Polymer beads in biomedical chromatography: Preparation and characterization

Colloidal Polymers: Synthesis and Characterization

Volumn , Issue , 2003, Pages 319-349

  Tuncel, Ali ^a   Ünsal, Ender ^a   Şenel, Serap ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 11144340672     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9780203911488-12     Document Type: Chapter

References (49)

1. Mueller, K.F.; Heiber, S.J.; Pianki. W.L. Hydrogels as Large Size Spherical Beads. US Patent 4,224,427, 1981.
2. Kahovec, J.; Coupek, J. Chemical modification of macroreticular 2-hydroxyethyl-methacrylate copolymers. React. Polym. 1988, 8, 105-11 1.
3. Horak, D.; Lednicky, F.; Rehak, V.; Svec, F. Porous polyHEMA beads prepared bysuspension polymerization in aqueous medium. J. Appi. Polym. Sci. 1993, 49, 2041-2050.
4. Horak, D.; Lednicky, F.; Bleha, Μ. Effect of inert components on the porous structure of 2-hydroxyethylmethacrylate ethylene dimethacrylate copolymers. Polymer 1996, 37, 4243-4249.
5. Horak, D.; Svec, F.; Tennikova, T.B.; Nahunek, Μ. Chromatographic properties of macroporous beads from poly(GMA-co-EDMA). Die Angew. Macromol. Chem. 1992, 195, 139-150.
6. Horak, D.; Labsky, J.; Pilar, J.; Bleha, Μ.; Pelzbauer, Z.; Svec, F. The effect of polymeric porogen on the properties of macroporous polytglycidyl methacrylate-co-ethyleneglycol dimethacrylate). Polymer 1993, 34, 3481-3489.
7. Horak, D.; Straka, J.; Schneider, B.; Lednicky, F.; Pilar, J. Polyethylene dimethacrylate) particles with polyfglycidyl methacrylate) functionalities. Polymer 1994, 35, 1195-1202.
8. Kesenci, K.; Tuncel, A.; Piskin, E. Swellable ethylene glycol dimethacrylatehydroxyethylmethacrylate copolymer beads. React. Funct. Polym. 1996, 31, 137-147.
9. Tuncel, A.; Çiçek, H. 2-Hydroxypropylmethacrylate based mono and bifunctional gel beads prepared by suspension polymerization. Polym. Int. 2000, 49, 485-494.
10. Tuncel, A. Suspension polymerization of polyethyleneglycol methacrylate: a route for spherical swellable gel beads with controlled hydrophilicity and functionality. Colloid Polym. Sci. 2000, 278, 1126-1138.
11. Tuncel, A.; Ecevit, K.; Kesenci, K.; Piskin, E. Nonswellable and swellable ethyleneglycoldimethacrylate-acrylic acid copolymer microspheres. J. Polym. Sci. A Polym. Chem. Ed. 1996, 34, 45-55.
12. Chou, L.Y.; Blanch, H.W.; Praunitz, J. Μ. J. Appi. Polym. Sci. 1992, 45, 14111418.
13. Aoki, T.; Nagao, Y.; Sanui, K.; Ogata, N.; Kikuchi, A.; Sakurai, Y.; Kataoka, K.; Okano, T. Polym. J. 1996, 28, 371-375.
14. Tuncel, A.; Unsal, E.; Cicek, H. pH-sensitive uniform gel beads for DNA adsorption. J. Appi. Polym. Sci. 2000, 77, 3154-3161.
15. Barret, K.E.J., Ed. Dispersion Polymerization in Organic Media. Wiley: London, 1975.
16. Paine, A.J.; Luymes, W.; McNulty, J. Macromolecules 1990, 23, 3104-3108.
17. Ober, C.K.; Lok, K.P.; Hair, M.L. J. Polym. Sci. Polym. Lett. Ed. 1985, 23, 103-112.
18. Shen, S.; Sudol, E.D.; El-Aasser, M.S. J. Polym. Sci. Polym. Chem. Ed. 1994, 32, 1087-1096.
19. Tuncel, A.; Kahraman, R.; Piskin, E. Monosize microbeads by dispersion polymerization of styrene. J. Appi. Polym. Sci. 1993, 50, 303-319.
20. Tuncel, A.; Kahraman, R.; Piskin, E. Monosize polystyrene latices carrying functional groups on their surfaces. J. Appi. Polym. Sci. 1994, 51, 1485-1498.
21. Horak, D.; Shapoval, P. Reactive poly(glycidyl methacrylate) microspheres prepared by dispersion polymerization. J. Polym. Sci. A Polym. Chem. Ed. 2000, 38, 3855-3863.
22. Margel, S.; Nov, E.; Fisher, I. Dispersion polymerization of chloromethylstyrene. J. Polym. Sci. A Polym. Chem. Ed. 1991, 29, 347-352.
23. Li, W.H.; Li, K.; Stover, H.D.H. Monodisperse poly(chloromethylstyrene-co-divinylbenzene) microspheres by precipitation polymerization. J. Polym. Sci. A Polym. Chem. Ed. 1999, 37, 2295-2303.
24. Bahar, T.; Tuncel, A. Monodisperse poly(p-chloromethylstyrene) microbeads by dispersion polymerization. Polym. Eng. Sci. 1999, 39, 1849-1855.
25. Li, W.H.; Stover, H.D.H. Porous monodisperse poly(divinylbenzene) microspheres by precipitation polymerization. J. Polym. Sci. A Polym. Chem. Ed. 1998, 36, 1543-1551.
26. Horak, D.; Krystufek, Μ.; Spevacek, J. J. Polym. Sci. A Polym. Chem. Ed. 2000, 38, 653-663.
27. Horak, D. Effect of reaction parameters on the particle size in the dispersion polymerization of 2-hydroxyethylmethacrylate. J. Polym. Sci. A Polym. Chem. Ed. 1999, 37, 3785-3792.
28. Duracher, D.; Elaissari, A.; Pichot, C. J. Polym. Sci. A Polym. Chem. Ed. 1999, 37, 1823-1837.
