Central dexmedetomidine attenuates cardiac dysfunction in a rodent model of intracranial hypertension

Canadian Journal of Anesthesia

Volumn 51, Issue 10, 2004, Pages 1025-1033

  Hall, Sean R R ^a   Wang, Louie ^a   Milne, Brian ^a   Hong, Murray ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CAPNOMAC ULTIMA; CATECHOLAMINE DERIVATIVE; DEXMEDETOMIDINE; HALOTHANE; LIPID; MALONALDEHYDE; MEDETOMIDINE; NORADRENALIN; OXYGEN; VECURONIUM;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BALLOON CATHETER; CATECHOLAMINE BLOOD LEVEL; CENTRAL NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; DECELERATION; DETERIORATION; DISEASE ASSOCIATION; DRUG MECHANISM; DURA MATER; ECG ABNORMALITY; ELECTROCARDIOGRAPHY; HEART ARRHYTHMIA; HEART DISEASE; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE; HEART RATE; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; RAT; RECORDING; STEREOISOMERISM; SYMPATHETIC BLOCKING; SYSTOLIC BLOOD PRESSURE;

EID: 12144256302     PISSN: 0832610X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03018493     Document Type: Article

References (39)

1. Dujardin KS, McCully RB, Wijdicks EF, et al. Myocardial dysfunction associated with brain death: clinical, echocardiographic, and pathologic features. J Heart Lung Transplant 2001; 20: 350-7.
2. Huttemann E, Schelenz C, Chatzinikolaou K, Reinhart K. Left ventricular dysfunction in lethal severe brain injury: impact of transesophageal echocardiography on patient management. Intensive Care Med 2002; 28: 1084-8.
3. Bratton SL, Davis RL. Acute lung injury in isolated traumatic brain injury. Neurosurgery 1997; 40: 707-12.
4. Gilbert EM, Krueger SK, Murray JL, et al. Echocardiographic evaluation of potential cardiac transplant donors. J Thorac Cardiovasc Surg 1988; 95: 1003-7.
5. Busson M, N'Doye P, Benoit G, et al. Donor factors influencing organ transplant prognosis. Transplant Proc 1995; 27: 1662-4.
6. Nygaard CE, Townsend RN, Diamond DL. Organ donor management and organ outcome: a 6-year review from a level I trauma center. J Trauma 1990; 30: 728-32.
7. Tsai FC, Marelli D, Bresson J, et al. Use of hearts transplanted from donors with atraumatic intracranial bleeds. J Heart Lung Transplant 2002; 21: 623-8.
8. Novitzky D, Wicomb NW, Cooper DK, Rose AG, Fraser RC, Barnard CN. Electrocardiographic, hemodynamic and endocrine changes occuring during experimental brain death in the Chacma baboon. Heart Transplant 1984; 4: 63-9.
9. Shanlin RJ, Sole MJ, Rahimifar M, Tator CH, Factor SM. Increased intracranial pressure elicits hypertension, increased sympathetic activity, electrocardiographic abnormalities and myocardial damage in rats. J Am Coll Cardiol 1988; 12: 727-36.
10. Graf CJ, Rossi NP. Catecholamine response to intracranial hypertension. J Neurosurg 1978; 49: 862-8.
11. Novitzky D, Rhodin J, Cooper DK, Ye Y, Min KW, DeBault L. Ultrastructure changes associated with brain death in the human donor heart. Transpl Int 1997; 10: 24-32.
12. Novitzky D, Wicomb WW, Cooper DK, Rose AG, Reichart B. Prevention of myocardial injury during brain death by total cardiac sympathectomy in the Chacma baboon. Ann Thorac Surg 1986; 41: 520-4.
13. Shivalkar B, Van Loon J, Wieland W, et al. Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function. Circulation 1993; 87: 230-9.
14. White M, Wiechmann RJ, Roden RL, et al. Cardiac β-adrenergic neuroeffector systems in acute myocardial dysfunction related to brain injury. Evidence for catecholamine-mediated myocardial damage. Circulation 1995; 92: 2183-9.
15. Rona G. Catecholamine cardiotoxicity (Editorial). J Mol Cell Cardiol 1985; 17: 291-306.
