Synthesis and potential anti-inflammatory activity of some tetrahydrophthalazinones

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 19, Issue 6, 2004, Pages 475-480

  Gouault, Nicolas ^a   Pinel, Benoit ^a   Cupif, Jean Francois ^a   Depince, Alexandra ^b   Martin Chouly, Corinne A E ^b   Belleguic, Chantal ^b,c   David, Michele ^a  

^a Institute de Chimie de'Rennes   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

4a,5,8,8a tetrahydrophthalazinon 1 ones; Anti inflammatory effect; Cyclative release; Diels Alder reaction; PDE4 inhibitors; Solid phase synthesis

Indexed keywords

2 (2 HYDROXYETHYL) 4,6,7 TRIMETHYL 4A,5,8,8A TETRAHYDROPHTHALAZIN 1(2H) ONE; 2,4 DIMETHYL 4A,5,8,8A TETRAHYDROPHTHALAZIN 1(2H) ONE; 2,4,6,7 TETRAMETHYL 4A,5,8,8A TETRAHYDROPHTHALAZIN 1(2H) ONE; 4 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YLMETHYL] 2,6,7 TRIMETHYL 4A,5,8,8A TETRAHYDROPHTHALAZIN 1(2H) ONE; 4 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YLMETHYL] 4A,5,8,8A TETRAHYDROPHTHALAZIN 1(2H) ONE; 4 METHYL 4A,5,8,8A TETRAHYDROPHTHALAZIN 1(2H) ONE; 4,6,7 TRIMETHYL 4A,5,8,8A TETRAHYDROPHTHALAZIN 1(2H) ONE; 6,7 DIMETHYL 4 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YLMETHYL] 4A,5,8,8A TETRAHYDROPHTHALAZIN 1(2H) ONE; 6,7 DIMETHYL 4 PHENYL 4A,5,8,8A TETRAHYDROPHTHALAZIN 1(2H) ONE; ANTIASTHMATIC AGENT; ANTIINFLAMMATORY AGENT; AZELASTINE; NEW DRUG; ROFLUMILAST; ROLIPRAM; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD SAMPLING; CHEMICAL PROCEDURES; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CYCLOADDITION; DIELS ALDER REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; PRIORITY JOURNAL;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; AMINOPYRIDINES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZAMIDES; CYCLOPROPANES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; LIPOPOLYSACCHARIDES; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PHTHALAZINES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; ROLIPRAM; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

BETULACEAE;

EID: 11244321815     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/14756360412331280536     Document Type: Article

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