Treatment of bronchial asthma with tianeptine

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 26, Issue 9, 2004, Pages 697-701

  Lechin, Fuad ^a,c   Van Der Dijs, B ^a   Lechin, A E ^b  

^a UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^b UNIVERSITY OF HOUSTON COLLEGE OF MEDICINE   (United States)

^c NONE   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADRENALIN; CATECHOLAMINE; NORADRENALIN; SEROTONIN; TIANEPTINE;

ASTHMA; AUTONOMIC NERVOUS SYSTEM; BRONCHOSPASM; CATECHOLAMINE RELEASE; CONTROLLED STUDY; HUMAN; IMMUNE SYSTEM; LUNG; MAJOR CLINICAL STUDY; NEUROSECRETORY CELL; REVIEW; SEROTONINERGIC SYSTEM; SLEEP DISORDER; TREATMENT OUTCOME;

ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; CLINICAL TRIALS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; HUMANS; THIAZEPINES;

EID: 11344251914     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2004.26.9.872567     Document Type: Review

References (65)

1. Mennini, T., Mocaer, E., Garattini, S. Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn Schmiedeberg's Arch Pharmacol 1987, 336: 478-82.
2. Fattaccini, C.M., Bolaños Jiménez, F., Gozlam, H. Tianeptine stimulates uptake of 5′hydroxy'tryptamine in vivo in the rat brain. Neuropharmacology 1990, 29: 1-8.
3. Ortiz, J., Mocaer, E., Artigas, F. Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat. Eur J Pharmacol 1991, 199: 335-9.
4. Ortiz, J., Mariscot, C., Alvarez, E. Effects of the antidepressant drug tianeptine on plasma and platelet serotonin of depressive patients and healthy controls. J Affect Disord 1993, 29: 227-34.
5. Black, J.L., Johnson, P.R. Airway smooth muscle in asthma. Respirology 1996, 1: 153-8.
6. Nadel, J.A., Busse, W.W. Asthma. Am J Respir Crit Care Med 1998, 157: S130-8.
7. 2+ mobilization in airway smooth muscle contributes to airway hyperresponsiveness in an inbred strain of rat. Am J Respir Cell Mol Biol 1999, 160: 446-53.
8. 2+ signaling in lung slices from different mouse strains. J Appl Physiol 2003, 95: 1325-32.
9. Barnes, P.J., Chung, K.F., Page, C.P. Inflammatory mediators of asthma: An update. Pharmacol Rev 1998, 50: 15-96.
10. Lauweryns, J.M., van Ranst, L., Lloyd, R.V., O'Connor, D.T. Chromogranin in bronchopulmonary neuroendocrine cells. Immunocytochemical detection in human, monkey, and pig respiratory mucosa. J Histochem Cytochem 1987, 35: 113-8.
11. Ahlman, H., Bhargava, H.N., Dahlstrom, A., Larsson, I., Newson, B., Petterson, G. On the presence of serotonin in the gut lumen and possible release mechanisms. Acta Physiol Scand 1981, 112: 263-9.
12. Burks, T.F., Long, J.P. Catecholamine-induced release of 5-hydroxytryptamine from perfused vasculature of isolated dog intestine. J Pharm Sci 1966, 55: 1383-6.
13. Larssson, I., Ahlman, H., Bhargava, H.N., Dahlstrom, A., Petterson, G., Kewenter, J. The effects of splanchnic nerve stimulation on the plasma levels of 5-HT and SP in the portal vein of the cat. J Neural Transm 1979, 46: 105-12.
14. Kjellstrom, T., Ahlman, H., Dahlstrom, A. and Risberg, B. The cellular uptake in the rat lung in vivo: A histochemical study. Acta Physiol Scand 1982, 116: 455-60.
15. Born, G.V., Gillson, R.E. Studies on the uptake of 5-hydroxy-tryptamine by blood platelets. J Physiol 1959, 146: 472-91.
16. Davis, R.B., Wang, Y. Rapid pulmonary removal of 5-hydroxytryptamine in the intact dog. Proc Soc Exp Biol 1965, 118: 799-800.
17. Gillis, C.N., Cronau, L.H., Mandel, S., Hammond, G.L. Indicator dilution measurements of 5-hydroxytryptamine clearance by human lung. J Appl Physiol 1979, 46: 1178-83.
18. Keith, IM., Will, J.A. Dynamics of the neuroendocrine cell-regulatory peptide system in the lung. Specific overview and new results. Exp Lung Res 1982, 3: 387-402.
19. Moosavi, H., Smith, P., Heath, D. The Feyrter cell in hypoxia. Thorax 1973, 28: 729-741.
20. Johnson, D.E., Georgieff, M.K. Pulmonary neuroendocrine cells. Their secretory products and their potential roles in health and chronic lung disease in infancy. Am Rev Respir Dis 1989, 140: 1807-12.
21. Levitt, R.C., Mitzner, W. Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytryptamine. J Appl Physiol 1989, 67: 1125-32.
