IgA nephropathy and tonsils - An approach from the structure of IgA1 produced by tonsillar lymphocytes

Acta Oto-Laryngologica, Supplement

Volumn 124, Issue 555, 2004, Pages 28-31

  Hiki, Yoshiyuki ^a   Horie, Akeyo ^b   Yasuda, Yoshinari ^b   Iwase, Hitoo ^c   Sugiyama, Satoshi ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

Galactose; Hinge; IgA nephropathy; IgA1; O glycan; Sialic acid

Indexed keywords

GLYCAN; IMMUNOGLOBULIN A1; MUCIN; PEPTIDE; PROLINE; IMMUNOGLOBULIN A; POLYSACCHARIDE;

CONFERENCE PAPER; CONTROLLED STUDY; DISEASE EXACERBATION; GLOMERULUS; GLYCOSYLATION; HUMAN; IMMUNOCOMPETENCE; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOGLOBULIN PRODUCTION; IMMUNOGLOBULIN STRUCTURE; LYMPHOCYTE; PALATINE TONSIL; PRIORITY JOURNAL; TONSIL; UPPER RESPIRATORY TRACT INFECTION; ARTICLE; CHEMISTRY; CHRONIC DISEASE; CONFORMATION; IMMUNOLOGY; METABOLISM; TONSILLITIS;

CARBOHYDRATE CONFORMATION; CHRONIC DISEASE; GLOMERULONEPHRITIS, IGA; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN A; LYMPHOCYTES; POLYSACCHARIDES; TONSIL; TONSILLITIS;

EID: 11144333586     PISSN: 03655237     EISSN: None     Source Type: Journal    
DOI: 10.1080/03655230410003314     Document Type: Conference Paper

References (26)