16. Dampney RA, Kumada M, Reis DJ. Central neural mechanisms of the cerebral ischemic response. Characterization, effect of brainstem and cranial nerve transections, and simulation by electrical stimulation of restricted regions of medulla oblongata in rabbit. Circ Res 1979; 44: 48-62.
17. Dampney RA, Moon EA. Role of ventrolateral medulla in vasomotor response to cerebral ischemia. Am J Physiol 1980; 239: H349-58.
18. 2-adrenergic agonist medetomidine on in vivo catechol activity in the rat rostral ventrolateral medulla (RVLM). Brain Res 1992; 592: 163-9.
19. Punnen S, Urbanski R, Krieger AJ, Sapru HN. Ventrolateral medullary pressor area: site of hypotensive action of clonidine. Brain Res 1987; 422: 336-46.
20. 1-selective blockade. Lancet 1987; 2: 585-9.
21. Hunt D, Gore I. Myocardial lesions following experimental intracranial hemorrhage: prevention with propranolol. Am Heart J 1972; 83: 232-6.
22. Hall SR, Wang L, Milne B, Ford S, Hong M. Intrathecal lidocaine prevents cardiovascular collapse and neurogenic pulmonary edema in a rat model of acute intracranial hypertension. Anesth Analg 2002; 94: 948-53.
23. Farber NE, Samso E, Staunton M, Schwabe D, Schmeling WT. Dexmedetomidine modulates cardiovascular responses to stimulation of central nervous system pressor sites. Anesth Analg 1999; 88: 617-24.
24. max, a preload-independent index of contractility: open-chest dog study. Basic Res Cardiol 1996; 91: 94-100.
25. Weiss JL, Frederiksen JW, Weisfeldt ML. Hemodynamic determinants of the time-course of fall in canine left ventricular pressure. J Clin Invest 1976; 58: 751-60.
26. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978; 52: 302-10.
27. Clifton GL, Robertson CS, Kyper K, Taylor AA, Dhekne RD, Grossman RG. Cardiovascular response to severe head injury. J Neurosurg 1983; 59: 447-54.
28. Powner DJ, Hendrich A, Nyhuis A, Strate R. Changes in serum catecholamine levels in patients who are brain dead. J Heart Lung Transplant 1992; 11: 1046-53.
29. Herijgers P, Leunens V, Tjandra-Maga TB, Mubagwa K, Flameng W. Changes in organ perfusion after brain death in the rat and its relation to circulating catecholamines. Transplantation 1996; 62: 330-5.
30. Di Pasquale G, Pinelli G, Andreoli A, Manini G, Grazi P, Tognetti F. Holter detection of cardiac arrhythmias in intracranial subarachnoid hemorrhage. Am J Cardiol 1987; 59: 596-600.
31. Yamour BJ, Sridharan MR, Rice JF, Flowers NC. Electrocardiographic changes in cerebrovascular hemorrhage. Am Heart J 1980; 99: 294-300.
32. Gutteridge JM, Halliwell B. The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci 1990; 15: 129-35.
33. Tolden DV, Gupta A, Sharma AC, Li SY, Saari JT, Ren J. Malondialdehyde inhibits cardiac contractile function in ventricular myocytes via a p38 mitogen-activated protein kinase-dependent mechanism. Br J Pharmacol 2003; 139: 1310-6.
34. Dhalla NS, Temsah RM, Netticadan T. Role of oxidative stress in cardiovascular diseases. J Hypertens; 2000; 18: 655-73.
35. Rupp H, Dhalla KS, Dhalla NS. Mechanisms of cardiac cell damage due to catecholamines: significance of drugs regulating central sympathetic outflow. J Cardiovasc Pharmacol 1994; 24(Suppl 1): S16-24.
36. Hort M, Gotoh K, Kitakaze M, et al. Role of oxygen-derived free radicals in myocardial edema and ischemia in coronary microvascular embolization. Circulation 1991; 84: 828-40.
37. 2+-pump, activity by oxygen free radicals. Am J Physiol 1989; 256: H368-74.
38. 2+ pump by oxygen free radicals. Am J Physiol 1989; 257: H804-11.
39. 2+ transport. Arch Biochem Biophys 2001; 387: 85-92.