Thrombin induces Sp1-mediated antiviral effects in cytomegalovirus-infected human retinal pigment epithelial cells

Medical Microbiology and Immunology

Volumn 193, Issue 4, 2004, Pages 195-203

  Scholz, Martin ^a   Vogel, Jens Uwe ^a   Höver, Gerold ^a   Prösch, Susanna ^b   Kotchetkov, Ruslan ^a   Cinatl, Jaroslav ^c   Koch, Frank ^a   Doerr, Hans Wilhelm ^a   Cinatl Jr , Jindrich ^a  

^a GOETHE UNIVERSITY   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c KLINLAB   (Czech Republic)

Author keywords

Human cytomegalovirus; Infectious immunity virus; Retina; Signal transduction; Transcription factors

Indexed keywords

ACETIC ACID DERIVATIVE; DNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; TRANSCRIPTION FACTOR SP1;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CELL CULTURE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; EPITHELIUM CELL; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMEDIATE EARLY GENE; IMMEDIATE LATE GENE; INHIBITION KINETICS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; STIMULATION;

ANTIVIRAL AGENTS; CELLS, CULTURED; CYTOMEGALOVIRUS; GENE EXPRESSION REGULATION, VIRAL; HUMANS; IMMEDIATE-EARLY PROTEINS; PIGMENT EPITHELIUM OF EYE; RECEPTOR, PAR-1; SIGNAL TRANSDUCTION; SP1 TRANSCRIPTION FACTOR; THROMBIN; TRANS-ACTIVATORS; VIRAL PROTEINS; VIRUS ACTIVATION;

EID: 11244252910     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00430-003-0194-x     Document Type: Article

References (51)

