Magnesium deficiency induces bone loss in the rat

Mineral and Electrolyte Metabolism

Volumn 24, Issue 5, 1998, Pages 314-320

  Rude, Robert K ^a   Kirchen, Mary E ^a   Gruber, Helen E ^b   Stasky, Audrey A ^b   Meyer, Martha H ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CAROLINAS MEDICAL CENTER   (United States)

Author keywords

Magnesium; Osteoblast; Osteoclast; Osteoporosis

Indexed keywords

MAGNESIUM; MINERAL; OSTEOCALCIN; PARATHYROID HORMONE; VITAMIN D;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE ATROPHY; BONE METABOLISM; CALCIUM INTAKE; CONTROLLED STUDY; FEMALE; HYPOCALCEMIA; MAGNESIUM DEFICIENCY; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; RAT;

EID: 0031856066     PISSN: 03780392     EISSN: None     Source Type: Journal    
DOI: 10.1159/000057389     Document Type: Article

References (58)

1. Arnaud SB, Newcomer AD, Go VLW: Hypomagnesemia and vitamin D deficiency in patients with non-tropical sprue (abstract). Clin Res 1976;24:564.
2. Booth CC, Hanna S, Babouris N, MacIntrye I: Incidence of hypomagnesaemia in intestinal malabsorption. Br Med J 1963;ii:141-144.
3. Nadler JL, Malayan S, Luong H, Shaw S, Natarajan RD, Rude RK: Intracellular free magnesium deficiency plays a key role in increased platelet reactivity in type II diabetes mellitus. Diabetes Care 1992;15:835-841.
4. Ryzen E, Nelson TA, Rude RK: Low blood mononuclear cell magnesium content and hypocalcemia in normomagnesemic patients. West J Med 1987;147:549-553.
5. Ryzen E, Servi KL, DeRusso P, Kershaw A, Stephen T, Rude RK: Determination of intracellular free magnesium by nuclear magnetic resonance in human magnesium deficiency. J Am Coll Nutr 1989;8:580-587.
6. Sjogren A, Claes-Henrik F, Nilsson A: Magnesium deficiency in IDDM related to level of glycosylated hemoglobin. Diabetes 1986;35: 459-463.
7. Anast CS, Forte LF: Parathyroid function and magnesium depletion in the rat. Endocrinology 1983;113:184-189.
8. Bikle DD, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ: Bone disease in alcohol abuse. Ann Intern Med 1985; 103:42-48.
9. Crilly RG, Anderson C, Hogan D, Delaquerriere-Richardson L: Bone histomorphometry, bone mass, and related parameters in alcoholic males. Calcif Tissue Int 1988;43:269-276.
10. Hartley J: Osseous changes and fractures in the malabsorption syndrome. J M Sinai Hosp 1957;24:346.
11. Hui SL, Epstein S, Johnston CC Jr: A prospective study of bone mass in patients with type I diabetes. J Clin Endocrinol Metab 1985;60:74-80.
12. McNair P, Christiansen C, Christensen MS, Madsbad S, Faber OK, Binder C, Transbol I: Development of bone mineral loss in insulintreated diabetes: A 1 and 1/2 years follow-up study in sixty patients. Eur J Clin Invest 1981; 11:55-59.
13. Fatemi S, Ryzen E, Flores, Endres DB, Rude RK: Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. J Clin Endocrinol Metab 1991;73:1067-1072.
14. Rude RK, Oldham SB, Singer FR: Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human Mg deficiency. Clin Endocrinol 1976;5:209-224.
15. Rude RK, Adams JS, Ryzen E: Low serum concentrations of 1,25-dihydroxy-vitamin D in human magnesium deficiency. J Clin Endocrinol Metab 1985;61:933-940.
16. Rude RK, Oldham SB, Sharp CF, Singer FR: Parathyroid hormone secretion in magnesium deficiency. J Clin Endocrinol Metab 1978;47: 800-806.
