Antigen epitope density dependent cell surface discrimination and the role of the lipid rafts

Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, METMBS'04

Volumn , Issue , 2004, Pages 429-435

  Nudelman, German ^a   Louzoun, Yoram ^a  

^a BAR ILAN UNIVERSITY   (Israel)

Author keywords

B cell receptor; Cell surface dynamics.; Hapten valence; Lipid Rafts; Monte Carlo method

Indexed keywords

ANTIBODIES; ANTIGENS; COMPUTER SIMULATION; IMMUNOLOGY; LIPIDS; METABOLISM; MONTE CARLO METHODS; SOLUBILITY;

B CELL RECEPTORS; CELL SURFACE DYNAMICS; HAPTEN VALENCE; LIPID RAFTS;

CELLS;

EID: 11144334189     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (7)

1. Cheng PC, Dykstra ML, Mitchell RN, Pierce SK: A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J Exp Med 190:1549-1560, Dec. 1999.
2. Klemm JD, Schreiber SL, Crabtree GR: Dimerization as a regulatory mechanism in signal transduction. Annual Review of Immunology 16:569-592,1998.
3. Cochran JR, Stern LJ: A diverse set of oligomeric class II MHC-peptide complexes for probing T-cell receptor interactions. Chem Biol 7:683-696, Sept. 2000.
4. Dintzis HM, Dintzis RZ, Vogelstein B: Molecular determinants of immunogeniciry: the immunon model of immune response. Proc Natl Acad Sei U S A 73:3671-3675, Oct. 1976.
5. Nudelman G: Cell Surface Dynamics: The balance between aggregation, diffusion and endocytosis. JMGM Submitted, 2003.
6. Dintzis RZ, Okajima M, Middleton MH, Greene G, Dintzis HM: The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence. J Immunol 143:1239-1244, Aug. 1989.
7. Pralle A, Keller P, Florin EL, Simons K, Horber JK: Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. J Cell Biol 148:997-1008, Mar. 2000.