1. Heinemann MH (1992) Characteristics of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Am J Med 92:12S-16S
2. Sund F, Wahlberg J, Eriksson BM (2001) CMV disease in CMV-mismatched renal transplant recipients with prophylactic low dose valaciclovir. J Clin Virol 23:107-111
3. Crippa F, Corey L, Chuang EL, Sale G, Boeckh M (2001) Virological, clinical, and ophtalmologie features of cytomegalovirus retinitis after hematopoietic stem cell transplantation. Clin Infect Dis 32:214-219
4. Egbert PR, Pollard RB, Gallagher JG, Merigan TC (1980) Cytomegalovirus retinitis in immunosuppressed hosts. II. Ocular manifestations. Ann Intern Med 93:664-670
5. Pepose JS, Holland GN, Nestor MS, Cochran AJ, Foos RY (1985) Acquired immune deficiency syndrome. Pathogenic mechanisms of ocular disease. Ophthalmology 92:472-484
6. Rao NA, Zhang J, Ishimoto S (1966) Role of retinal vascular endothelial cells in development of CMV retinitis. Trans Am Ophthalmol Soc 96:111-123
7. Cunha-Vaz JG, Shakib M, Ashton N (1966) Studies on the permeability of the blood-retinal barrier. I. On the existence, development, and site of a blood-retinal barrier. Br J Ophtalmol 50:441-453
8. Raviola G, Raviola E (1967) Light and electron microscopic observations on the inner plexiform layer of the rabbit retina. Am J Anat 120:403-425
9. Vinores SA, Derevjanik NL, Ozaki H, Okamoto N, Campochiaro PA (1999) Cellular mechanisms of blood-retinal barrier dysfunction in macular edema. Doc Ophthalmol 97:217-228
10. Holtkamp GM, Kijlstra A, Peek R, Vos AF de (2001) Retinal pigment epithelium-immune system interactions: cytokine production and cytokine-induced changes. Prog Retin Eye Res 20:29-48
11. Wenkel H, Streilein JW (2000) Evidence that retinal pigment epithelium functions as an immune-privileged tissue. Invest Ophthalmol Vis Sci 41:3467-3473
12. Cinatl J Jr, Blaheta R, Bittoova M, Scholz M, Margraf S, Vogel JU, Cinatl J, Doerr HW (2000) Decreased neutrophil adhesion to human cytomegalovirus- infected retinal pigment epithelial cells is mediated by virus-induced up-regulation of Fas ligand independent of neutrophil apoptosis. J Immunol 165:4405-4413
13. Cinatl J Jr, Margraf S, Vogel J-U, Scholz M, Cinatl J, Doerr HW (2001) Human cytomegalovirus circumvents NF-κB dependence in retinal pigment epithelial cells J Immunol 167:1900-1908
14. Scholz M, Margraf S, Menon S, Schuller A, Doerr HW, Cinatl J (2003) Supernatants from human cytomegalovirus (HCMV)-infected retinal glial cells increase transepithelial electrical resistance in a cell culture model: evidence of HCMV immune escape in the eye? Med Microbiol Immunol (in press)
15. Pecorella I, Ciardi A, Garner A, McCartney AC, Lucas S (2000) Postmortem histological survey of the ocular lesions in a British population of AIDS patients. Br J Ophtalmol 84:1275-1281
16. Sakamoto T, Sakamoto H, Sheu SJ, Gabrielian K, Ryan SJ, Hinton DR (1994) Intercellular gap formation in confluent cultured bovine retinal pigment epithelial cells. Invest Ophtalmol Vis Sci 35:720-729
17. Iijima H, Gohdo T, Imai M, Tsukahara S (1998) Thrombin-antithrombin III complex in retinal vein occlusion. Am J Ophtalmol 126:677-682
18. Sagripanti A, Romani A, Ferretti A, et al (1999) Blood coagulation parameters in retinal arterial occlusion. Graefe's Arch Clin Exp Ophtalmol 237:480-483
19. Sutherland MR, Raynor CM, Leenknegt H, Wright JF, Pryzdial EL (1997) Coagulation initiated on herpes viruses. Proc Natl Acad Sci USA 94:13510-13514
20. Pryzdial EL, Wright JF (1994) Prothrombinase assembly on an enveloped virus: evidence that the cytomegalovirus surface contains procoagulant phospholipid. Blood 84:3749-3757
21. Guetta E, Scarpati EM, DiCorleto PE (2001) Effect of cytomegalovirus immediate early gene products on endothelial cell gene activity. Cardiovasc Res 50:538-546
22. Marin V, Farnarier C, Grès S, Kaplanski S, Su MS, Dinarello CA, Kaplanski G (2001) The p38 mitogen-activated protein kinase plays a critical role in thrombin-induced endothelial chemokine production and leucocyte recruitment. Blood 98:667-673
23. Li Q-J, Vaingankar S, Sladek FM, Martins-Green M (2000) Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression. Blood 96:3696-3706
24. Vu TK, Hung DT, Wheaton VI, Coughlin SR (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057-1068
25. Patterson C, Stouffer GA, Madamanchi N, Runge MS (2001) New tricks for old dogs. Nonthrombotic effects of thrombin in vessel wall biology. Circ Res 88:987-997
26. Scholz M, Doerr HW, Cinatl J Jr (2001) Inhibition of cytomegalovirus immediate early gene expression: a therapeutic option? Antiviral Res 49:129-145