29. Ellingsen, T.; Aune, O.; Ugelstad, J.; Hagen, S. Monosized stationary phases for chromatography. J. Chromatogr. 1990, 535, 147-161.
30. Galia, Μ.; Svec, F.; Frechet, J.M.J. Monodisperse polymer beads as packing material for high performance liquid chromatography: effect of divinylbenzene content on the porous and chromatographic properties of poly(styrene-co-divinylbenzene)-beads prepared in the presence of linear polystyrene as a porogen. J. Polym. Sci. A Polym. Chem. Ed. 1994, 32, 2169-2175.
31. Wang, Q.C.; Svec, F.; Frechet, J.M.J. Fine control of the porous structure and chromatographic properties of monodisperse macroporous poly(styrene-co-divinyl-benzene) beads prepared by using polymer porogens. J. Polym. Sci. A Polym. Chem. Ed. 1994, 32, 2577-2588.
32. Cheng, C.M.; Micale, F.J.; Vanderhoff, J.W.; El-Aasser, M.S. Synthesis and characterization of monodisperse porous polymer particles. J. Polym. Sci. A Polym. Chem. Ed. 1992, 30, 235-244.
33. Cheng, C.M.; Vanderhoff, J.W.; El-Aasser, M.S. Monodisperse porous polymer particles: formation of the porous structure. J. Polym. Sci. A Polym. Chem. Ed. 1992, 30, 245-256.
34. Omi, S.; Katami, K.; Yamamoto, A.; Iso, Μ. Synthesis of polymeric microspheres employing SPG emulsification technique. J. Appi. Polym. Sci. 1994, 51, 1-11.
35. Omi, SqKaneko, K.; Nakayama, A.; Katami, K.; Taguchi, T.; Iso, Μ.; Ma, G.H. Application of porous microspheres prepared by SPG emulsification as immobilizing carriers of glucoamylase. J. Appi. Polym. Sci. 1997, 65, 2655-2664.
36. Omi, S. Preparation of monodisperse microspheres using shirasu porous glass emulsification technique. Colloids Surf. A Physicochem. Eng. Asp. 1996, 109, 97107.
37. Smigol, V.; Svec, F. Preparation and properties of uniform beads based on macro-porous glycidylmethacrylate-ethylene dimethacrylate copolymer: use of chain transfer agent for control of the pore size distribution. J. Appi. Polym. Sci. 1993, 48, 2033-2039.
38. Horak, D.; Smigol, V.; Labsky, J.; Svec, F.; Pilar, J. An epr study of the effect of suspension polymerization conditions on the properties of glycidylmethacrylate-ethylene dimethacrylate beads. Polymer 1992, 33, 2051-2056.
39. Smigol, V.; Svec, F. Synthesis and properties of uniform beads based on macropo-rous copolymer glycidyl methacrylate-ethylene dimethacrylate: a way to improve separation media for HPLC. J. Appi. Polym. Sci. 1992, 46, 1439-1448.
40. Smigol, V.; Svec, F.; Frechet, J.M.J. High performance liquid chromatography of complex mixtures using monodisperse-dual chemistry polymer beads prepared by a pore-size specific functionalization process. Anal. Chem. 1994, 66, 2129-2138.
41. Smigol, V.; Svec, F.; Frechet, J.M.J. Two-dimensional high performance liquid chromatography using monodisperse polymer beads containing segregated chemistries prepared by pore size specific functionalization. Single column combinations of size exclusion or ion exchange with reversed phase chromatography. Anal. Chem. 1994, 66, 4308-4315.
42. Petro, Μ.; Svec, F; Frechet, J.M.J. Monodisperse hydrolysed poly(glycidyl meth-acrylate-co-ethylene dimethacrylate) beads as a stationary phase for normal phase HPLC. Anal. Chem. 1997, 69, 3131-3139.
43. Lewandowski, K.; Svec, F.; Frechet, J.M.J. Polar monodisperse, reactive beads from functionalized methacrylate monomers by staged templated suspension polymerization. Chem. Mater. 1998, 10, 385-391.
44. Li, W.H.; Stover, H.D.H. Monodisperse crosslinked core-shell microspheres by precipitation polymerization. Macromolecules 2000, 33, 4354-4360.
45. Tuncel, A.; Tuncel, Μ.; Salih, B. Electron microscopic observation of uniform macroporous particles. I. Effect of seed latex type and diluent. J. Appi. Polym. Sci. 1999, 71, 2271-2290.
46. Tuncel, A. Electron microscopic observation of uniform macroporous particles. II. Effect of DVB concentration. J. Appi. Polym. Sci. 1999, 71, 2291-2302.
47. Camli, T.; Tuncel, Μ.; Senel, S.; Tuncel, A. Functional, uniform and macroporous latex particles: preparation, electron microscopic characterization and nonspecific protein adsorption properties. J. Appi. Polym. Sci. 2002. 84, 414-429.
48. Tuncel, A.; Tuncel, Μ.; Çiçek, H.; Fidanboy, O. 2-Hydroxyethylmethacrylate carrying uniform, porous particles: preparation and electron microscopy. Polym. Int. 2001, 51, 75-84.
49. Tuncel, A.; Tuncel, Μ.; Ergun, V.; Alagöz, C.; Bahar, T. Carboxyl carrying large uniform latex particles. Colloids Surf. A Physicochem. Eng. Asp. 2002, 197, 79-94.