Effect of inosine on pancreatitis: A powerful tool?

Journal of Gastroenterology

Volumn 39, Issue 1, 2004, Pages 94-95

  Takeyama, Yoshifumi ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; INOSINE; KF 24345;

ANTIINFLAMMATORY ACTIVITY; DISEASE SEVERITY; DRUG MECHANISM; EDITORIAL; IN VIVO STUDY; INTESTINE MUCOSA PERMEABILITY; MOUSE; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SEPTIC SHOCK;

ACUTE DISEASE; ANIMALS; INOSINE; MICE; PANCREATITIS; RATS;

EID: 1142287461     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00535-004-1257-5     Document Type: Editorial

References (12)

1. Yamagiwa T, Shimosegawa T, Satoh A, Kimura K, Sakai Y, Masamune A. Inosine alleviates rat caerulein pancreatitis and pancreatitis-associated lung injury. J Gastroenterol 2004;39:41-9.
2. Ralevic V, Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 1998;50:413-92.
3. Macallum GE, Walker RM, Barsoum NJ, Smith GS. Preclinical toxicity studies of an adenosine agonist, N-(2,2-diphenylethyl) adenosine. Toxicology 1991;68:21-35.
4. Satoh A, Shimosegawa T, Satoh K, Ito H, Kohno Y, Masamune A, et al. Activation of adenosine A1-receptor pathway induces edema formation in the pancreas of rats. Gastroenterology 2000;119:829-36.
5. Satoh A, Satoh K, Masamune A, Yamagiwa T, Shimosegawa T. Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis. Pancreas 2002;24:75-82.
6. Noji T, Nan-ya K, Katagiri C, Mizutani M, Sano J, Nishikawa S, et al. Adenosine uptake inhibition ameliorates cerulein-induced acute pancreatitis in mice. Pancreas 2002;25:387-92.
7. Noji T, Nan-ya K, Mizutani M, Katagiri C, Sano J, Takada C, et al. KF24345, an adenosine uptake inhibitor, ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice. Eur J Pharmacol 2002;454:85-93.
8. Marton A, Pacher P, Murthy KG, Nemeth ZH, Hasko G, Szabo C. Anti-inflammatory effects of inosine in human monocytes, neutrophils and epithelial cells in vitro. Int J Mol Med 2001;8:617-21.
9. Hasko G, Kuhel DG, Nemeth ZH, Mabley JG, Stachlewitz RF, Virag L, et al. Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock. J Immunol 2000;164:1013-9.
10. Garcia Soriano F, Liaudet L, Marton A, Hasko G, Batista Lorigados C, Deitch EA, et al. Inosine improves gut permeability and vascular reactivity in endotoxic shock. Crit Care Med 2001;29: 703-8.
11. Liaudet L, Mabley JG, Pacher P, Virag L, Soriano FG, Marton A, et al. Inosine exerts a broad range of antiinflammatory effects in a murine model of acute lung injury. Ann Surg 2002:235:568-78.
12. Liaudet L, Mabley JG, Soriano FG, Pacher P, Marton A, Hasko G, et al. Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture. Am J Respir Crit Care Med 2001;164:1213-20.