1. Berger J, Hinglais N. Les depots intercapillaires d'IgA-IgG. J Urol Nephrol 1968; 74: 694-5.
2. Clarkson AR, Woodroffe AJ, Aarons I, Hiki Y, Hale G. IgA nephropathy. Ann Rev Med 1987; 38: 157-68.
3. Conley ME, Cooper MD, Michael AF. Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus. J Clin Invest 1980; 66: 1432-6.
4. Baenziger J, Kornfeld S. Structure of the carbohydrate units of IgA1 immunoglobulin. II. Structure of the O-glycosidically linked oligosaccharide units. J Biol Chem 1974; 249: 7270-81.
5. Mattu TS, Pleass RJ, Willis AC, Lilian M, Wormald MR, Lellouch AC, Rudd PN, Woof JM, Dwek RA. The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc α receptor interactions. J Biol Chem 1998; 273: 2260-72.
6. Cunningham LW. Microheterogeneity and function of glycoproteins. In: Jamieson GA, Greenwalt TJ, editors. Glycoprotein of blood cells and plasma. Philadelphia: JB Lippincott Company; 1971. p. 16-34.
7. Allen AC, Harper SJ, Feehally J. Galactosylation of N- and O-linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy. Clin Exp Immunol 1995; 100: 470-4.
8. Tomana M, Matousovic K, Julian B, Radl J, Konecny K, Mestecky J. Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. Kidney Int 1997; 52: 509-16.
9. Odani H, Hiki Y, Takahashi M, Nishimoto A, Yasuda Y, Iwase H, Shinzato T, Maeda K. Direct evidence for decreased sialylation and galactosylation of human serum IgA1 Fc O-glycosylated hinge peptides in IgA nephropathy by mass spectrometry. Biochem Biophys Res Commun 2000; 271: 268-74.
10. Hiki Y, Odani H, Takahashi M, Yasuda Y, Kobayashi Y, Maeda K. Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy. Kidney Int 2001; 59: 1077-85.
11. Clarkson AR, Seymour AE, Thompson AJ, Haynes WD, Chan YL, Jackson B. IgA nephropathy: a syndrome of uniform morphology, diverse clinical features and uncertain prognosis. Clin Nephrol 1977; 8: 459-71.
12. Bene MC, Hurault de Ligny B, Kessler M, Foliguet B, Faure G. Tonsils in IgA nephropathy. Contrib Nephrol 1993; 104: 153-61.
13. Xie Y, Nishi S, Ueno M, Imai N, Sakatsume M, Narita I, Suzuki Y, Akizawa K, Shimada H, Arakawa M, Gejyo F. The efficacy of tonsillectomy on long-term renal survival in patients with IgA nephropathy. Kidney Int 2003; 63: 1861-7.
14. Bene MC, Faure G, Hurault de Ligny B, Kessler M, Duheille J. Immunoglobulin A nephropathy. Quantitative immunohistomorphometry of the tonsillar plasma cells evidences an inversion of the immunoglobulin A versus immunoglobulin G secreting cell balance. J Clin Inves 1983; 71: 1342-7.
15. Hiki Y, Tanaka A, Kokubo T, Iwase H, Nishikido J, Hotta K, Kobayashi Y. Analyses of IgA1 hinge glycopeptides in IgA nephropathy by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J Am Soc Nephrol 1998; 9: 577-82.
16. Itoh A, Iwase H, Takatani T, Nakamura I, Hayashi M, Oba K, Hiki Y, Kobayashi Y, Okamoto M. Tonsillar IgA1 as a possible source of hypoglycosylated IgA1 in the serum of an IgA nephropathy patient. Nephrol Dial Transplant 2003; 18: 1108-14.
17. D'Amelio R, Palmisano L, Moli SL, Seminara R, Aiuti F. Serum and salivary IgA levels in normal subjects: comparison between tonsillectomized and non-tonsillectomized subject. Int Archs Allergy Appl Immun 1982; 68: 256-9.
18. Mestecky J, Russell MW. IgA subclasses. Monogr Allergy 1986; 19: 277-301.
19. Perry ME. The specialized structure of crypt epithelium in the human palatine tonsil and its functional significance. J Anat 1994; 185: 111-27.
20. Kokubo T, Hiki Y, Iwase H, Tanaka A, Toma K, Hotta K, Kobayashi Y. Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins. J Am Soc Nephrol 1998; 9: 2048-54.
21. Iwase H, Tanaka A, Hiki Y, Kokubo T, Sano T, Ishii-Karakasa I, Toma K, Kobayashi Y, Hotta K. Aggregated human serum immunoglobulin A1 induced by neuraminidase treatment had a lower number of O-linked sugar chains on the hinge portion. J Chromatogr B 1999; 724: 1-7.
22. Hiki Y, Kokubo T, Iwase H, Masaki Y, Sano T, Tanaka A, Toma K, Hotta K, Kobayashi Y. Underglycosylation of IgA1 hinge plays a certain role for its glomerular deposition in IgA nephropathy. J Am Soc Nephrol 1999; 10: 760-9.
23. Sano T, Hiki Y, Kokubo T, Iwase H, Shigematsu H, Kobayashi Y. Enzymatically deglycosylated human IgA1 molecules accumulate and induce inflammatory cell reaction in rat glomeruli. Nephrol Dial Trans 2002; 17: 50-6.
24. Hiki Y, Iwase H, Kokubo T, Horii A, Tanaka A, Nishikido J, Hotta K, Kobayashi Y. Association of asialo-galactosyl β1-37V-acetylgalactosamine on the hinge with a conformational instability of Jacalin-reactive immunoglobulin A1 in immunoglobulin A nephropathy. J Am Soc Nephrol 1996; 7: 955-60.
25. Iwase H, Ohkawa S, Ishii-Karakasa I, Hiki Y, Kokubo T, Sano T, Tanaka A, Toma K, Kobayashi Y, Hotta K. Study of the relationship between sticky human serum IgA1 and its O-glycan glycoform. Biochem Biophys Res Commun 1999; 261: 472-7.
26. Iwase H, Yokozeki Y, Hiki Y, Tanaka A, Kokubo T, Sano T, Ishii-Karakasa I, Hisatani K, Kobayashi Y, Hotta K. Human serum immunoglobulin G3 subclass bound preferentially to asialo-, agalactoimmunoglobulin A1/Sepharose. Biochem Biophys Res Commun 1999; 264: 424-9.