22. Lechin, F., van der Dijs, B., Jackubowicz, D. et al. Effects of clonidine on blood pressure, noradrenaline, cortisol, growth hormone, and prolactin plasma levels in high and low intestinal tone subjects. Neuroendocrinology 1985, 40: 253-61.
23. Lechin, F., van der Dijs, B., Lechin, M. et al. Effects of an oral glucose load on plasma neurotransmitters in humans: involvement of REM sleep? Neuropsychobiology 1992, 26: 4-11.
24. Tobe, T., Izumikawa, F., Sano, M. and Tanaka, C. Release mechanisms of 5-HT in mammalian gastrointestinal tract-especially vagal release of 5-HT. In: Endocrine Gut-Pancreas. Fujita, T. (Ed.). Elsevier: Amsterdam 1976, 371-80.
25. Schworer, H., Racke, K., Kilbinger, H. Cholinergic modulation of the release of 5-hydroxytryptamine from the guinea pig ileum. Naunyn-Schmiedeberg's Arch Pharmacol 1987, 336: 127-32.
26. Rausch, J.L., Janowsky, D.S., Risch, S.C., Huey, L.Y. Physostigmine effects on serotonin uptake in human blood platelets. Eur J Pharmacol 1985, 109: 91-6.
27. Gronstad, K.O., Zinner, M.J., Nilsson, O., Dahlstrom, A., Jaffe, B.M., Ahlman, H. Vagal release of serotonin into gut lumen and portal circulation via separate control mechanisms. J Surg Res 1987, 43: 205-10.
28. Vesifeld, I.L., Vasiljiev, V.N., Iljicheva, R.F. Relationship of catecholamines, histamine and serotonin in men under different kinds of stress. In: Catecholamines and Stress. Usdin, E., Kvetnansky, R., Kopin, I.J. (Eds.). Pergamon Press: Oxford 1976, 527-8.
29. Lechin, F., van der Dijs, B., Lechin, M.E. Bronchial asthma. In: Neurocircuitry and Neuroautonomic Disorders. Reviews and Therapeutic Strategies. Lechin, F., van der Dijs, B., Lechin, M.E. (Eds.). Karger: Basel 2002, 66-8.
30. Dupont, L.J., Pype, J.L., Demedts, M.G., De Leyn, P., Deneffe, G., Verleden, G.M. The effects of 5-HT on cholinergic contraction in human airways in vitro. Eur Respir J 1999, 14: 642-9.
31. Takahashi, T., Ward, J.K., Tadjkarimi, S., Yacoub, M.H., Barnes, P.J., Bolvisi, M.G. 5-Hydroxytryptamine facilitates cholinergic bronchoconstriction in human and guinea pig airways. Am J Respir Crit Care Med 1995, 152: 377-80.
32. Gunst, S.J., Tang, D.D. The contractile apparatus and mechanical properties of airway smooth muscle. Eur Respir J 2000, 15: 600-16.
33. Hall, I.P. Second messengers, ion channels and pharmacology of airway smooth muscle. Eur Respir J 2000, 15: 1120-7.
34. 2+) regulation in airway smooth muscle contraction: Do the data contradict dogma? Am J Physiol Lung Cell Mol Physiol 2002, 282: L1161-78.
35. Lechin, F., van der Dijs, B., Orozco, B. et al. The serotonin uptake-enhancing drug tianeptine suppressess asthmatic symptoms in children: A double-blind, crossover placebo-controlled study. J Clin Pharmacol 1998, 38: 918-25.
36. Lechin, F., van der Dijs, B., Orozco, B. et al. Neuropharmacological treatment of bronchial asthma with the antidepressant tianeptine: A double-blind, crossover placebo-controlled study. Clin Pharmacol Ther 1998, 64: 223-32.
37. Lechin, F., van der Dijs, B., Lechin, A.E. Tianeptine: A new exploratory therapy for asthma. Chest 2004, 125: 348-49.
38. Lechin, F. Asthma, asthma medication and autonomic nervous system dysfunction. Clin Physiol 2001, 6: 723.
39. Lechin, F., van der Dijs, B., Lechin, A.E. Serotonin, pulmonary hypertension and bronchial asthma. Clin Sci 2002, 103: 345-6.
40. Lechin, F., van der Dijs, B., Lechin, A.E. Pulmonary hypertension, left ventricular dysfunction and plasma serotonin. Br J Pharmacol 2002, 137: 937-8.
41. Lechin, F., van der Dijs, B. and Lechin, A.E. Tianeptine, plasma serotonin and pulmonary hypertension. Lancet 2003, 361: 87.
42. Lechin, F., van der Dijs, B. Serotonin and pulmonary vasoconstriction. J Appl Physiol 2002, 3: 1363-4.
43. Lechin, F., van der Dijs, B., Lechin, A.E. Severe asthma and plasma serotonin. Allergy 2002, 57: 258-59.
44. Lechin, F. Central and plasma 5-HT, vagal tone and airways. Trends Pharmacol Sci 2000, 21: 425.
45. Lechin, F., van der Dijs, B., Jara, H. et al. Effects of buspirone on plasma neurotransmitters in healthy subjects. J Neural Transm 1998, 105: 561-73.
