Nausea and vomiting of pregnancy: An evidence-based review

Journal of Perinatal and Neonatal Nursing

Volumn 18, Issue 4, 2004, Pages 312-328

  Davis, Mitzi ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Nausea and vomiting of pregnancy; Nursing care; Pregnancy; Stress

Indexed keywords

BENDECTIN; CANNABIS; CORTICOSTEROID; DIMENHYDRINATE; DIPHENHYDRAMINE; DOPAMINE RECEPTOR BLOCKING AGENT; DOXYLAMINE; GINGER EXTRACT; HISTAMINE H1 RECEPTOR ANTAGONIST; METOCLOPRAMIDE; MULTIVITAMIN; ONDANSETRON; PYRIDOXINE; SEROTONIN AGONIST; VITAMIN;

ACUPUNCTURE; AVERSION; CLINICAL FEATURE; DIET; DISEASE ASSOCIATION; EVIDENCE BASED MEDICINE; GINGER; HUMAN; MATERNAL MORTALITY; MENSTRUAL CYCLE; NAUSEA; NURSING; PATHOPHYSIOLOGY; PREGNANCY; REVIEW; RISK FACTOR; SALIVATION; SLEEP DISORDER; SMOKING; STOMACH DISEASE; STRESS; TREATMENT OUTCOME; VOMITING;

EID: 11844268069     PISSN: 08932190     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005237-200410000-00002     Document Type: Review

References (91)

