Hydroamination/Heck reaction sequence for a highly regioselective one-pot synthesis of indoles using 2-chloroaniline

Chemical Communications

Volumn , Issue 24, 2004, Pages 2824-2825

  Ackermann, Lutz ^a   Kaspar, Ludwig T ^a   Gschrei, Christian J ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLOROANILINE; ANILINE DERIVATIVE; IMIDAZOL 2 YLIDENE PALLADIUM COMPLEX; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; PALLADIUM; THALLIUM CHLORIDE; THALLIUM CHLORIDE TL 201; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; COMPLEX FORMATION; CYCLIZATION; HECK REACTION; HYDROAMINATION; ONE POT SYNTHESIS; STEREOCHEMISTRY; STEREOSPECIFICITY; SYNTHESIS;

EID: 11244303542     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b411571f     Document Type: Article

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25. The activity of phosphine derived complexes was not studied.
26. Note that 4 is commercially available from Strem.
27. The connectivity of the regioisomers was confirmed via hydrolysis of the hydroamination products and isolation of the corresponding ketones.