, Ischer F, Monod M, Bille J. Cloning of Candida albicans genes conferring resistance to azole antifungal agents:characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 1997; 143: 405-416.
10. Polak A. Preclinical data and mode of action of amorolfine. Dermatology 1992; 184(Suppl. 1): 3-7.
11. Bradley MC, Leidich S, Isham N, Elewski BE, Ghannoum MA. Antifungal susceptibilities and genetic relatedness of serial Trichophyton rubrum isolates from patients with onychomycosis of the toenail. Mycoses 1999; 42(Suppl. 2): 105-110.
12. Fernández-Torres B, Carrillo AJ, Martín E, et al. In vitro activities of 10 antifungal drugs against 508 dermatophyte strains. Antimicrob Agents Chemother 2001; 45: 2524-2528.
13. Jandrositz A, Turnowsky F, Hogenauer G. The gene encoding squalene epoxidase from Saccharomyces cerevisiae: cloning and characterization. Gene 1991; 107: 155-160.
14. Favre B, Ryder NS. Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans. Gene 1997; 189: 119-126.
15. Klobucnikova V, Kohut P, Leber R, et al. Terbinafine resistance in a pleiotropic yeast mutant is caused by a single point mutation in the ERG1 gene. Biochem Biophys Res Comm 2003; 309 666-671.