Endometrial adenocarcinoma associated with subtle lymph-vascular space invasion and lymph node metastasis: A histologic pattern mimicking intravascular and sinusoidal histiocytes

International Journal of Gynecological Pathology

Volumn 24, Issue 1, 2005, Pages 73-78

  McKenney, Jesse K ^a   Kong, Christina S ^a   Longacre, Teri A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenocarcinoma; Endometrium; Invasion; Lymph node; Lymph vascular; Metastasis; Staging

Indexed keywords

ABDOMINAL HYSTERECTOMY; ADULT; AGED; ARTICLE; CANCER INVASION; CANCER RADIOTHERAPY; CASE REPORT; CELL INFILTRATION; CELL STRUCTURE; ENDOMETRIUM CARCINOMA; FEMALE; HISTIOCYTE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; PATHOLOGICAL ANATOMY; PRIORITY JOURNAL; PROGNOSIS; SALPINGOOOPHORECTOMY;

AGED; CARCINOMA, ENDOMETRIOID; ENDOMETRIAL NEOPLASMS; FEMALE; HISTIOCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; KERATINS; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; TREATMENT OUTCOME;

EID: 11244311718     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pgp.0000148340.62017.e3     Document Type: Article

References (34)

1. Ambros RA, Kurman RJ. Identification of patients with stage I uterine endometrioid adenocarcinoma at high risk of recurrence by DNA ploidy, myometrial invasion, and vascular invasion. Gynecol Oncol 1992;45:235-9.
2. Ambros RA, Kurman RJ. Combined assessment of vascular and myometrial invasion as a model to predict prognosis in stage I endometrioid adenocarcinoma of the uterine corpus. Cancer 1992;69: 1424-31.
3. Ayhan A, Tuncer ZS, Tuncer R, et al. Risk factors for recurrence in clinically early endometrial carcinoma: An analysis of 183 consecutive cases. Eur J Obstet Gynecol Reprod Biol 1994;57: 167-70.
4. Hanson MB, van Nagell JR Jr, Powell DE, et al. The prognostic significance of lymph-vascular space invasion in stage I endometrial cancer. Cancer 1985;55:1753-7.
5. Inoue Y, Obata K, Abe K, et al. The prognostic significance of vascular invasion by endometrial carcinoma. Cancer 1996;78: 1447-51.
6. Sivridis E, Buckley C, Fox H. The prognostic significance of lymphatic vascular space invasion in endometrial adenocarcinoma. Br J Obstet Gynaecol 1987;94:991-4.
7. Tsuruchi N, Kaku T, Kamura T, et al. The prognostic significance of lymphovascular space invasion in endometrial cancer when conventional hematoxylin and eosin staining is compared to immunohistochemical staining. Gynecol Oncol 1995;57:307-12.
8. Yamazawa K, Seki K, Matsui H, et al. Significance of perivascular lymphocytic infiltrates in endometrial carcinoma. Cancer 2001;91: 1777-84.
9. Lee KR, Vacek PM, Belinson JL. Traditional and nontraditional histopathologic predictors of recurrence in uterine endometrioid adenocarcinoma. Gynecol Oncol 1994;54:10-8.
10. Bell J, Minnick A, Reid G, et al. Relationship of nonstaging pathologic risk factors to lymph node metastasis and recurrence in clinical stage 1 endometrial carcinoma. Gynecol Oncol 1997;66: 388-92.
11. Gal D, Recio F, Zamurovic D, et al. Lymphvascular space involvement: A prognostic indicator in endometrial adenocarcinoma. Gynecol Oncol 1991;42:142-45.
12. Morrow C, Bundy B, Kurman R, et al. Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: A gynecologic oncology group study. Gynecol Oncol 1991;40:55-65.
13. Tornos C, Silva E, El-Naggar A, et al. Aggressive stage I grade 1 endometrial carcinoma. Cancer 1992;70:790-98.
14. Mariani A, Webb M, Keeney G, et al. Predictors of lymphatic failure in endometrial cancer. Gynecol Oncol 2002;84:437-42.
15. Cohn DE, Horowitz NS, Mutch DG, et al. Should the presence of lymphvascular space involvement be used to assign patients to adjuvant therapy following hysterectomy for unstaged endometrial cancer? Gynecol Oncol 2002;87:243-6.
