The serotonin uptake-enhancing drug tianeptine suppresses asthmatic symptoms in children: A double-blind, crossover, placebo-controlled study

Journal of Clinical Pharmacology

Volumn 38, Issue 10, 1998, Pages 918-925

  Lechin, Fuad ^a,c,g   Van Der Dijs, Bertha ^a,c   Orozco, Beatriz ^a,c   Jara, Hector ^a,b,c   Rada, Isais ^d   Lechin, Marcel E ^e   Lechin, Alex E ^f  

^a UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^b Miguel Perez Carreño Hospital   (Venezuela)

^c Centro Clinico Profesional Caracas   (Venezuela)

^d Baquero Gonzalez Hospital   (Venezuela)

^e TEXAS A M COLLEGE OF MEDICINE   (United States)

^f BAYLOR COLLEGE OF MEDICINE   (United States)

^g NONE   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

SALBUTAMOL; SEROTONIN; TIANEPTINE;

ADOLESCENT; ARTICLE; ASTHMA; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PEAK EXPIRATORY FLOW; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEROTONIN UPTAKE; SPIROMETRY; THROMBOCYTE;

EID: 0031757638     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1998.tb04387.x     Document Type: Article

References (83)

1. Lechin F, van der Dijs B, Orozco B, Lechin ME, Lechin ARE: Increased free-serotonin plasma levels in symptomatic asthmatic patients. Ann Allergy Asthma Immunol 1996;77:245-253.
2. Lechin F, van der Dijs B, Rada I, Jara H, Lechin A, Cabrera A, et al: Plasma neurotransmitters and cortisol in duodenal ulcer patients: role of stress. Dig Dis Sci 1990;35:1313-1319.
3. Lechin F, van der Dijs B, Lechin ME, Amat J, Lechin ARE, Cabrera A, et al: Pimozide therapy for trigeminal neuralgia. Arch Neural 1989;46:960-963.
4. Lechin F, van der Dijs B: Physiological, clinical and therapeutical basis of a new hypothesis for headache. Headache 1980;20: 77-83.
5. Lechin F, van der Dijs B, Lechin M, Jara H, Lechin A, Lechin-Baez S, et al: Plasma neurotransmitters throughout an oral glucose tolerance test in essential hypertension. Clin Exp Hypertens 1993; 5:209-240.
6. Lechin F, van der Dijs B, Lechin A, Lechin M, Coll-García E, Jara H, et al: Doxepin therapy for postprandial symptomatic hypoglycemic patients neurochemical, hormonal and metabolic disturbances. Clin Sci 1991;80:373-384.
7. Lechin F, van der Dijs B, Vitelli G, Lechin S, Azócar J, Cabrera A, et al: Behavioural, neurochemical, hormonal and immunological profiles in 50 advanced cancer patients: spontaneous postsurgical evolution. Psychoneuroendocrinology 1991;15:435-451.
8. Lechin F, van der Dijs B, Insausti CL, Gomez F, Villa S, Lechin AE, et al: Treatment of ulcerative colitis with clonidine. J Clin Pharmacol 1985;25:219-226.
9. Lechin F, van der Dijs B, Lechin S, Vitelli G, Lechin ME, Cabrera A: Neurochemical, hormonal and immunological views of stress: clinical and therapeutic implications in Crohn's disease and cancer. In, Velazco M (ed.): Recent Advances in Pharmacology and Therapeutics. International Congress Series, Volume 839. Amsterdam: Excerpta Medica, 1989;57-70.
10. Lechin F, van der Dijs B, Lechin M, Jara H, Lechin A, Cabrera A, et al: Dramatic improvement with clonidine of acute pancreatitis showing raised catecholamines and cortisol plasma levels: case report of five patients. J Med 1992;23:339-351.
11. Lechin F, van der Dijs B, Lechin AE, Orozco B, Lechin ME, Baez S, et al: Plasma neurotransmitters and cortisol in chronic illness: role of stress. J Med 1994;25:181-192.
12. Lechin F, van der Dijs B, Benaim M: Stress and depression (review). Prog Neuropsychopharmacol Biol Psychiatry 1996;20: 899-950.
13. Lechin F, van der Dijs B, Orozco B, Lechin ME, Acosta E, Lechin AE, et al: Plasma neurotransmitters, blood pressure and heart rate during supine-resting, orthostasis and moderate exercise conditions in major depressed patients. Biol Psychiatry 1995; 38:166-173.
