Pharmacology of (2S,4Z)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino)-1-[(2′- methyl[1,1′-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide, a new potent and selective nonpeptide antagonist of the oxytocin receptor

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 1, 2003, Pages 253-261

  Cirillo, Rocco ^a   Tos, Enrico Gillio ^a   Schwarz, Matthias K ^d   Quattropani, Anna ^d   Scheer, Alexander ^d   Missotten, Marc ^d   Dorbais, Jerôme ^d   Nichols, Anthony ^d   Borrelli, Francesco ^a   Giachetti, Claudio ^a   Golzio, Lucia ^a   Marinelli, Paolo ^a   Thomas, Russell J ^c   Chevillard, Claude ^b   Laurent, Florence ^b   Portet, Karine ^b   Barberis, Claude ^b   Chollet, Andre ^d  

^a Istituto di Ricerche Biomediche Antoine Marxer SpA   (Italy)

^b INSERM   (France)

^c EVOTEC UK LTD   (United Kingdom)

^d SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARGIPRESTOCIN; N (2 HYDROXY 2 PHENYLETHYL) 4 (METHOXYIMINO) 1 [[2' METHYL (1,1' BIPHENYL) 4 YL]CARBONYL] 2 PYRROLIDINECARBOXAMIDE; OXYTOCIN; OXYTOCIN ANTAGONIST; OXYTOCIN RECEPTOR; TRITIUM; UNCLASSIFIED DRUG; UTERUS SPASMOLYTIC AGENT;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CHINESE HAMSTER; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; FEMALE; NONHUMAN; OVARY CELL; PREMATURE LABOR; PRIORITY JOURNAL; RAT; TOCOLYSIS; UTERUS CONTRACTION;

ANESTHESIA; ANIMALS; CELLS, CULTURED; CHO CELLS; CRICETINAE; DINOPROST; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IMINES; OXYTOCIN; PREGNANCY; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, OXYTOCIN; RECEPTORS, VASOPRESSIN; UTERINE CONTRACTION;

EID: 0038340968     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.049395     Document Type: Article

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