46. Lechin, F., van der Dijs, B., Lechin, M.E. Central neurocircuitry functioning during the wake-sleep cycle. In: Neurocircuitry and Neuroautonomic Disorders. Reviews and Therapeutic Strategies. Lechin, F., van der Dijs, B., Lechin, M.E. (Eds.). Karger: Basel 2002, 3-13.
47. Belohlavkova, S., Simak, J., Kokesova, A., Hnilickova, O., Hampl, V. Fenfluramine-induced pulmonary vasoconstriction: Role of serotonin receptors and potassium channels. J Apply Physiol 2001, 91: 755-61.
48. Cazzola, I., Mattera, M.G. 5-HT modifiers as a potential treatment of asthma. Trends Pharmacol Sci 2000, 21: 13-16.
49. Ogren, S.O., Fuxe, K., Archer, T., Johansson, G., Holm, A.C. Behavioral and biochemical studies on the effect of acute and chronic administration of antidepressant drugs on central serotonergic receptor mechanisms. In: New Vistas in Depression. Langer, S., Takahashi, R., Segawa, T., Briley, M. (Eds.). Pergamon Press: New York 1982, 171-8.
50. Maj, J. Pharmacological spectrum of some new antidepressants. In: Advances in Pharmacology and Therapeutics. Dumond, C. (Ed.). Pergamon Press: New York 1978, 161-70.
51. Leonard, B.E., Kafoe, W. A comparison of acute and chronic effects of four antidepressant drugs on the turnover of serotonin, dopamine and noradrenaline in the rat brain. Biochem Pharmacol 1976, 25: 1939-42.
52. Scuvee-Moreau, J.J., Dresse, A.L. Effects of various antidepressant drugs on the spontaneous firing rate of locus coeruleus and raphe dorsalis neurons of the rat. Eur J Pharmacol 1979, 57: 219-25.
53. Raiteri, M., Angellini, F., Bertollini, A. Comparative studies of the effects of mianserin, a tetracyclic antidepressant and of imipramine on uptake and release of neurotransmitters in synaptosomes. J Pharm Pharmacol 1976, 28: 483-8.
54. Lechin, F., Pardey-Maldonado, B., van der Dijs, B. et al. Plasma neurotransmitters throughout the wake-sleep cycle in normal subjects. Psychoneuroendocrinology 2004 (In Press).
55. Lechin, F., van der Dijs, B., Amat, J., Lechin, M.E. Neuroanatomical basis. In: Neurochemistry and Clinical Disorders: Circuitry of some Psychiatric and Psychosomatic Syndromes. Lechin, F., van der Dijs, B. (Eds). CRC Press: Boca Raton 1989: 2-48.
56. Lechin, F., van der Dijs, B., Orozco, B., et al.. Plasma neurotransmitters, blood pressure and heart rate during supine resting, orthostasis and moderate exercise in severelly ill patients: a model of failing to cope with stress. Psychother Psychosom 1996, 65: 129-136.
57. Lokhandwala, M.F., Hedge, S.S. Cardiovascular dopamine receptors: role of renal dopamine and dopamine receptors in sodium excretion. Pharmacol Toxicol 1990, 66: 237-43.
58. 2 receptors: A mechanism limiting excessive sympathic-adrenal discharge in humans. J Clin Endocrinol Metab 1988, 66: 626-31.
59. Mercuro, G., Gessa, G., Rivano, C.A., Lai, L., Cherchi, A. Evidence for a dopaminergic control of sympathoadrenal catecholamines release. Am J Cardiol 1988, 62: 827-8.
60. Lechin, A.E., Varon, J., van der Dijs, B., Lechin, F. Plasma catecholamines and indolamines during attack and remission on severe bronchial asthma: Possible role of stress. Am J Respir Crit Care Med 1994, 149: A778.
61. Lechin, A.E., Varon, J., van der Dijs, B., Lechin, F. Plasma neurotransmitters, blood pressure and heart rate during rest and exercise. Am J Respir Crit Care Med 1994, 149: A482.
62. Lechin, F., van der Dijs, B., Orozco, B., Lechin, M.E., Lechin, A.E. Increased levels of free serotonin in plasma of symptomatic, asthmatic patients. Ann Allergy Asthma Immunol 1996, 77: 245-53.
63. Larsson, P.T., Hjemdhal, P., Olsson, G., Egberg, N., Hornstra, G. Altered platelet function during mental stress and adrenaline infusion in humans: Evidence for an increased aggregability in vivo as measured by filtragometry. Clin Sci 1989, 76: 369-76.
64. Capron, A., Joseph, M., Ameisen, J.C., Capron, M., Pancre, V., Auriault, C. Platelets as effectors in immune and hypersensitivity reactions. Int Arch Allergy Appl Immunol 1987, 82: 307-12.
65. Hechtman, H.B., Lonergan, E.A., Staunton, H.P., Dennis, R.C., Shepro, D. Pulmonary entrapment of platelets during acute respiratory failure. Surgery 1978, 83: 277-83.