14. Lechin F, van der Dijs B, Orozco B, Lechin AE, Baez S, Lechin ME, et al: Plasma neurotransmitters, blood pressure and heart rate during supine-resting, orthostasis and moderate exercise in dysthymic depressed patients. Biol Psychiatry 1995;37:884-891.
15. Mennini T, Mocaer E, Garattini S: Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn Schmiedebergs Arch Pharmacol 1987;336:478-482.
16. Fattaccini CM, Bolaños Jimenez F, Gozlam H: Tianeptine stimulates uptake of 5-hydroxytryptamine in vivo in the rat brain. Neuropharmacology 1990;29:1-8.
17. Ortiz J, Mocaer E, Artigas F: Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat. Eur J Pharmacol 1991;199:335-339.
18. Garattini S: Tianeptine enhances 5HT-uptake and inhibits experimental depression and stress (abstract). Am J Psychiatry 1993;150(suppl 4):1402.
19. Chamba G, Lemoine P, Flachaire E: Increased serotonin platelet uptake after tianeptine administration in depressed patients. Boil Psychiatry 1991;5:609-617.
20. Ortiz J, Mariscot C, Alvarez E: Effects of the antidepressant drug tianeptine on plasma and platelet serotonin of depressive patients and healthy controls. J Affect Disord 1993;29:227-234.
21. Delbende C, Contesse V, Mocaer E: The novel antidepressant tianeptine reduces stress-evoked stimulation of the hypothalamopituitary-adrenal axis. Eur J Pharmacol 1991;202:391-396.
22. Wilde MI, Benfield P: Tianeptine (review). Drugs 1995;49: 411-439.
23. American Thoracic Society: Standard for diagnosis and care of patients with chronic obstructive pulmonary disease and asthma. Am Rev Respir Dis 1987;136:225-245.
24. Nadel JA, Davis B: Autonomic regulation of mucus secretion and ion transport in airways. In, Lictenstein LM, Austen KF (eds.): Asthma: Physiology, Immunopharmacology, and Treatment. New York: Academic Press, 1977;197-210.
25. 2-adrenoceptors. J Appl Physiol 1988;65:700-705.
26. Rebuck AS, Chapman KR, Abboud R: Nebulized anticholinergic and sympathomimetic treatment of asthma and chronic obstructive airways disease in the emergency room. Am J Med 1987; 82:59-64.
27. Curry JJ: Comparative action of acetyl-beta-methylcholine and histamine on the respiratory tract in normals, patients with hay fever, and subjects with bronchial asthma. J Clin Invest 1947;26: 430-438.
28. Juniper EF, Frith PA, Hargreave FE: Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma. Thorax 1981;36:575-579.
29. Undem BJ: Asthma: Physiology, Immunopharmacology, and Treatment. San Diego: Academic Press, 1993.
30. Cazzola M, Matera MG, D'Amato G, Rossi F: Effects of serotonin on airways: recent developments. Allergy 1995;50:1-10.
31. Tobe T, Izumikawa F, Sano M, Tanaka C: Release mechanisms of 5-HT in mammalian gastrointestinal tract-especially vagal release of 5-HT. In, Fujita T (ed.): Endocrine Gut-Pancreas. Amsterdam: Elsevier, 1976;371-380.
32. Gronstad KO, Zinner MJ, Dahlstrom A: Vagal release of serotonin into gut lumen and portal circulation via separate control mechanisms. J Surg Res 1987;43:205-210.
33. Born GV, Gillson RE: Studies on the uptake of 5-hydroxytryptamine by blood platelets. J Physiol 1959;146:472-491.
34. Wirz-Justice A, Lichsteiner M, Peer H: Diurnal and seasonal variations in human platelet serotonin in man. J Neural Transm 1977;41:7-15.
35. Launay G, Costa JL, Da Prada M, Launay JM: Estimation of rate constants for serotonin uptake and compartmentation in normal human platelets. Am J Physiol 1994;266:R1061-1075.
36. Lechin F, Coll-Garcia E, van der Dijs B, Peña F, Bentolila A, Rivas C: The effect of serotonin (5-HT) on insulin secretion. Acta Physiol Latinoamer 1975;25:339-346.
37. Endo Y: Evidence that the accumulation of 5-hydroxytryptamine in the liver but not in the brain may cause the hypoglycemia induced by 5-hydrotryptophan. Br J Pharmacol 1985;81:645-650.