1. Lacroix R, Eason E, Melzack R. Nausea and vomiting during pregnancy: a prospective study of its frequency, intensity and patterns of change. Am J Obstet Gynecol. 2000;183:931-937.
2. Gadsby R, Barnie-Adshead A, Jagger C. A prospective study of nausea and vomiting during pregnancy. Br J Gen Pract. 1993;43:245-248.
3. Rhodes P. A medical appraisal of the Brontes. Bronte Soc Trans. 1972;16:101-109.
4. Gazmararian J, Peterson R, Jamieson D, et al. Hospitalization during pregnancy among managed care enrollees. Obstet Gynecol. 2002;100:94-100.
5. Koren G, Boskovic R, Hard M, Maltepe C, Navioz Y, Einarson A. Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system for nausea and vomiting of pregnancy. Am J Obstet Gynecol. 2002;186:S228-S231.
6. Tareen A, Baseer A, Jaffry M, Shafiq M. Thyroid hormone in hyperemesis gravidarum. J Obstet Gynecol. 1995;21:497-501.
7. Irving F. The treatment of pernicious vomiting of pregnancy. Va Med Mon. 1940;67:717-724.
8. Weigel R, Weigel M. Nausea and vomiting of early pregnancy and pregnancy outcome. A meta-analytical review. Br J Obstet Gynecol. 1989;96:1312-1318.
9. Flaxman S, Sherman P. Morning sickness: a mechanism for protecting mother and embryo. Q Rev Bio. 2000;75:113-148.
10. Minturn L, Weiher A. The influence of diet on morning sickness: a cross-culture study. Med Anthropol. 1984;8:71-75.
11. Huxley R. Nausea and vomiting in early pregnancy: its role in placental development. Obstet Gynecol. 2000;95:779-782.
12. American College of Obstetricians and Gynecologists. ACOG practice bulletin. Clinical management guidelines for obstetrician-gynecologists: nausea and vomiting of pregnancy. Obstet Gynecol. 2004;103:803-811.
13. Hallak M, Tsalamandris K, Dombrowski M, Isada N, Pryde P, Eva M. Hyperemesis gravidarum: effects on fetal outcome. J Reprod Med. 1996;41:871-874.
14. Czeizel A, Sarkozi A, Wyszynski D. Protective effect of hyperemesis gravidarum for nonsyndromic oral clefts. Obstet Gynecol. 2003;101:737-744.
15. Klebanoff M, Mills J. Is vomiting during pregnancy teratogenic? BMJ. 1986;292:724-726.
16. Miller F. Nausea and vomiting in pregnancy: the problem of perception - is it really a disease? Am J Obstet Gynecol. 2002;186:S182-S183.
17. Vallacott I, Cooke E, James C. Nausea and vomiting in early pregnancy. Int J Gynaecol Obstet. 1988;27:7-62.
18. Goodwin T. Nausea and vomiting of pregnancy: an obstetric syndrome. Am J Obstet Gynecol. 2002;186:S184-S189.
19. Mazzotta R, Stewart D, Koren G, Magee L. Factors associated with elective termination of pregnancy among Canadian and American women with nausea and vomiting of pregnancy. J Psychosom Obstet Gynaecol. 2001;22:7-12.
20. Attard C, Kohli M, Coleman S, et al. The burden of illness of severe nausea and vomiting of pregnancy in the United States. Am J Obstet Gynecol. 2002;186:S220-S227.
21. O'Brien B, Relyea J, Lidstone T. Diary reports of nausea and vomiting during pregnancy. Clin Nurs Res. 1997;6:239-252.
22. O'Brien B, Evans M, White-McDonald E. Isolation from "being alive": coping with severe nausea and vomiting of pregnancy. Nurs Res. 2002;51:302-308.
23. Whitehead S, Holden W, Andrews P. Pregnancy sickness. In: Branchi A, Grelot I, Miller A, King G, eds. Mechanisms and Control of Emesis. Vol 223. Montrouge, France: J Libbey Eurotext;1992:297-306.
24. Cited in Block F. Maternal susceptibility to nausea and vomiting of pregnancy: is the vestibular system involved? Am J Obstet Gynecol. 2002;186:S204-S209.
25. Heinrichs L. Linking olfaction with nausea and vomiting of pregnancy, recurrent abortion, hyperemesis gravidarum and migraine headache. Am J Obstet Gynecol. 2002;186:S215-S219.
26. Signorello L, Harlow B, Wang S, Erick M. Saturated fat intake and the risk of severe morning sickness. Epidemiology. 1998;9:636-640.
27. Kallen B. Hyperemesis gravidarum during pregnancy and delivery outcome: a registry study. In: Koren G, Bishai R, eds. Nausea and Vomiting of Pregnancy: State of the Art 2000. Proceedings of the First International Conference on Nausea and Vomiting of Pregnancy. Toronto, Canada: Motherisk. Available at: http://www.nvp-volumes.org/index.htm. Accessed June 15, 2004.
28. Askling J, Erlandsson G, Kaijser M, Akre O, Ekbom A. Sickness in pregnancy and sex of child. Lancet. 1999;354:2053.
29. Schiff M, Reed S, Daling J. The sex ratio of pregnancies complicated by hospitalisation for hyperemesis gravidarum. BJOG Int J Obstet Gynecol. 2004;111:27-30.
30. O'Brien B, Zhou Q. Variables related to nausea and vomiting during pregnancy. Birth. 1995;22:93-100.
31. Kallen B, Lundberg G, Aberg A. Relationship between vitamin use, smoking, and nausea and vomiting of pregnancy. Acta Obstet Gynecol Scand. 2003;82:916-920.
32. Gadsby R, Barnie-Adshead A, Jagger C. Pregnancy nausea related to women's obstetric and personal histories. Gynecol Obstet Invest. 1997;43:108-111.
33. Jarnfelt-Samisoe A, Erikson B, Leissner K, Samsioe G. Gallbladder disease related to use of oral contraceptives and nausea in pregnancy. South Med J. 1985;78:1040-1044.
