In vivo activity of the potent oxytocin antagonist on uterine activity in the rat

In Vivo

Volumn 18, Issue 6, 2004, Pages 763-766

  Ahn, Tae Gyu ^a   Han, Sei Jun ^a   Cho, Young Shin ^a   An, Tae Hun ^a   Pak, Sok Cheon ^b   Flouret, George ^c  

^a Chosun University   (South Korea)

^b Hamilton College of Oriental Medicine   (New Zealand)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Oxytocin; Oxytocin antagonist; Uterus

Indexed keywords

OXYTOCIN; OXYTOCIN ANTAGONIST; OXYTOCIN RECEPTOR; TT 235; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BOLUS INJECTION; CANNULATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ESTRUS; FEMALE; IN VIVO STUDY; JUGULAR VEIN; NONHUMAN; RAT; UTERUS CONTRACTILITY; UTERUS HORN; VEIN CATHETERIZATION;

EID: 11844294063     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Du Vignault V, Ressler C and Tipett S: The sequence of amino-acids in oxytocin, with a proposal for the structure of oxytocin. J Biol Chem 205: 949-957, 1953.
2. Serradeil-Le Gal C, Valette G, Foulon L, Germain G, Advenier C, Naline E, Bardou M, Martinolle JP, Pouzet B, Raufaste D, Garcia C, Double-Cazanave E, Pauly M, Pascal M, Barbier A, Scatton B, Maffrand JP and Le Fur G: SSR126768A: a new selective and orally-active oxytocin receptor antagonist for the prevention of preterm labor. J Pharmacol Exp Ther 309: 414-424, 2004.
3. Nilsson L, Reinheimer T, Steinwall M and Akerlund M: FE 200 440: a selective oxytocin antagonist on the term-pregnant human uterus. BJOG 110: 1025-1028, 2003.
4. Flouret G, Chaloin O and Slaninova J: Analogues of a potent oxytocin antagonist with truncated C-terminus or shorter amino acid side chain of the basic amino acid at position 8. J Pept Sci 9: 393-401, 2003.
5. Cirillo R, Gillio Tos E, Schwarz MK, Quattropani A, Scheer A, Missotten M, Dorbais J, Nichols A, Borrelli F, Giachetti C, Golzio L, Marinelli P, Thomas RJ, Chevillard C, Laurent F, Portet K, Barberis C and Chollet A: Pharmacology of (2S,4Z)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino) -1-[(2′-methyl[1,1′-biphenyl]-4-yl carbonyl]-2-pyrrolidinecarboxamide, a new potent and selective nonpeptide antagonist of the oxytocin receptor. J Pharmacol Exp Ther 306: 253-261, 2003.
6. Rahm VA, Hallgren A, Hogberg H, Hurtig I and Odlind V: Plasma oxytocin levels in women during labor with or without epidural analgesia: a prospective study. Acta Obstet Gynecol Scand 81: 1033-1039, 2002.
7. Rezapour M, Backstrom T and Ulmsten U: Myometrial steroid concentration and oxytocin receptor density in parturient women at term. Steroids 61: 338-344, 1996.
8. Flouret G, Majewski T, Balaspiri L, Brieher W, Mahan K, Chaloin O, Wilson L Jr and Slaninova J: Antagonists of oxytocin featuring replacement with modified beta-mercaptopropionic acids at position 1. J Pept Sci 8: 314-326, 2002.
9. Wilson L Jr, Parsons MT, Ouano L and Flouret G: A new tocolytic agent: development of an oxytocin antagonist for inhibiting uterine contractions. Am J Obstet Gynecol 163: 195-202, 1990.
10. Park SH, Song CH, Pak SC, Flouret G and Wilson L Jr: The effect of oxytocin antagonist on uterus in response to exogenous oxytocin. J Korean Med Sci 15: 299-302, 2000.
11. Wilson L Jr, Parsons MT and Flouret G: Inhibition of spontaneous uterine contractions during the last trimester in pregnant baboons by an oxytocin antagonist. Am J Obstet Gynecol 163: 1875-1882, 1990.
12. Fejgin MD, Pak SC, Flouret G, Parsons MT and Wilson L Jr: Comparison of the in vivo activity of different oxytocin antagonists in the pregnant baboons. J Soc Gyn Invest 5: 251-254, 1998.
13. Pak SC, Bertoncini D, Meyer W, Scaunas D, Flouret G and Wilson L Jr: Comparison of binding affinity of oxytocin antagonist to human and rat uterine oxytocin receptors and their correlation to the rat uterine oxytocin bioassay. Biol Reprod 51: 1140-1144, 1994.
14. Fejgin MD, Pak SC, Warnell C, Flouret G, Parsons MT and Wilson L Jr: Oxytocin antagonist inhibitory effect on the rat and baboon uterus may be overcome by prostaglandins. Am J Obstet Gynecol 171: 1076-1080, 1994.
15. An TH, Song CH, Pak SC, Choi BC, Diveky L and Flouret G: Development of a radioreceptor assay for measuring an oxytocin antagonist in blood. Gynecol Obstet Invest 56: 213-217, 2003.
16. Slusarz MJ, Slusarz R, Kazmierkiewicz R, Trojnar J, Wisniewski K and Ciarkowski J: Molecular modeling of the neurohypophyseal receptor/atosiban complexes. Protein Pept Lett 10: 295-302, 2003.
17. Song CH, So GY, Pak SC, Jang CH, Choi BC, Flouret G and Mehendale R: Comparison of oxytocin and oxytocin antagonist metabolism in the plasma of pregnant humans and baboons. Gynecol Obstet Invest 54 21-25, 2002.
18. Phaneuf S, Asboth G, Carrasco MP, Linares BR, Kimura T, Harris A and Bernal AL: Desensitization of oxytocin receptors in human myometrium. Human Reprod Update 4: 625-633, 1998.
19. Husslein P and Leitich H: Some aspects on the mechanism of human labor and delivery. Eur J Obstet Gynecol Reprod Biol 59: S3-S7, 1995.
20. Romero R, Sibai BM, Sanchez-Ramos L, Valenzuela GJ, Veille JC, Tabor B, Perry KG, Varner M, Goodwin TM, Lane R, Smith J, Shangold G and Creasy GW: An oxytocin receptor antagonist (atosiban) in the treatment of preterm labor: a randomized, double-blind, placebo-controlled trial with tocolytic rescue. Am J Obstet Gynecol 182: 1173-1183, 2000.
21. Giussani DA, Jenkins SL, Mecenas CA, Owiny JR, Wentworth RA, Winter JA, Derks JB, Honnebier M and Nathanielsz PW: The oxytocin antagonist Atosiban prolongs gestation in the rhesus monkey (Abstract). J Soc Gynecol Invest 2: 265, 1995.
22. Bernal AL, Europe-Finner GN, Phaneuf S and Watson SP: Preterm labor: a pharmacological challenge. Trends Pharmacol Sci 16: 129-133, 1995.
23. Wilson L Jr and Parsons MT: Endocrinology of human gestation. In: Reproductive Endocrinology, Surgery and Technology (Adashi EY, Rock JA and Rosenwaks Z, eds). Philadelphia, Lippincott-Raven, 1996, pp 451-475.
24. Murata T, Murata E, Liu CX, Narita K, Honda K and Higuchi T: Oxytocin receptor gene expression in rat uterus: regulation by ovarian steroids. J Endocrinol 166: 45-52, 2000.