The imbalance in the ratio of Th1 and Th2 helper lymphocytes in uraemia is mediated by an increased apoptosis of Th1 subset

Nephrology Dialysis Transplantation

Volumn 19, Issue 12, 2004, Pages 3084-3090

  Alvarez Lara, Maria Antonia ^a   Carracedo, Julia ^a   Ramírez, Rafael ^a   Martín Malo, Alejandro ^a   Rodríguez, Mariano ^a   Madueño, Juan Antonio ^a   Aljama, Pedro ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

Apoptosis; Bcl 2; Chronic kidney disease; Cytokines; Fas; Th1 Th2 lymphocytes

Indexed keywords

FAS ANTIBODY; FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; LIPOCORTIN 5; PROTEIN BCL 2;

ADULT; AGED; APOPTOSIS; ARTICLE; CELLULAR IMMUNITY; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; HELPER CELL; HEMODIALYSIS PATIENT; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LYMPHOCYTE COUNT; MALE; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL ANALYSIS; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; UREMIA; VOLUNTEER;

ADULT; AGED; APOPTOSIS; CHRONIC DISEASE; CREATININE; FEMALE; HUMANS; KIDNEY DISEASES; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; REFERENCE VALUES; TH1 CELLS; TH2 CELLS; UREMIA;

EID: 11244318308     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfh382     Document Type: Article

References (20)

1. Cendroglo M, Jaber BL, Balakrishnan VS, Perianayagam M, King AJ, Pereira BJ. Neutrophil apoptosis and dysfunction in uremia. J Am Soc Nephrol 1999; 10: 93-100
2. Fernández-Fresnedo G, Ramos MA, Gonzalez-Pardo MC, Martin de Francisco AL, López-Hoyos M, Arias M. B lymphopenia in uremia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2. Nephrol Dial Transplant 2000; 15: 502-510
3. Kaul H, Girndt M, Sester U, Sester M, Köhler H. Initiation of hemodialysis treatment leads to improvement of T cell activation in patients with end-stage renal disease. Am J Kidney Dis 2000; 35: 611-616
4. Mosman TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 2348-2357
5. Sester U, Sester M, Hauk M, Kaul H, Köhler H, Girndt M. T-cell activation follows Th1 rather than Th2 pattern in hemodialysis patients. Nephrol Dial Transplant 2000; 15: 1217-1223
6. Daichou Y, Kurashige S, Hashimoto S, Suzuki S. Characteristic cytokine products of Th1 and Th2 cells in hemodialysis patients. Nephron 1999; 83: 237-245
7. Libetta C, Rampino T, Dal Canton A. Polarisation of T-helper lymphocytes toward the Th2 phenotype in uremic patients. Am J Kidney Dis 2001; 38: 286-295
8. Yokoyama T, Nitta K, Futatsuyama K et al. Identification of T helper cell subsets in continuous ambulatory peritoneal dialysis patients. Nephron 2001; 89: 215-218
9. Nitta K, Akiba T, Kawashima A et al. Characterisation of Th1/Th2 profile in uremic patients. Nephron 2002; 91: 492-495
10. Meier P, Dayer E, Blanc E, Wauters JP. Early T cell activation correlates with expression of apoptosis markers in patients with end-stage renal disease. J Am Soc Nephrol 2002; 13: 204-212
11. Matsumoto Y, Shinzato T, Amano I et al. Relationship between susceptibility to apoptosis and Fas expression in peripheral blood T cells from uremic patients: a possible mechanism for lymphopenia in chronic renal failure. Biochem Biophys Res Commun 1995; 215: 98-105
12. Martin-Malo A, Carracedo J, Ramírez R et al. Effect of uremia and dialysis modality on mononuclear cell apoptosis. J Am Soc Nephrol 2000; 11: 936-942
13. Carracedo J, Ramírez R, Martín-Malo A, Rodríguez M, Aljama, P. Nonbiocompatible hemodialysis membranes induce apoptosis in mononuclear cell: the role of G-proteins. J Am Soc Nephrol 1998; 9: 46-53
14. Hetts SW. To die or not to die. An overview of apoptosis and its role in disease. J Am Med Assoc 1998; 279: 300-307
15. Chao DT, Korsmeyer SJ. Bcl-2 family: regulators of cell death. Annu Rev Immunol 1998; 16: 395-419
16. Brunner T, Mogil R, LaFace D et al. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 1995; 373: 441-444
17. Dosch HM, Cheung RK, Karges W, Pietropaolo M, Becker DJ. Persistent T cell anergy in human type I diabetes. J Immunol 1999; 163: 6933-6940.
18. Schulze-Koops H, Kalden JR. The balance of Th1/Th2 cytokines in rheumatoid arthritis. Best Pract Res Clin Rheumatol 2001; 15: 677-691
19. Refaeli Y, van Parijs L, Alexander SI, Abbas AK. Interferon γ is required for activation-induced death of T lymphocytes. J Exp Med 2002; 196: 999-1005
20. Jaber BL, Cendroglo M, Balakrishnan VS et al. Apoptosis of leukocytes: basic concepts and implications in uremia. Kidney Int 2001; 59 [Suppl 78]: s197-s205