Discriminative stimulus effects of ethanol in rats using a three-choice ethanol-midazolam-water discrimination

Behavioural Pharmacology

Volumn 15, Issue 8, 2004, Pages 555-567

  Porcu, P ^a   Grant, K A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

5 HT1B agonists; Alcohol; Drug discrimination; Ethanol; GABAA positive modulators; Midazolam; NMDA antagonists; Rat

Indexed keywords

1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; 2 PROPANOL; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 (4 METHYL 1 PIPERAZINYL) 7 TRIFLUOROMETHYLPYRROLO[1,2 A]QUINOXALINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 5 METHOXY 3 (1,2,3,6 TETRAHYDRO 4 PYRIDYL) 1H INDOLE; ALCOHOL; DIAZEPAM; DIZOCILPINE; MIDAZOLAM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PENTOBARBITAL; PHENCYCLIDINE; SEROTONIN 1B AGONIST; SEROTONIN 1B RECEPTOR; SODIUM CHLORIDE; WATER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR MODIFICATION; BEHAVIOR THERAPY; CONTROLLED STUDY; DECISION MAKING; DISCRIMINATION LEARNING; DISCRIMINATIVE STIMULUS; DOSE RESPONSE; DRUG DISCRIMINATION; DRUG EFFECT; DRUG SUBSTITUTION; MALE; NONHUMAN; RAT; REINFORCEMENT; STIMULUS RESPONSE; TASK PERFORMANCE;

ANIMALS; ANTI-ANXIETY AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISCRIMINATION (PSYCHOLOGY); DISCRIMINATION LEARNING; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; EXCITATORY AMINO ACID ANTAGONISTS; HYPNOTICS AND SEDATIVES; INDOLES; MIDAZOLAM; PENTOBARBITAL; PHENCYCLIDINE; PIPERAZINES; PREGNANOLONE; QUINOXALINES; RATS; RATS, LONG-EVANS; RECEPTOR, SEROTONIN, 5-HT1B; SEROTONIN AGONISTS;

EID: 11344290601     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-200412000-00004     Document Type: Article

References (54)