16. Zaino RJ. Lymph-vascular space invasion in endometrial adenocarcinoma: confusion, confessions, and conclusions. Gynecol Oncol 2002;87:240-2.
17. Murray SK, Young RH, Scully RE. Unusual epithelial and stromal changes in myoinvasive endometrioid adenocarcinoma: Study of their frequency, associated diagnostic problems, and prognostic significance. Int J Gynecol Pathol 2003;22:324-33.
18. Mittal K, Barwick K. Diffusely infiltrating adenocarcinoma of the endometrium: A subtype with poor prognosis. Am J Surg Pathol 1988;12:754-8.
19. Longacre T, Hendrickson M. Diffusely infiltrative endometrial adenocarcinoma: An adenoma malignum pattern of myoinvasion. Am J Surg Pathol 1999;23:69-78.
20. Announcement. FIGO Stages: 1988 Revision. Gynecol Oncol 1989; 35:125-6.
21. Longacre TA, Chung MH, Jensen DN, et al. Proposed criteria for the diagnosis of well-differentiated endometrial carcinoma: A diagnostic test for myoinvasion. Am J Surg Pathol 1995;19: 371-406.
22. Alexander-Sefre F, Singh N, Ayhan A, et al. Detection of tumour lymphovascular space invasion using dual cytokeratin and CD31 immunohistochemistry. J Clin Pathol 2003;56:786-8.
23. Alexander-Sefre F, Singh N, Ayhan A, et al. Clinical value of immunohistochemically detected lymphovascular invasion in endometrioid endometrial cancer. Gynecol Oncol 2004;92:653-9.
24. Greene FL, Page DL, Fleming ID, et al., eds. AJCC Cancer Staging Manual. 6th ed. New York: Springer. 1997:223-40.
25. Fishman A, Klein A, Zemer R, et al. Detection of micrometastasis by cytokeratin-20 (reverse transcription polymerase chain reaction) in lymph nodes of patients with endometrial cancer. Gynecol Oncol 2000;77:399-404.
26. Juretzka MM, Jensen KC, Longacre TA, et al. Detection of pelvic lymph node micrometastasis in stage IA2-IB2 cervical cancer by immunohistochemical analysis. Gynecol Oncol 2004;93:107-11.
27. Lentz SE, Muderspach LI, Felix JC, et al. Identification of micrometastases in histologically negative lymph nodes of early-stage cervical cancer patients. Obstet Gynecol 2004;103:1204-10.
28. Hakam A, Nasir A, Raghuwanshi R, et al. Value of multilevel sectioning for improved detection of micrometastases in sentinel lymph nodes in invasive squamous cell carcinoma of the vulva. Anticancer Res 2004;24:1281-6.
29. Moore RG, Granai CO, Gajewski W, et al. Pathologic evaluation of inguinal sentinel lymph nodes in vulvar cancer patients: A comparison of immunohistochemical staining versus ultrastaging with hematoxylin and eosin staining. Gynecol Oncol 2003;91:378-82.
30. Yabushita H, Shimazu M, Yamada H, et al. Occult lymph node metastases detected by cytokeratin immunohistochemistry predict recurrence in node-negative endometrial cancer. Gynecol Oncol 2001;80:139-44.
31. Gonzalez Bosquet J, Keeney GL, Mariani A, et al. Cytokeratin staining of resected lymph nodes may improve the sensitivity of surgical staging for endometrial cancer. Gynecol Oncol 2003;91: 518-25.
32. Argani P, Rosai J. Hyperplastic mesothelial cells in lymph nodes: Report of six cases of a benign process that can simulate metastatic involvement by mesothelioma or carcinoma. Hum Pathol 1998;29: 339-46.
33. Clement P, Young R, Oliva E, et al. Hyperplastic mesothelial cells within abdominal lymph nodes: Mimic of metastatic ovarian carcinoma and serous borderline tumor: A report of two cases associated with ovarian neoplasms. Mod Pathol 1996;9:879-86.
34. Gould VE, Bloom KJ, Franke WW, et al. Increased numbers of cytokeratin-positive interstitial reticulum cells (CIRC) in reactive, inflammatory and neoplastic lymphadenopathies: Hyperplasia or induced expression? Virchows Arch 1995;425:617-29.