34. Samsioe G, Crona N, Enk L, Jarnfelt-Samsioe A. Does position and size of corpus luteum have any effect on nausea of pregnancy? Acta Obstet Gynecol Scand. 1986;65:427-429.
35. Lundberg K, Aberg A. Relationship between vitamin use, smoking, and nausea and vomiting of pregnancy. Acta Obstet Gynecol Scand. 2003;82:916-920.
36. Emelianova S, Mazzotta P, Einarson A, Koren G. Prevalence and severity of nausea and vomiting of pregnancy and effect of vitamin supplementation. Clin Invest Med. 1999;22:106-110.
37. Beatie W, Buckley D, Forrest J. The incidence of postoperative nausea and vomiting in women undergoing laparoscopy is influenced by the day of menstrual cycle. Can J Anaesth. 1991;38:298-302.
38. Corey L, Berg K, Solaas M, Nance W. The epidemiology of pregnancy complications and outcome in a Norwegian twin population. Obstet Gynecol. 1992;80:989-994.
39. Koch K, Stern R, Vasey M, Botti J, Creasy G, Dwyer A. Gastric dysrhythmias and nausea of pregnancy. Dig Dis Sci. 1990;35:961-968.
40. Walsh J, Hasler W, Nugent C, Owyang C. Progesterone and estrogen are potential mediators of gastric slow wave dysrhythmias in nausea of pregnancy. Am J Physiol. 1996;270:506-514.
41. Maes B, Spitz B, Ghoos Y, Hiele M, Evenepoel P, Rutgeerts P. Gastric emptying in hyperemesis and non-dyspeptic pregnancy. Aliment Pharmacol Ther. 1999;13:237-243.
42. Hayakawa S, Najajima S, Karasaki-Suzuki M, et al. Frequent presence of Helicobacter pylori genome in the saliva of patients with hyperemesis gravidarum. Am J Perinatol. 2000;17:243-247.
43. Shirin H, Sadan O, Shevah O, et al. Positive serology for Helicobacter pylori and vomiting in pregnancy. Arch Gynecol Obstet. 2004;270:10-14.
44. Weyermann M, Brenner H, Adler G, et al. Helicobacter pylori infection and the occurrence and severity of gastrointestinal symptoms during pregnancy. Am J Obstet Gynecol. 2003;189:526-531.
45. Kuscu N, Koyuncu F. Hyperemesis gravidarum: current concepts and management. Postgrad Med J. 2002;78:76-79.
46. Buckwalter J, Simpson S. Psychological factors in the etiology and treatment of severe nausea and vomiting in pregnancy. Am J Obstet Gynecol. 2002;186:S210-S214.
47. Dooley L. Psychoanalysis of Charlotte Bronte as a type of the woman of genius. Am J Psychol. 1920;31:22.
48. Simpson S, Goodwin T, Robins S, et al. Psychological factors and hyperemesis gravidarum. J Womens Health Gend Based Med. 2001;1:471-477.
49. Bogen J. Neurosis: a mis-diagnosis. Perspect Biol Med. 1994;37:263-274.
50. Chou F, Lin L, Cooney A, Walker L, Riggs M. Psychosocial factors related to nausea, vomiting, and fatigue in early pregnancy. J Nurs Scholarsh. 2003;35:119-125.
51. Iatrakis G, Sakellaropoulos G, Kourkoubas A, Kabounia S. Vomiting and nausea in the first 12 weeks of pregnancy. Psychother Psychosom. 1998; 49:22-24.
52. Wolkind S, Zajicek E. Psycho-social correlates of nausea and vomiting of pregnancy. J Psychosom Res. 1978;22:1-5.
53. Apfel R, Kelly S, Frankel F. The role of hypnotizability in the pathogenesis and treatment of nausea and vomiting of pregnancy. J Psychosom Obstet Gynaecol. 1986;5:179-186.
54. Herxheimer A. Drugs and other treatments to prevent and control nausea and vomiting in early pregnancy: trial reports published since 1950. In: Koren G, Bishai R, eds. Nausea and Vomiting of Pregnancy: State of the Art 2000. Proceedings of the First International Conference on the Nausea and Vomiting of Pregnancy. Toronto, Canada: Motherisk; 20-24. Available at: http://www.nvp- volumes.org/index.htm. Accessed June 16, 2004.
55. Koren G, Levichek Z. The teratogenicity of drugs for nausea and vomiting of pregnancy: perceived versus true risk. Am J Obstet Gynecol. 2002;186:S248-S252.
56. Flake Z, Scalley R, Bailey A. Practical selection of antiemetics. Am Acad Fam Physicians. 2004;69:1149-1176.
57. Lamm S. Epidemiological assessment of the safety and efficacy of Bendectin. In: Koren G, Bishai R, eds. Nausea and Vomiting of Pregnancy: State of the Art 2000. Proceedings of the First International Conference on Nausea and Vomiting of Pregnancy. Toronto, Canada: Motherisk. Available at: http://www.nvp volumes.org/index.htm. Accessed June 15, 2004.
58. Seto A, Einarson T, Koren G. Pregnancy outcome following first trimester exposure to anti-histamines: meta-analysis. Am J Perinatol. 1997;14:119-124.
59. Mazotta P, Magee L. A risk-benefit assessment of pharmacological and nonpharmacological treatment for nausea and vomiting of pregnancy. Drugs. 2000;59:781-800.
60. Boneva R, Moore C, Botto L, Wong L, Erickson J. Nausea during pregnancy and congenital heart defects: a population-based case control study. Am J Epid. 1999;149:717-725.
61. Magee L, Mazzotta P, Koren G. Evidence-based view of safety and effectiveness of pharmacologic therapy for nausea and vomiting of pregnancy (NVP). Am J Obstet Gynecol. 2002;186:S256-S261.
62. Sorensen H, Nielsen G, Christensen K, Tage-Jensen U, Ekbom A, Baron J. Birth outcome following maternal use of metroclopramide: the Euromap study group. Br J Clin Pharmacol. 2000;49:264-268.
