Evaluation of citrinin occurrence and cytotoxicity in Monascus fermentation products

Journal of Agricultural and Food Chemistry

Volumn 53, Issue 1, 2005, Pages 170-175

  Liu, Biing Hui ^a   Wu, Ting Shuan ^a   Su, Mao Chang ^b   Ping Chung, Ching ^a   Yu, Feng Yih ^a,c  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c NONE   (Taiwan)

Author keywords

Citrinin (CTN); Cytotoxicity; HPLC; Monascus fermentation products

Indexed keywords

CITRININ; MYCOTOXIN;

AQUEOUS SOLUTION; ARTICLE; CELL DEATH; CELL STRAIN HEK293; CELL VIABILITY; CHOLESTEROL BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; EVALUATION; FERMENTATION; FOOD PRESERVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MONASCUS;

CELL DEATH; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRININ; DIETARY SUPPLEMENTS; EMBRYO; FERMENTATION; FOOD CONTAMINATION; HUMANS; KIDNEY; MONASCUS; MYCOTOXINS;

MONASCUS; MONASCUS PURPUREUS;

EID: 11244318188     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf048878n     Document Type: Article

References (41)

1. CAST. Mycotoxins: Risks in Plant, Animal, and Human Systems. Council of Agricultural Science and Technology, Task Force Report 139; CAST: Ames, IA, 2003.
2. Gokmen, V.; Acar, J. Incidence of patulin in apple juice concentrates produced in Turkey. J. Chromatogr. A. 1998, 815, 99-102.
3. Kitabatake, N.; Doi, E.; Trivedi, A. B. Toxicity evaluation of the mycotoxins, citrinin and ochratoxin A, using several animal cell lines. Comp. Biochem. Physiol. 1993, 105, 429-433.
4. Kogika, M. M.; Hagiwara, M. K.; Mirandola, R. M. Experimental citrinin nephrotoxicosis in dogs: renal function evaluation. Vet. Hum. Toxicol 1993, 35, 136-140.
5. Lockard, V. G.; Phillips, R. D.; Hayes, A. W.; Berndt, W. O.; O'Neal, R. M. Citrinin nephrotoxicity in rats: a light and electron microscopic study. Exp. Mol. Pathol. 1980, 32, 226-40.
6. Aleo, M. D.; Wyatt, R. D.; Schnellmann, R. G. The role of altered mitochondrial function in citrinin-induced toxicity to rat renal proximal tubule suspensions. Toxicol. Appl. Pharmacol. 1991, 109, 455-463.
7. Chagas, G. M.; Campello, A. P.; Kluppel, M. L. Mechanism of citrinin-induced dysfunction of mitochondria. I. Effects on respiration, enzyme activities and membrane potential of renal cortical mitochondria. J. Appl. Toxicol. 1992, 12, 123-129.
8. 2+ transport. Cell Biochem. Funct. 1995, 13, 53-59.
9. Ribeiro, S. M. R.; Chagas, G. M.; Campello, A. P.; Kluppel, M. L. W.; Mechanism of citrinin-induced dysfunction of mitochondria. V. Effect on the homeostasis of the reactive oxygen species. Cell Biochem. Funct. 1997, 15, 203-209.
10. Jeswal, P. Citrinin-induced chromosomal abnormalities in the bone marrow cells of Mus musculus. Cytobios 1996, 86, 29-33.
11. Pfeiffer, E.; Grob, K.; Metzler, M. Aneuploidogenic and clastogenic potential of the mycotoxins citrinin and patulin. Carcinogenesis 1998, 19, 1313-1318.
12. Arai, M.; Hibino, T. Tumorigenecity of citrinin in male F344 rats. Cancer Lett. 1983, 17, 281-287.
13. Liu, B. H.; Yu, F. Y.; Wu, T. S.; Li, S. Y.; Su, M. C.; Wang, M. C.; Shih, S. M. Evaluation of genotoxic risk and oxidative DNA damage in mammalian cells exposed to mycotoxins, patulin and citrinin. Toxicol. Appl. Pharmacol. 2003, 191, 255-263.
14. Thust, R.; Kneist, S.; Mendel, J. Patulin, a further clastogenic mycotoxin, is negative in the SCE assay in Chinese hamster V79-E cells in vitro. Mutat. Res. 1982, 103, 91-97.
15. Fabre, C. E.; Santerre, A. L.; Loret, M. O.; Baberian, R.; Pareilleux, A.; Goma, G.; Blanc, P. J. Production and food applications of the red pigments of Monascus rubber. J. Food Sci. 1993, 58, 1099-1110.
16. Lin, C. F. Isolation, and cultural conditions of Monascus sp. for the production of pigment in a submerged culture. J. Ferment. Technol. 1973, 51, 407-414.
17. Aniya, Y.; Yokomakura, T.; Yonamine, M.; Shimada, K.; Nagamine, T.; Shimabukuro, M.; Gibo, H. Screening of antioxidant action of various molds and protection of Monascus anka against experimentally induced liver injuries of rats. Gen. Pharmacol. 1999, 32, 225-231.
18. Aniya, Y.; Ohtani, I. I.; Higa, T.; Miyagi, C.; Gibo, H.; Shimabukuro, M.; Nakanishi, H.; Taira, J. Dimerumic acid as an antioxidant of the mold, Monascus anka. Free Radical Biol. Med. 2000, 28, 999-1004.