38. Kjellstrom T, Ahlman H, Dahlstrom A, Risberg B: The cellular uptake in the rat lung in vivo: a histochemical study. Acta Physiol Scand 1982;116:455-460.
39. Lechin F, van der Dijs B, Lechin M, Lechin-Baez S, Jara H, Lechin A, et al: Effects of an oral glucose load on plasma neurotransmitters in humans: involvement of REM sleep? Neuropsychobiology 1992;26:4-11.
40. Anderson GM, Stevenson JM, Cohen DJ: Steady state model for plasma free and platelet serotonin in man. Life Sci 1987;41: 1777-1785.
41. Rausch JL, Janowsky DS, Risch SC, Huey LY: Physostygmine effects on serotonin uptake in human blood platelets. Eur J Pharmacol 1985;109:91-96.
42. Macquin-Mavier L, Jarreau PH, Istin N, Harf A: 5-Hydroxytryptamine-induced bronchoconstriction in the guinea pig: effect of 5HT2 receptor activation on acetylcholine release. Br J Pharmacol 1991;102:1003-1007.
43. Rizzo AC, Kreutner W, Chapman RW: 5HT3 Receptors augment neuronal cholinergic contractions in guinea pig trachea. Eur J Pharmacol 1993;234:109-112.
44. Sheller JR, Holtzman MJ, Skoogh BE, Nadel JA: Interaction of serotonin with vagal-and ACh-induced bronchoconstriction in canine lungs. J Appl Physiol 1982;52:04-66.
45. Van Oosterhout AJM, Hofman G, van Kunanten W, Nijkamp FP: 5HT1 receptors mediate potentiation of cholinergic nervemediated contraction of isolated mouse trachea. Eur J Pharmacol 1991;209:237-244.
46. Szarek JL, Zhang JZ, Gruetter CA: 5-HT2 receptors augment cholinergic nerve-mediated contraction of rat bronchi. Eur J Pharmacol 1993;231:339-446.
47. Aas P: Serotonin induced release of acetylcholine from neurons in the bronchial smooth muscle of the rat. Acta Physiol Scand 1983;117:477-480.
48. Lucchelli A, Santagostino-Barbone MG, Barbieri A, Tonini MA: A pharmacological analysis of receptors mediating the excitatory response to 5-hydroxytryptamine in the guinea pig isolated trachea. Br J Pharmacol 1994;112:763-768.
49. Baumgartner RA, Wills-Karp M, Kaufman MJ, Munakata M, Hirshman C: Serotonin induces constriction and relaxation of the guinea pig airway. J Pharmacol Exp Ther 1990;255:165-173.
50. Hahn HL, Wilson AG, Graf PD, Fischer SP, Nadel JA: Interactions between serotonin and efferent vagus nerves in dog lungs. J Appl Physiol 1978;44:144-149.
51. Islam MD, Melville GN, Ulmer WT: Role of atropine in antagonizing the effects of 5-hydroxytryptamine (5HT) on bronchial and pulmonary vascular systems. Respiration 1974;31:47-50.
52. Lechin F, van der Dijs B, Orozco B, Lechin AE, Baez S, Lechin ME, et al: Plasma neurotransmitters, blood pressure and heart rate during supine-resting, orthostasis and moderate exercise in severely ill patients: a model of failing to cope with stress. Psychother Psychosom 1996;65:129-136.
53. Lechin F, van der Dijs B, Jara H, Orozco B, Benaim M: Plasma neurotransmitters and functional illness. Psychother Psychosom 1996;65:293-318.
54. Lechin AE, Varon J, van der Dijs B, Lechin F: Plasma catecholamines and indoleamines during attacks and remission on severe bronchial asthma: posible role of stress (abstract). Am J Respir Crit Care Med 1994;149:A778.
55. Nemtsov V, Kachanova T, Fedoseev G, Zhikharev SS: Serotonin level and vascular disturbances in bronchial asthma (ab-stract). Chest 1994;106:146S.
56. Hay M, Bishop VS: Effects of area postrema stimulation on neurons of the nucleus solitary tract. Am J Physiol 1991;260: H1359-H1364.
57. Reynolds DJM, Leslie RA, Grahame-Smith DG, Harvey JM: Localization of 5HT3 receptor binding sites in human dorsal vagal complex. Ear J Pharmacol 1989;174:27-30.
58. 3) receptors within the blood-brain barrier prevents cisplatininduced emesis in dogs. J Pharmacol Exp Ther 1995;273:695-701.