17. Boskey AL, Rimnac CM, Bansal M, Federman M, Lian J, Boyan BD: Effect of short-term hypomagnesemia on the chemical and mechanical properties of rat bone. J Orthop Res 1992; 10:774-783.
18. Heroux O, Peter D, Tanner A: Effect of a chronic suboptimal intake of magnesium on magnesium and calcium content of bone and on bone strength of the rat. Can J Physiol Pharmacol 1975;53:304-310.
19. Jones JE, Schwartz R, Krook L: Calcium homeostasis and bone pathology in magnesium deficient rats. Calcif Tissue Int 1980;31:231-238.
20. Kenney MA, McCoy H, Williams L: Effects of magnesium deficiency on strength, mass and composition of rat femur. Calcif Tissue Int 1994;54:44-49.
21. McCoy H, Kenny MA, Gillham B: Effects of magnesium deficiency on composition and conformation of femur in rats of different ages. Nutr Rep Int 1979;19:233-240.
22. Hollis BW: Assay of circulating 1,25-dihydroxyvitamin D involving a novel single-cartridge extraction and purification procedure. Clin Chem 1986;32:2060.
23. Kay MA, Meyer MH, Delzer PR, Meyer RA Jr: Changing patterns of femoral and skeletal mineralization during growth in juvenile X-linked hypophosphatemic mice. Miner Electrolyte Metab 1985;11:374-380.
24. Meyer M, Meyer RA Jr: Unsuitability of porcelain crucibles for dry ashing of biological tissues for calcium analysis. Clin Chem 1976;22: 1396-1398.
25. Gruber HE, Marshall GJ, Nolasco LM, Kirchen ME, Rimoin DL: Alkaline and acid phosphate demonstration in human bone and cartilage: Effects of fixation intervals and methacrylate embedments. Stain Technol 1988;63:299-305.
26. Gruber HE: Adaptations of Goldner's-Masson trichrome stain for the study of undecalcified plastic-embedded bone. Biotech Histochem 1992;67:30-34.
27. Parfitt AM, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR: Bone histomorphometry nomenclature, symbols and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987;2:595-610.
28. Mirra JM, Alcock NW, Shils ME, Tannenbaum P: Effects of calcium and magnesium deficiencies on rat skeletal development and parathyroid gland area. Magnesium 1982;1: 16-33.
29. Molteni N, Caraceni MP, Bardella MT, Ortolani S, Gandolini GG, Bianchi P: Bone mineral density in adult celiac patients and the effect of gluten-free diet from childhood. Am J Gastroenterol 1990;85:51-53.
30. Bouillon R: Diabetic bone disease. Calcif Tissue Int 1991;49:155-160.
31. Goodman WG, Hori MT: Diminished bone formation in experimental diabetes. Diabetes 1984;33:825-831.
32. Ishida H, Seino Y, Taminato T, Usami M, Takeshita N, Seino Y, Tsutsumi C, Moriuchi S, Akiyama Y, Hara K, Imura H: Circulating levels and bone contents of bone-carboxyglutamic acid-containing protein are decreased in streptozocin-induced diabetes. Diabetes 1988;37: 702-706.
33. Rico H, Hernandez ER, Cabranes JA, Gomez-Castresana F: Suggestion of a deficient osteoblastic function in diabetes mellitus: The possible cause of osteopenia in diabetics. Calcif Tissue Int 1989;45:71-73.
34. Verhaeghe J, SuikerAMH, Nyomba BL, Visser WJ, Einhorn TA, DeQueker J, Bouillon R: Bone mineral homeostasis in spontaneously diabetic BB rats. II. Impaired bone turnover anddecreased osteocalcin synthesis. Endocrinology 1989;124:573-582.
35. Peris P, Pares A, Guanabens N, Pons F, De Osaba MJM, Caballeria J, Rodes J, Muñoz-Gomez J: Reduced spinal and femoral bone mass and deranged bone mineral metabolism in chronic alcoholics. Alcohol Alcohol 1992;27: 619-625.
