Anti-cancer and pro-apoptotic effects of an herbal medicine and Saccharomyces cerevisiae product (CKBM) on human hepatocellular carcinoma HepG2 cells in vitro and in vivo

Immunopharmacology and Immunotoxicology

Volumn 26, Issue 4, 2004, Pages 597-609

  Chan, J Y W ^a   Cheung, J Y N ^a   Luk, S C W ^b   Wu, Y J ^b   Pang, S F ^b   Fung, K P ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CK Life Sciences Int'l Holdings Inc   (Hong Kong)

Author keywords

Apoptosis; CKBM; Hepatocellular carcinoma; HepG2

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATINE KINASE; HERBACEOUS AGENT; LACTATE DEHYDROGENASE; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FLOW CYTOMETRY; HERBAL MEDICINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUGS, CHINESE HERBAL; FIBROBLASTS; G1 PHASE; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PLANTS, MEDICINAL; SACCHAROMYCES CEREVISIAE;

ANIMALIA; MUS MUSCULUS; SACCHAROMYCES CEREVISIAE;

EID: 11344291751     PISSN: 08923973     EISSN: None     Source Type: Journal    
DOI: 10.1081/IPH-200042357     Document Type: Article

References (14)

1. Guan, D.; Fang, Z. Advances in TCM treatment of primary hepatocarcinoma. J. Trad. Chin. Med. 2000, 20, 223-226.
2. Lin, S.Y.; Liu, J.D.; Chang, H.C.; Yeh, S.D.; Lin, C.H.; Lee, W.S. Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis. J. Cell. Biochem. 2002, 84, 532-544.
3. Wu, W.Y.; Xu, Q.; Shi, L.C.; Zhang, W.B. Inhibitory effects of Curcuma aromatica oil on proliferation of hepatoma in mice. World J. Gastroenterol. 2000, 6, 216-219.
4. Chih, H.W.; Chiu, H.F.; Tang, K.S.; Chang, F.R.; Wu, Y.C. Bullatacin, a potent antitumor annonaceous acetogenin, inhibits proliferation of human hepatocarcinoma cell line 2.2.15 by apoptosis induction. Life Sci. 2001, 69, 1321-1635.
5. Ahammadsahib, K.I.; Hollingworth, R.M.; McGovren, J.P.; Hui, Y.H.; McLaughlin, J.L. Mode of action of bullatacin: a potent antitumor and pesticidal annonaceous acetogenin. Life Sci. 2000, 67, 2117-2123.
6. Li, X.R.; Zhang, D.; Qi, Y.F. Experimental study on xiaoliu pingyi mixture with medicated serum in inducing apoptosis of human hepatocellular carcinoma cell line H-7402. Zhongguo Zhong Xi Yi Jie He Za Zhi 2001, 21, 684-687.
7. Guan, D.; Fang, Z.; Lu, H.; Li, H. Preliminary investigation on regulating effects of different TCM treatments on transcription of the correlated genes of liver cancer in rats. J. Trad. Chin. Med. 2003, 23, 62-66.
8. Llovet, J.M.; Burroughs, A.; Bruix, J. Hepatocellular carcinoma. Lancet 2003, 362, 1907-1917.
9. Xu, K.; Li, Z.; Zhu, D. The effect of gan fu le in interventional treatment of hepatocarcinoma. J. Trad. Chin. Med. 2000, 20, 185-186.
10. Chan, B.; Yuen, W.; Lee, W.; Wong, S.; Chung, T.; Wu, Y.; Pang, S. Immunomodulating effects of CKBM on the cytokine production in peripheral blood mononuclear cells (PBMCs) from healthy volunteers. Immunopharmacol. Immunotoxicol. 2004, 26, 177-192.
11. Wyllie, A.H.; Kerr, J.F.; Currie, A.R. Cell death: the significance of apoptosis. Int. Rev. Cytol. 1980, 68, 251-306.
12. Zhao, R.; Gish, K.; Murphy, M.; Yin, Y.; Notterman, D.; Hoffman, W.H.; Tom, E.; Mack, D.H.; Levine, A.J. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev. 2000, 15, 981-993.
13. Kluck, R.M.; Bossy-Wetzel, E.; Green, D.R.; Newmeyer, D.D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Sciences 1997, 275, 1132-1136.
14. Sivam, G.P.; Martin, P.J.; Reisfeld, R.A.; Mueller, B.M. Therapeutic efficacy of a doxorubicin immunoconjugate in a preclinical model of spontaneous metastatic human melanoma. Cancer Res. 1995, 55, 2352-2360.