1. Ator NA (1990). Drug discrimination and drug stimulus generalization with anxiolytics. Drug Dev Res 20:189-204.
2. Ator NA (1999). High-dose discrimination training with midazolam: context determines generalization profile. Pharmacol Biochem Behav 64:237-243.
3. Ator NA, Grant KA, Purdy RH, Paul SM, Griffiths RR (1993). Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur J Pharmacol 241:237-243.
4. Ault DT, Werling LL (1999). Phencyclidine and dizocilpine modulate dopamine release from rat nucleus accumbens via sigma receptors. Eur J Pharmacol 386:145-153.
5. Barry H III (1991). Distinctive discriminative stimulus effects of ethanol. In: Glennon RA, Jarbe TUC, Frankenheim J III (editors): Drug Discrimination: Applications to Drug Abuse Research, NIDA Monograph 116. Washington: US Government Printing Office; pp. 131-144.
6. Barry H III, Krimmer EC (1977). Discriminable stimuli produced by alcohol and other CNS depressants. In: Lal H (editor): Discriminative Stimulus Properties of Drugs. New York: Plenum Press; pp. 73-92.
7. Bowen CA, Grant KA (1998). Pharmacological analysis of the heterogeneous discriminative stimulus effects of ethanol in rats using an ethanol-dizocilpine- water discrimination. Psychopharmacology (Berl) 139:86-94.
8. Bowen CA, Grant KA (1999). Increased specificity of ethanol's discriminative stimulus effects in an ethanol-pentobarbital-water discrimination in rats. Drug Alcohol Depend 55:13-24.
9. Bowen CA, Gatto GJ, Grant KA (1997). Assessment of the multiple discriminative stimulus effects of ethanol using an ethanol-pentobarbital-water discrimination in rats. Behav Pharmacol 8:339-352.
10. Colpaert FC (1986). Drug discrimination: behavioral, pharmacological and molecular mechanisms of discriminative drug effects. In: Goldberg SR, Stolerman IP (editors): Behavioral Analysis of Drug Dependence. New York: Academic Press; pp. 161-193.
11. Deitrich RA, Dunwiddie TV, Harris RA, Erwin VG (1989). Mechanism of action of ethanol: initial central nervous system actions. Pharmacol Rev 41:489-537.
12. De Vry J, Slangen JL (1986). Effects of training dose on discrimination and cross-generalization of chlordiazepoxide, pentobarbital and ethanol in the rat. Psychopharmacology (Berl) 88:341-345.
13. Engel SR, Purdy RH, Grant KA (2001). Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone. J Pharmacol Exp Ther 297:489-495.
14. Garcha HS, Rose IC, Stolerman IP (1985). Midazolam cue in rats: generalization tests with anxiolytic and other drugs. Psychopharmacology (Berl) 87: 233-237.
15. Gatto GJ, Bowen CA, Grant KA (1995). Assessment of the mixed discriminative stimulus effects of ethanol in a three-choice ethanol-dizocilpine-water discrimination in rats. Behav Pharmacol 6:601-613.
16. Grant KA (1994). Emerging neurochemical concepts in the actions of ethanol at ligand-gated ion channels. Behav Pharmacol 5:383-404.
17. Grant KA (1999). Strategies for understanding the pharmacological effects of ethanol with drug discrimination procedures. Pharmacol Biochem Behav 64:261-267.
18. Grant KA, Colombo G (1992). Discriminative stimulus effects of ethanol: effect of training dose on the substitution of N-methyl-D-aspartate antagonists. J Pharmacol Exp Ther 264:1241-1247.
19. Grant KA, Colombo G (1993a). Pharmacological analysis of the mixed discriminative stimulus effects of ethanol. Alcohol Alcohol Suppl 2:445-449.
20. Grant KA, Colombo G (1993b). Substitution of the 5HT1 agonist trifluoromethyl-phenylpiperazine (TFMPP) for the discriminative stimulus effects of ethanol: effect of training dose. Psychopharmacology (Berl) 113:26-30.
21. Grant KA, Lovinger DM (1995). Cellular and behavioral neurobiology of alcohol: receptor-mediated neuronal processes. Clin Neurosci 3:155-164.
22. Grant KA, Knisely JS, Tabakoff B, Barrett JE, Balster RL (1991). Ethanol-like discriminative stimulus effects of non-competitive N-methyl-D-aspartate antagonists. Behav Pharmacol 2:87-95.
23. Grant KA, Azarov A, Bowen CA, Mirkis S, Purdy RH (1996). Ethanol-like discriminative stimulus effects of the neurosteroid 3α-hydroxy-5α- pregnan-20-one in female Macaca fascicularis monkeys. Psychopharmacology (Berl) 124:340-346.
24. Grant KA, Colombo G, Gatto GJ (1997). Characterization of the ethanol-like discriminative stimulus effects of 5HT1 receptor agonists as a function of ethanol training dose. Psychopharmacology (Berl) 133:133-141.
25. Green KL, Grant KA (1998). Evidence for overshadowing by components of the heterogeneous discriminative stimulus effects of ethanol. Drug Alcohol Depend 52:149-159.