27. Castillo JP, Kowalik TF (2002). Human cytomegalovirus immediate early proteins and cell growth control. Gene 290:19-34
28. Cherrington JM, Mocarski ES (1989) Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element. J Virol 63:1435-1440
29. Sambucetti LC, Cherrington JM, Wilkinson GW, Mocarski ES (1989) NF-κB activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation. EMBO J 8:4251-4258
30. Yurochko AD, Mayo MW, Poma EE, Baldwin AS Jr, Huang ES (1997) Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-κB promoters. J Virol 71:4638-4648
31. Speir E, Yu ZX, Takeda K, Ferrans VJ, Cannon RO 3rd (2000) Antioxidant effect of estrogen on cytomegalovirus-induced gene expression in coronary artery smooth muscle cells. Circulation 102:2990-2996
32. Cinatl J Jr, Cinatl J, Weber B, Rabenau H, Gumbel HO, Chenot JF, Scholz M, Encke A, Doerr HW (1995) In vitro inhibition of human cytomegalovirus replication in human foreskin fibroblasts and endothelial cells by ascorbic acid 2-phosphate. Antiviral Res 27:405-418
33. Cinatl J Jr, Kotchetkov R, Schulz M, Cinatl J, Vogel JU, Driever PH, Doerr HW (1999) Human cytomegalovirus infection decreases expression of thrombospondin-1 independent of the tumor suppressor protein p53. Am J Pathol 155:285-292
34. Tone M, Tone Y, Babik JM, Lin CY, Waldmann H (2002) The role of Sp1 and NF-κB in regulating CD40 gene expression. J Biol Chem 277:8890-8897
35. Green DR, Ferguson TA (2001) The role of Fas ligand in immune privilege. Nat Rev Mol Cell Biol 2:917-924
36. Yang Z, Cohen RL, Lui GM, Lawrence DA, Shuman MA (1995) Thrombin increases expression of urokinase receptor by activation of the thrombin receptor. Invest Ophtalmol Vis Sci 36:2254-2261
37. O'Brien PJ, Molino M, Kahn M, Brass LF (2001) Protease activated receptors: theme and variations. Oncogene 20: 1570-1581
38. Prösch S, Staak K, Stein J, Liebenthal C, Stamminger T, Volk HD, Kruger DH (1995) Stimulation of human cytomegalovirus IE enhancer/promoter in HL-60 cells by TNFα is mediated via induction of NF-κB. Virology 208:197-206
39. Stein J, Volk HD, Liebenthal C, Krüger DH, Prösch S (1993) Tumor necrosis factor alpha stimulates the activity of the human cytomegalovirus major immediate early enhancer/promoter in immature monocytic cells. J Gen Virol 74:2333-2338
40. Prösch S, Heine AK, Volk HD, Krüger DH (2001) CCAAT/ enhancer-binding proteins alpha and beta negatively influence the capacity of tumor necrosis factor alpha to up-regulate the human cytomegalovirus IE1/2 enhancer/promoter by nuclear factor kappaB during monocyte differentiation. J Biol Chem 276:40712-40720
41. Mondino BJ, Sidikaro Y, Mayer FJ, Sumner H (1990) Inflammatory mediators in the vitreous humor of AIDS patients with retinitis. Invest Ophthalmol Vis Sci 31:798-804
42. Bodaghi B, Goureau O, Zipeto D, Laurent L, Virelizier JL, Michelson S (1999) Role of IFN-gamma-induced indoleamine 2,3 dioxygenäse and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells. J Immunol 162:957-964
43. Dool-Bboon K, DeLuca NA (2002) Phosphorylation of transcription factor Sp1 during herpes simplex virus type 1 infection. J Virol 76:6473-6479
44. Rohlff C, Ahmad S, Borellini F, Lei J, Glazer RI (1997) Modulation of transcription factor Sp1 by cAMP-dependent protein kinase. J Biol Chem 272:21137-21141
45. Leggett RW, Armstrong SA, Barry D, Mueller CR (1995) Sp1 is phosphorylated and its DNA binding activity down-regulated upon terminal differentiation of the liver. J Biol Chem 270:25879-25884
46. Lacroix I, Lipcey C, Imbert J, Kahn-Perles B (2002) Sp1 transcriptional activity is up-regulated by phosphatase 2A in dividing T lymphocytes. J Biol Chem 277:9598-9605
47. Gardner A, Phillips-Mason PJ, Raben DM, Baldassare JJ (2002) A novel role for Gq alpha in alpha-thrombin-mediated mitogenic signalling pathways. Cell Signal 14:499-507
48. Fortunato EA, Sanchez V, Yen JY, Spector DH (2002) Infection of cells with human cytomegalovirus during s phase results in a blockade to immediate-early gene expression that can be overcome by inhibition of the proteasome. J Virol 76:5369-5379
49. Scholz M, Doerr HW, Cinatl J (2003) Human cytomegalovirus retinitis: pathogenicity, immune evasion and persistence. Trends Microbiol. 11:171-178
50. Yoshida A, Elner SG, Bian ZM, Kunkel SL, Lukacs NW, Elner VM (2001) Thrombin regulates chemokine induction during human retinal pigment epithelial cell/monocyte interaction. Am J Pathol 159:1171-1180
51. Mann MJ, Dzau VJ (2000) Therapeutic applications of transcription factor decoy oligonucleotides. J Clin Invest 106:1071-1075