63. Berkovitch M, Mazzota P, Greenberg R, et al. Metroclopramide for nausea and vomiting of pregnancy: a prospective multicenter international study. Am J Perinatol. 2002;19:311-316.
64. Ziaei S, Hosseiney F, Faghihzadeh S. The efficacy of low dose of prednisolone in the treatment of hyperemesis gravidarum. Acta Obstet Gynecol Scand. 2004;83:272-275.
65. Safari H, Fassett M, Souter I, Alsulymane O, Goodwin T. The efficacy of methylprednisonone in the treatment of hyperemesis gravidarum: a randomized, double-blind, controlled study. Am J Obstet Gynecol. 1998;179:921-924.
66. Yost N, McIntire D, Wians F, Ramin S, Balko J, Leveno K. A randomized, placebo-controlled trial of corticosteroids for hyperemesis due to pregnancy. Obstet Gynecol. 2003;102:1250-1254.
67. Park-Wyllie L, Mazzotta P, Pastuszak A, et al. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology. 2000;62:385-392.
68. Niebyl J, Goodwin T. Overview of nausea and vomiting of pregnancy with an emphasis on vitamins and ginger. Am J Obstet Gynecol. 2002;186:S253-S255.
69. 12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998.
70. US Pharmacopeia Dietary Supplement Verification Program. 2002-2004. Available at: http://www.uspverified.org. Accessed June 23, 2004.
71. Block F. Maternal susceptibility to nausea and vomiting of pregnancy: is the vestibular system involved? Am J Obstet Gynecol. 2002;186:S204-S209.
72. Mahady G, Pendland S, Yun G, Lu Z, Stoia A. Ginger (Zingiber officinale) and the gingerols inhibits the growth of CagA+ strains of Helicobacter pylori. Anticancer Res. 2003;23:3699-3702.
73. Fischer-Rasmussen W, Kjaer S, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol. 1991;38:19-24.
74. Portnoi G, Chng L, Karimi-Tabesh L, Koren G, Tan M, Einarson A. A prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. Am J Obstet Gynecol. 2003;189:1374-1377.
75. Backon J. Ginger in preventing nausea and vomiting of pregnancy: a caveat due to its thromboxane synthetase activity and effect on testosterone binding [letter]. Eur J Obstet Gynecol Reprod Biol. 1991;42:163-164.
76. Singer L, Salvator A, Arendt R, Minnes S, Farkas K, Kliegman R. Effect of cocaine/polydrug exposure and maternal psychological distress on infant birth outcomes. Neurotoxicol Teratol. 2002;24:127-135.
77. Smith C, Crowther C, Beilby J. Acupuncture to treat nausea and vomiting in early pregnancy: a randomized controlled trial. Birth. 2002;29:1-9.
78. Roscoe J, Matteson S. Acupressure and acustimulation bands for control of nausea: a brief review. Am J Obstet Gynecol. 2002;186:S244-S247.
79. Rosen T, Veciana M, Miller H, Stewart L, Rebarber A, Slotnick R. A randomized controlled trial of nerve stimulation for relief of nausea and vomiting in pregnancy. Obstet Gynecol. 2003;102:129-135.
80. Czeizel A. Prevention of hyperemesis is better than treatment. Am J Obstet Gynecol. 1996;174:1667.
81. Chandra K, Magee L, Einarson A, Koren G. Nausea and vomiting in pregnancy: results of a survey that identified interventions used by women to alleviate their symptoms. J Psychosom Obstet Gynaecol. 2003;24:71-75.
82. Jadek M, Shadigian E, Kim M, et al. Protein meals reduce nausea and gastric slow wave dysrhythmic activity in first trimester pregnancy. Am J Physiol. 1999;277:G855-G861.
83. Lamar M, Kuehl T, Cooney A, Gayle L, Holleman S, Allen S. Jelly beans as an alternative to a fifty-gram glucose beverage for gestational diabetes screening. Am J Obstet Gynecol. 1999;181:1154-1157.
84. Barbour L, Friedman J. Management of diabetes in pregnancy. In: Goldfine I, Rushakoff R, eds. Diabetes and Carbohydrate Metabolism. 2003. Available at: http:/www.endotext.org/diabetes/index.htm. Accessed June 3, 2004.
85. Jokest M, Gatto M, Fazio R, Stern R, Koch K. Slow deep breathing prevents the development of tachygastria and symptoms of motion sickness. Aviat Space Environ Med. 1999;70:1189-1192.
86. Tsui B, Dennehy C, Tsourounis C. A survey of dietary supplement use during pregnancy at an academic medical center. Am J Obstet Gynecol. 2001;185:433-437.
87. Boyd K, Ross E, Sherman S. Jelly beans as an alternative to a cola beverage containing fifty grams of glucose. Am J Obstet Gynecol. 1995;173:1889-1892.
88. Mazzotta P, Magee L, Maltepe C, Lifshitz A, Navioz Y, Koren G. The perception of teratogenic risk by women with nausea and vomiting of pregnancy. Reprod Toxicol. 1999;13:313-319.
89. Teratology Society Public Affairs Committee. FDA classification of drugs for teratogenic risk. Teratology. 1994;49:406-407. Available at: http://www.teratology.org. Accessed June 19, 2004.
90. O'Brien B, Naber S. Nausea and vomiting during pregnancy: effects on the quality of women's lives. Birth. 1992;19:138-143.
91. Mazzotta R, Stewart D, Koren G, Magee L. Factors associated with elective termination of pregnancy among Canadian and American women with nausea and vomiting of pregnancy. J Psychosom Obstet Gynaecol. 2001;22:7-12.