Production of structured triacylglycerols in an immobilised lipase packed-bed reactor: Batch mode operation

Journal of Chemical Technology and Biotechnology

Volumn 80, Issue 1, 2005, Pages 35-43

  Gonzalez Moreno P A ^a   Robles Medina, A ^a   Camacho Rubio, F ^b   Camacho Paez B ^a   Esteban Cerdan L ^a   Molina Grima, E ^a  

^a UNIVERSITY OF ALMERÍA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Acidolysis (interestrification); Caprylic acid; Eicosapentaenoic acid (EPA); Kinetics; Lipase; Packed bred reactor; Polyunsaturated fatty acid; Recirculation; Structured triacylglycerols

Indexed keywords

BIOREACTORS; CATALYSIS; COMPOSITION; ENZYMES; FATTY ACIDS; OILS AND FATS; PACKED BEDS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

ACIDOLYSIS; CAPRYLIC ACID; POLYUNSATURATED FATTY ACIDS (PUFA); STRUCTURED TRIACYLGLYCEROLS;

GLYCEROL;

DOCOSAHEXAENOIC ACID; FATTY ACID; ICOSAPENTAENOIC ACID; OCTANOIC ACID; OLEIC ACID; OMEGA 3 FATTY ACID; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE;

BIOREACTOR; PACKED BED;

ARTICLE; BATCH REACTOR; CALCULATION; CATALYSIS; CHEMICAL REACTION KINETICS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMPIRICISM; EQUILIBRIUM CONSTANT; FLOW RATE; LIPID COMPOSITION; LIPOGENESIS; PACKED BED REACTOR; PREDICTION; REACTION TIME;

EID: 11844294936     PISSN: 02682575     EISSN: None     Source Type: Journal    
DOI: 10.1002/jctb.1149     Document Type: Article

References (25)

