Engineered β-cells secreting dipeptidyl peptidase IV-resistant glucagon-like peptide-1 show enhanced glucose-responsiveness

Life Sciences

Volumn 76, Issue 11, 2005, Pages 1239-1248

  Islam, Md Shahidul ^a,b,d   Rahman, Syed Atiqur ^c   Mirzaei, Zahra ^c   Islam, Khalid Bin ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Research Centre   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d STOCKHOLM SÖDER HOSPITAL   (Sweden)

Author keywords

Diabetes; Gene therapy; Insulin secretion; Pancreatic beta cells

Indexed keywords

CRE RECOMBINASE; CYCLIC AMP; DIPEPTIDYL PEPTIDASE IV; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE;

ANIMAL CELL; ARTICLE; CHINESE HAMSTER; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME RELEASE; GENE MUTATION; GENE THERAPY; GENETIC TRANSFECTION; IMMUNOREACTIVITY; INSULIN RELEASE; INSULINOMA; LUNG FIBROBLAST; MOLECULAR CLONING; NONHUMAN; PANCREAS ISLET BETA CELL; PLASMID; RAT; TUMOR CELL;

ANIMALS; ANTIGENS, CD26; CELL LINE, TUMOR; CLONE CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; GENETIC ENGINEERING; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; HUMANS; INSULIN; INSULINOMA; ISLETS OF LANGERHANS; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; RABBITS; RATS; RECEPTORS, GLUCAGON; TRANSFECTION;

CRICETINAE; CRICETULUS GRISEUS;

EID: 11844287531     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.08.021     Document Type: Article

References (22)

1. M. Asfari, D. Janjic, P. Meda, G. Li, P.A. Halban, and C.B. Wollheim Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines Endocrinology 130 1 1992 167 178
2. R. Burcelin, W. Dolci, and B. Thorens Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1 Metabolism 48 2 1999 252 258
3. R. Burcelin, E. Rolland, W. Dolci, S. Germain, V. Carrel, and B. Thorens Encapsulated, genetically engineered cells, secreting glucagon-like peptide-1 for the treatment of non-insulin-dependent diabetes mellitus Annals of the New York Academy of Sciences 875 1999 277 285
4. J. Buteau, R. Roduit, S. Susini, and M. Prentki Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells Diabetologia 42 7 1999 856 864
5. O.G. Chepurny, and G.G. Holz Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic [beta]-cell lines for use in transplantation Cell and Tissue Research 307 2 2002 191 201
6. T.D. de la, T. Halvorsen, C. Demeterco, B. Tyrberg, P. Itkin-Ansari, M. Loy, S.J. Yoo, E. Hao, S. Bossie, and F. Levine Beta-cell differentiation from a human pancreatic cell line in vitro and in vivo Molecular Endocrinology 15 3 2001 476 483
7. M.K. Gutniak, C. Orskov, J.J. Holst, B. Ahrén, and S. Efendic Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus New England Journal of Medicine 326 20 1992 1316 1322
8. J.J. Holst Enteroglucagon Annual Review of Physiology 59 1997 257 271
9. G.G. Holz, W.M. Kuhtreiber, and J.F. Habener Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37) Nature 361 6410 1993 362 365
10. H. Hui, R. Yu, C. Bousquet, and R. Perfetti Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion Endocrinology 143 9 2002 3529 3539
11. 2+ release in INS-1 pancreatic β-cells Journal of Physiology 536 Pt 2 2001 375 385
12. T. Kayo, Y. Konda, S. Tanaka, K. Takata, A. Koizumi, and T. Takeuchi Developmental expression of proprotein-processing endoprotease furin in rat pancreatic islets Endocrinology 137 11 1996 5126 5134
13. P.E. MacDonald, W. El Kholy, M.J. Riedel, A.M. Salapatek, P.E. Light, and M.B. Wheeler The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion Diabetes 51 Suppl 3 2002 S434 S442
14. E. Mannucci, A. Ognibene, F. Cremasco, G. Bardini, A. Mencucci, E. Pierazzuoli, S. Ciani, A. Fanelli, G. Messeri, and C.M. Rotella Glucagon-like peptide (GLP)-1 and leptin concentrations in obese patients with Type 2 diabetes mellitus Diabet. Med. 17 10 2000 713 719
15. K. Moens, V. Berger, J.M. Ahn, C. Van Schravendijk, V.J. Hruby, D. Pipeleers, and F. Schuit Assessment of the role of interstitial glucagon in the acute glucose secretory responsiveness of in situ pancreatic beta-cells Diabetes 51 3 2002 669 675
16. S. Mojsov, G. Heinrich, I.B. Wilson, M. Ravazzola, L. Orci, and J.F. Habener Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing J. Biol. Chem. 261 1986 11880 11889
17. L. Pala, E. Mannucci, A. Pezzatini, S. Ciani, J. Sardi, L. Raimondi, A. Ognibene, A. Cappadona, B.G. Vannelli, and C.M. Rotella Dipeptidyl peptidase-IV expression and activity in human glomerular endothelial cells Biochem. Biophys. Res. Commun. 310 1 2003 28 31
18. J. Sambrook, and D.W. Russel Molecular Cloning: A Laboratory Manual 2001 Cold Spring Haror Laboratory Press New York
19. Y. Sawada, B. Zhang, F. Okajima, T. Izumi, and T. Takeuchi PTHrP increases pancreatic beta-cell-specific functions in well-differentiated cells Mol. Cell Endocrinol. 182 2 2001 265 275
20. G. Skoglund, M.A. Hussain, and G.G. Holz Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element Diabetes 49 7 2000 1156 1164
21. C. Verdich, A. Flint, J.P. Gutzwiller, E. Naslund, C. Beglinger, P.M. Hellstrom, S.J. Long, L.M. Morgan, J.J. Holst, and A. Astrup A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans J. Clin. Endocrinol. Metab. 86 9 2001 4382 4389
22. C. Widmann, E. Burki, W. Dolci, and B. Thorens Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signaling by the endogenous receptors of beta cell lines Mol. Pharmacol. 45 5 1994 1029 1035