59. Cubeddu LX, Hoffman IS, Fuenmayor NT, Finn AL: Efficacy of ondansetron (GR38032F) and the role of serotonin in cisplatininduced nausea and vomiting. N Engl J Med 1990;322:810-816.
60. 3 receptor mediated cisplatin-induced emesis in dogs. Jpn J Pharmacol 1992;59:221-226.
61. Ireland SJ, Tyres MB: Pharmacological characterization of 5-hydroxy-tryptamine-induced depolarization of the rat isolated vagus nerve. Br J Pharmacol 1987;90:229-238.
62. 3 receptor agonists in the cat: effects of vagotomy, splanchnicectomy or area postrema lesion. J Pharmacol Exp Ther 1992; 260:509-517.
63. Glusa E, Richter M: Endothelium-dependent relaxation of porcine pulmonary arteries via 5HT1C-like receptors. Naunyn Schmiedebergs Arch Pharmacol 1993;347:471-477.
64. Dixon M, Jackson DM, Richards IM: The effects of 5-hydroxytryptamine, histamine and acetylcholine on the reactivity of the lung of the anesthetized dog. J Physiol 1980;307:85-96.
65. McFadden ER Jr: Evolving concepts in the pathogenesis and management of asthma. Adv Intern Med 1994;39:357-394.
66. Marin MG: Update: pharmacology of airway secretion. Pharmacol Rev 1994;46:35-65.
67. Tokuyama K, Kuo H-P, Rohde JA, Barnes PJ, Rogers DF: Neural control of globet cell secretion in guinea pig airways. Am J Physiol 1990;259:L108-L115.
68. Barnes PJ: Neuropeptides and asthma (abstract). Am Rev Respir Dis 1991;143:S28.
69. Ackerman V, Carpi S, Bellini A: Constitutive expression of endothelin in bronchial epithelial cells of patients with symptomatic and asymptomatic asthma and modulation by histamine and interleukin-1. J Allerg Clin Immunol 1995:96:618-627.
70. Hanania NA, Chapman KR, Stutridge WC: Dose-related decrease in bone density among asthmatic patients treated with inhaled corticosteroids. J Allerg Clin Immunol 1995;96:571-579.
71. Persson CGA: Plasma exudation and asthma. Lung 1988;166: 1-23.
72. Jonderko G, Kwiatek R, Bierowiec J: Effect of joint administration of antagonists of serotonin, histamine and acetylcholine on ventilatory disorders in asthma. Pol Tyg Lek 1978;33:1219-1221.
73. Bariffi F: Trends in the treatment of bronchial asthma. Clin Ter 1975;73:505-521.
74. Beyer E: Studies on the histamine-, serotonin-and acetylcholine-antagonism of dexamethasone21-isonicotinate. Arzneimittelforschung 1968;18:1312-1313.
75. Scarpa GL: Effects of decloxizine on clinical symptomatology, respiratory function and cutaneous reaction to serotonin in asthmatic patients. Acta Tuberc Pneumol Belg 1968;59:583-590.
76. Palma Carlos AG, Galvao Lucas J, Palma Carlos ML: The treatment of bronchial asthma with BP-400. Acta Allergol 1967; 22:387-398.
77. Chachaj W, Malolepszy J, Randowa D, Suchnicka R: The effects of deseril inhalations on ventilatory disturbances in allergic bronchial asthma. Pol Med J 1970;9:886-890.
78. Skaburskis M, Shardonofsky F, Milic-Emili J: Effect of serotonin on expiratory pulmonary resistance in cats. J Appl Physiol 1990;68:2419-2425.
79. Bianchi AL, Denavit-Saubie M, Champagnat J: Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters. Physiol Rev 1995;75:1-45.
80. Hosogai M, Matsuo S, Nakao S: Firing pattern and location of respiratory neurons in cat medullary raphe nuclei. Neurosci Let 1993;61:149-152.
81. Monteau R, Di Pasquale E, Hilaire G: Further evidences that various 5-HT receptors subtypes modulate central respiratory activity: in vitro studies with SR46349B. Eur J Pharmacol 1994;259: 71-74.
82. Lalley PM: The excitability and rhythm of medullary respiratory neurons in the cat are altered by the serotonin receptor agonist 5-methoxy-N,N,dimethyltryptamine. Brain Res 1994;648: 87-98.
83. Morin D: Compared effects of serotonin on the inspiratory activity of glossopharyngeal, vagal, hypoglossal and cervical motoneurones in neonatal rat brain stem-spinal cord preparations. Neurosci Let 1993;160:61-64.