1. Xu X, Hoy C-E, Blachen S and Ander-Nissen J, Specific-structured lipid: nutritional perspectives and production potentials, in Proceedings of International Symposium on the Approaches to Functional Cereals and Oils. CCOA, Beijing, pp 806-813 (1997).
2. Xu X, Production of specific-structured triacylglycerols by lipase-catalyzed reactions: a review. Eur J Lipid Sci Technol: 287-303 (2000).
3. Christensen MS, Hoy CE, Becker CC and Redgrave TG, Intestinal absorption and lymphatic transport of eicosapentaenoic (EPA), docosahexaenoic (DHA), and decanoic acids: dependence on intramolecular triacylglycerol structure. Am J Nutr 61:56-61 (1995).
4. Kennedy K, Fewtrell MS, Morley R, Abbott R, Quinlan PT, Wells JCK, Bindels JG and Lucas A, Double-blind, randomized trial of a synthetic triacylglycerol in formula-fed term infants: effects on stool biochemistry, stool characteristics, and bone mineralization. Am J Clin Nutr 70:920-927 (1999).
5. Bottino NR, Vandenburg GA and Reiser R, Resistance of certain long-chain polyunsaturated fatty acids of marine oils to pancreatic lipase hydrolysis. Lipids 2:489-493 (1967).
6. Jandacek RJ, Whiteside JA, Holcombe BN, Volpenheim RA and Taulbee JD, The rapid hydrolysis and efficient absorption of triglycerides with octanoic acid in the 1 and 3 positions and long-chain fatty acid in the 2 position. Am J Clin Nutr 45:940-945 (1987).
7. Shimada Y, Sugihara A, Nakano H, Yokota T, Nagao T, Komemushi S and Tominaga Y, Production of structured lipids containing essential fatty acids by immobilized Rhizopus delemar lipase. J Am Oil Chem Soc 73:1415-1420 (1996).
8. Shimada Y, Sugihara A, Maruyama K, Nagao T, Nakayama S, Nakano H and Tominaga Y, Production of structured lipid containing docosahexaenoic and caprylic acids using immobilized Rhizopus delemar lipase. J Ferment Bioeng 81:299-303 (1996).
9. Shimada Y, Suenaga M, Sugihara A, Nakai S and Tominaga Y, Continuous production of structured lipid containing γ-linolenic and caprylic acids by immobilised Rhizopus delemar lipase. J Am Oil Chem Soc 76:189-193 (1999).
10. Akoh CC and Huang KH, Enzymatic synthesis of structured lipids: transesterification of triolein and caprylic acid. J Food Lipids 2:219-230 (1995).
11. Xu X, Balchen S, Høy CE and Adler-Nissen J, Pilot batch production of specific-structured lipids by lipase-catalyzed interesterification: preliminary study on incorporation and acyl migration. J Am Oil Chem Soc 75:301-308 (1998).
12. Mu H, Xu X and Høy C-E, Production of specific-structured triacylglycerols by lipase-catalyzed interesterification in a laboratory-scale continuous reactor. J Am Oil Chem Soc 75 1187-1193 (1998).
13. Reyes HR and Hill CG, Kinetic modeling of interesterification reactions catalyzed by immobilized lipase. Biotechnol Bioeng 43 171-182 (1994).
14. Camacho Páez B, Robles Medina A, Camacho Rubio F, González Moreno P and Molina Grima E, Production of structured triglycerides rich in n-3 polyunsaturated fatty acids by the acidolysis of cod liver oil and caprylic acid in a packed-bed reactor: equilibrium and kinetics. Chem Eng Sci 57:1237-1249 (2002).
15. Robles Medina A, Esteban Cerdán L, Giménez Giménez A, Camacho Páez B, Ibáñez González MJ and Molina Grima E, Lipase-catalyzed esterification of glycerol and polyunsaturated fatty acids from fish and microalgae oils. J Biotechnol 70:379-391 (1999).
16. Lepage G and Roy C, Improved recovery of fatty acid through direct transesterification without prior extraction or purification. J Lipid Res 25:1391-1396 (1984).
17. Robles Medina A, Giménez Giménez A, García Camacho F, Sánchez Pérez JA, Molina Grima E and Contreras Gó mez A, Concentration and purification of stearidonic, eicosapentaenoic, and docosahexaenoic acids from cod liver oil and the marine microalga Isochrysis galbana. J Am Oil Chem Soc 72:575-583 (1995).
18. Belarbi H, Molina E and Chisti Y, A process for high yield and scaleable recovery of high purity eicosapentaenoic acid esters from microalgae and fish oil. Process Biochemistry 35:951-969 (2000).
19. Millqvist Fureby A, Virto C, Adlercreutz P and Mattiasson B, Acyl group migration in 2-monoolein. Biocatal Biotrans 14 89-111 (1996).
20. Serdarevich B, Glyceride isomerization in lipid chemistry. J Am Oil Chem Soc 44:381-393 (1967).
21. Ainsworth S, Versteeg C, Plamer M and Millikan MB, Enzymatic interesterification of fats. Milkfat Update Conference, 27-28 February 1996, Werribee, Victoria (Australia). Australian J Dairy Technol 51:105-107 (1996).
22. González Moreno PA, Robles Medina A, Camacho Rubio F, Camacho Páez B and Molina Grima E, Production of structured lipids by acidolysis of an EPA enriched fish oil and caprylic acid in a packed bed reactor: analysis of three different operation modes. Biotechnol Prog 20:1044-1052 (2004).
23. Ison AP, Macrae AR, Smith CG and Bosley J, Mass transfer effects in solvent free fat interesterification reactions: influences on catalyst design. Biotechnol Bioeng 43:122-130 (1994).
24. Perry RH and Chilton CH (eds), Chemical Engineers Handbook 5th edn. McGraw-Hill, New York, pp 3-234 (1973).
25. Camacho Páez B, Obtención de lípidos estructurados por acidolisis con lipasas immovilizadas. Doctoral thesis, Departamento de Ingeniería Química, Universidad de Almería (2000).