19. Ma, J.; Li, Y.; Ye, Q.; Li, J.; Hua, Y.; Ju, D.; Zhang, D.; Cooper, R.; Chang, M. Constituents of red yeast rice, a traditional Chinese food and medicine. J. Agric. Food Chem. 2000, 48, 5220-5225.
20. Su, Y. C.; Wang, J. J.; Lin, T. T.; Pan, T. M. Production of the secondary metabolites gamma-aminobutyric acid and monacolin K by Monascus. J. Ind. Microbiol. Biotechnol. 2003, 30, 41-46.
21. Endo, A.; Hasum, K. Biochemical aspect of HMG CoA reductase inhibitors. Adv. Enzymol. Regul. 1989, 28, 53-64.
22. Man, R. Y.; Lynn, E. G.; Cheung, F.; Tsang, P. S. O K. Cholestin inhibits cholesterol synthesis and secretion in hepatic cells (HepG2). Mol. Cell. Biochem. 2002, 233, 153-158.
23. Hayakawa, K.; Kimura, M.; Kamata, K. Mechanism underlying γy-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats. Eur. J. Pharmacol. 2002, 438, 107-113.
24. Hsieh, P. S.; Tai, Y. H. Aqueous extract of Monascus purpureus M9011 prevents and reverses fructose-induced hypertension in rats. J. Agric. Food Chem. 2003, 51, 3945-3950.
25. Yasukawa, K.; Takahashi, M.; Natori, S.; Kawai, K.; Yamazaki, M.; Takeuchi, M.; Takido, M. Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice. Oncology 1994, 51, 108-112.
26. Yasukawa, K.; Takahashi, M.; Yamanouchi, S.; Takido, M. Inhibitory effect of oral administration of Monascus pigment on tumor promotion in two-stage carcinogenesis in mouse skin. Oncology 1996, 53, 247-249.
27. Heber, D.; Yip, I.; Ashley, J. M.; Elashoff, D. A.; Elashoff, R. M.; Go, V. L. W. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am. J. Clin. Nutr. 1999, 69, 231-236.
28. Li, C.; Zhu, Y.; Wang, Y. Monascus purpureus-fermented rice (red yeast rice): a natural food product that lowers blood cholesterol in animal models of hypercholesterolemia. Nutr. Res. 1998, 18, 71-81.
29. Wang, J.; Lu, Z.; Chi, J. Multicenter clinical trial of the serum lipid-lowering effects of a Monascus purpureus (red yeast) rice preparation from traditional Chinese medicine. Curr. Ther. Res. 1997, 58, 964-977.
30. Wei, W.; Li, C.; Wang, Y.; Su, H.; Zhu, J.; Kritchevsky, D. Hypolipidemic and anti-atherogenic effects of long-term Cholestin (Monascus purpureus-fermented rice, red yeast rice) in cholesterol fed rabbits. J. Nutr. Biochem. 2003, 14, 314-318.
31. Blanc, P. J.; Laussac, J. P.; Le Bars, J.; Le Bars, P.; Loret, M. O.; Pareilleux, A.; Prome, D.; Prome, J. C.; Santerre, A. L.; Goma, G. Characterization of monascidin A from Monascus as a citrinin. Int. J. Food Microbiol 1995, 27, 201-213.
32. Blanc, P. J.; Loret, M. O.; Goma, G. Production of citrinin by various species of Monascus. Biotechnol. Lett. 1995, 17, 291-294.
33. Sabater, V. M.; Maas, R. F. M.; Fink, G. J. Mutagenicity of commercial Monascus fermentation products and the role of citrinin contamination. Mutat. Res. 1999, 444, 7-16.
34. Marti, L. R.; Wilson, D. M.; Evans, B. D. Determination of citrinin in corn and barley. J. AOAC Int. 1978, 61, 1353-1358.
35. Cabaud, P. G.; Wroblewski, F. A colorimetric measurement of lactic dehydrogenase activity of body fluids. Am. J. Clin. Pathol. 1958, 30, 234.
36. Carmichael, J.; Degraff, W. G.; Gazdar, A. F.; Minna, J. D.; Mitchell, J. B. Evaluation of a tetrazolium-based semiautomated colorimetric assay; assessment of radiosensitivity. Cancer Res. 1987, 47, 943-946.
37. Heber, D.; Lembertas, A.; Lu, Q. Y.; Bowerman, S.; Go, V. L. An analysis of nine proprietary Chinese red yeast rice dietary supplements: implications of variability in chemical profile and content. J. Altern. Complem. Med. 2001, 7, 133-139.
38. Pan, Zm.; Wigger-alberti, W.; Bauer, A.; Hipler, U. C.; Elsner, P. Anaphylaxis due to Monascus purpureus-femented rice (red yeast rice). Allergy 1999, 54, 1330-1331.
39. 1) on growth of brewing yeasts. J. Appl. Microbiol. 2000, 88, 388-403.
40. Huff, W. E.; Harvey, R. B.; Kubena, L. F.; Rottinghaus, G. E. Toxic synergism between aflatoxin and T-2 toxin in broiler chickens. Poult. Sci. 1988, 67, 1418-1423.
41. Ueno, Y.; Yabe, T.; Hashimoto, H.; Sekijima, M.; Masuda, T.; Kim, D. J.; Hasegawa, R.; Ito, N. Enhancement of GST-P-positive liver cell foci development by nivalenol, a trichothecene mycotoxin. Carcinogenesis 1992, 13, 787-791.