26. Green-Jordan K, Grant KA (2000). Modulation of the ethanol-like discriminative stimulus effects of diazepam and phencyclidine by L-type voltage-gated calcium-channel ligands in rats. Psychopharmacology (Berl) 149:84-92.
27. A receptors in the acute and chronic effects of ethanol. Psychopharmacology (Berl) 139:2-19.
28. Harrison YE, Jenkins JA, Rocha BA, Lytle DA, Jung ME, Oglesby MW (1998). Discriminative stimulus effects of diazepam, ketamine and their mixture: ethanol substitution patterns. Behav Pharmacol 9:31-40.
29. Hiltunen AJ, Jarbe TU (1986). Discrimination of RO 11-6896, chlordiazepoxide and ethanol in gerbils: generalization and antagonism tests. Psychopharmacology (Berl) 89:284-290.
30. Holtzman SG (1990.) Discriminative stimulus effects of drugs: relationship to potential for abuse. In: Adler MW, Cowan A (editors): Modern Methods in Pharmacology. Testing and Evaluation of Drugs of Abuse, vol. 6. New York: Wiley-Liss; pp. 193-210.
31. Hundt W, Danysz W, Holter SM, Spanagel R (1998). Ethanol and N-methyl-D-aspartate receptor complex interactions: a detailed drug discrimination study in the rat. Psychopharmacology (Berl) 135:44-51.
32. Jarbe TU, McMillan DE (1983). Interaction of the discriminative stimulus properties of diazepam and ethanol in pigeons. Pharmacol Biochem Behav 18:73-80.
33. Jarbe TU, Hiltunen AJ, Swedberg MDB (1989). Compound drug discrimination learning. Drug Dev Res 16:111-122.
34. Koek W (1999). N-Methyl-D-Aspartate antagonists and drug discrimination. Pharmacol Biochem Behav 64:275-281.
35. Koek W, Colpaert FC, Vignon J (1993). Effects of phencyclidine-type drugs in rats discriminating fentanyl from saline: pharmacological and behavioral characterization of intermediate levels of drug lever selection. J Pharmacol Exp Ther 264:746-756.
36. A receptors. Prog Neurobiol 67:113-159.
37. Lelas S, Gerak LR, France CP (1999). Discriminative-stimulus effects of triazolam and midazolam in rhesus monkeys. Behav Pharmacol 10:39-50.
38. Mackintosh NJ (1974). The Psychology of Animal Learning. New York: Academic Press; pp. 543-619.
39. Mariathasan EA, Stolerman IP, White J-AW (1997). Antagonism of AND and AND-OR drug mixture discriminations in rats. Drug Alcohol Depend 44: 31-34.
40. 2C receptors in the generalization of 5-HT receptor agonists to the ethanol cue in the rat. Behav Pharmacol 9:337-343.
41. A modulators to substitute for a midazolam discriminative stimulus in untreated monkeys does not predict potency to attenuate flumazenil discriminative stimulus in diazepam-treated monkeys. J Pharmacol Exp Ther 298:1227-1235.
42. Purdy RH, Morrow AL, Blinn JR, Paul SM (1990). Synthesis, metabolism and pharmacological activity of 3α-hydroxy steroids which potentiate GABA-receptor mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes. J Med Chem 33:1572-1581.
43. 3H]TCP binding sites in guinea pig brain. In: Kamenka J-M, Domino EF (editors): Multiple Sigma and PCP Receptor Ligands. Ann Arbor: NPP Books; pp. 137-146.
44. Sanger DJ (1993). Substitution by NMDA antagonists and other drugs in rats trained to discriminate ethanol. Behav Pharmacol 4:523-528.
45. Sannerud CA, Ator NA (1995). Drug discrimination analysis of midazolam under a three-lever procedure: I. dose-dependent differences in generalization and antagonism. J Pharmacol Exp Ther 272:100-111.
46. Schechter MD, Lovano DM (1985). Ethanol-chlordiazepoxide interactions in the rat. Pharmacol Biochem Behav 23:927-930.
47. Sellers EM, Higgins GA, Sobell MB (1992). 5-HT and alcohol abuse. Trends Pharmacol Sci 13:69-75.
48. Shelton KL, Balster RL (1994). Ethanol drug discrimination in rats: substitution with GABA agonists and NMDA antagonists. Behav Pharmacol 5:441-450.
49. Signs SA, Schechter MD (1988). The role of dopamine and serotonin receptors in the mediation of the ethanol interoceptive cue. Pharmacol Biochem Behav 30:55-64.
50. Sircar R, Rappaport M, Nichtenhauser R, Zukin SR (1987). The novel anticonvulsant MK 801: a potent and specific ligand of the brain phencyclidine/sigma receptor. Brain Res 435:235-240.
51. Spealman RD (1985). Discriminative stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by RO 15-1788. J Pharmacol Exp Ther 235:456-462.
52. Stolerman IP, Mariathasan EA (1990). Discrimination of an amphetamine-pentobarbitone mixture by rats in an AND-OR paradigm. Psychopharmacology (Berl) 102:557-560.
53. Woundenberg F, Slanger JL (1989). Discriminative stimulus properties of midazolam: comparison with other benzodiazepines. Psychopharmacology (Berl) 97:466-470.
54. York JL (1978). A comparison of the discriminative stimulus effects of ethanol, barbital and phenobarbital in rats. Psychopharmacology (Berl) 60: 19-23.