36. Rico H, Cabranes JA, Cabello J, Gomez-Castresana F, Hernandez ER: Low serum osteocalcin in acute alcohol intoxication. Bone Miner 1987;2:221-225.
37. Cohen L, Laor A, Kitzes R: Lymphocyte and bone magnesium in alcohol-associated osteoporosis. Magnesium 1985;4:148-152.
38. Carpenter TO, Mackowiak SJ, Troiano N, Gundberg CM: Osteocalcin and its message: Relationship to bone histology in Mg-deprived rats. Am J Physiol 1992;26:E107-E114.
39. Gruber HE, Massry SG, Brautbar N: Effect of relatively long-term hypomagnesemia on the chondro-osseous features of the rat vertebrae. Miner Electrolyte Metab 1994;20:282-286.
40. Shils ME: Magnesium deficiency and calcium and parathyroid hormone interrelations; in Prasad AS (ed): Trace Elements in Human Health and Disease. New York, Academic Press, 1976, pp 23-46.
41. 3. Magnes Res 1992;5:5-14.
42. 3; in Norman AW, Schaefer K, Grigoleit HG, Herrath DV (eds): Vitamin D Molecular, Cellular and Clinical Endocrinology. Berlin, de Gruyter, 1988, pp 624-625.
43. Reeve J: PTH: A future role in the management of osteoporosis: J Bone Miner Res 1996; 11:440-445.
44. Nyomba BL, Bouillon R, Bidingija M, Kandjingu K, DeMoor P: Vitamin D metabolites and their binding protein in adult diabetic patients. Diabetes 1986;35:91-95.
45. Saggese G, Bertelloni S, Baroncelli GI, Federico G, Calisti I, Fusaro C: Bone demineralization and impaired mineral metabolism in insulin-dependent diabetes mellitus. Helv Paediatr Acta 1988;43:405-414.
46. Marier JR: Magnesium content of the food supply in the modern day world. Magnesium 1986; 5:1-8.
47. Stendig-Lindberg G, Tepper R, Leichter I: Trabecular bone density in a two-year controlled trial or peroral magnesium in osteoporosis. Magnes Res 1993;6:155-163.
48. Tucker K, Kiel DP, Hannan MT, Felson DT: Magnesium intake is associated with bone mineral density in elderly women. J Bone Miner Res 1995;10(suppl):466.
49. Angus RM, Sambrook PN, Pockock NA, Eisman JA: Dietary intake and bone mineral density. Bone Miner 1988;4:265-277.
50. Freudenheim JL, Johnson NE, Smith EL: Relationships between usual nutrient intake and bone mineral content of women 35-65 years of age: Longitudinal and cross-sectional analysis. Am J Clin Nutr 1986;44:863-876.
51. Yano K, Heilbrun LK, Wasnich RD, Hankin JH, Vogel JM: The relationship between diet and bone mineral content of multiple skeletal sites in elderly women living in Hawaii. Am J Clin Nutr 1985;42:877-888.
52. Cohen L, Kitzes R: Infrared spectroscopy and magnesium content of bone mineral in osteoporotic women. Isr J Med Sci 1981;17:1123-1125.
53. Cohen L: Recent data on magnesium and osteoporosis. Magnes Res 1988;1:85-87.
54. Reginster JY, Strause L, Deroisy R, Lecart MP, Saltman P, Franchimont P: Preliminary report of decreased serum magnesium in postmenopausal osteoporosis. Magnesium 1989;8:106-109.
55. Wallach S: Effects of magnesium on skeletal metabolism. Magnes Trace Elem 1990;9:1-14.
56. Wallack S: Relation of magnesium to osteoporosis and calcium urolithiasis. Magnes Trace Elem 1991;10:281-286.
57. Abraham GE, Grewal H: A total dietary program emphasizing magnesium instead of calcium. J Reprod Med 1990;35:503-507.
58. Rude RK, Olerich M: Magnesium deficiency: Possible role in osteoporosis associated with gluten sensitive enteropathy. Osteoporos Int 1996;6:453-461.