Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes

Life Sciences

Volumn 76, Issue 10, 2005, Pages 1111-1121

  Chen, Biyi ^a,b   Cai, Jingxia ^a   Song, Long Sheng ^c   Wang, Xiaoqing ^d   Chen, Zhihe ^d  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^d KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Calcium channel current; Ginkgo biloba extract; Potassium channel current; Sodium channel current; Ventricular myocytes

Indexed keywords

BILOBALIDE; CALCIUM CHANNEL L TYPE; CATION CHANNEL; GINKGO BILOBA EXTRACT; GINKGOLIDE A; GINKGOLIDE B; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONCENTRATION RESPONSE; DRUG EFFECT; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART VENTRICLE; ISOLATED HEART; MALE; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; RAT; SODIUM CURRENT;

ANIMALS; CALCIUM CHANNELS, L-TYPE; DIMETHYL SULFOXIDE; GINKGO BILOBA; HEART VENTRICLES; ION CHANNELS; MALE; MYOCYTES, CARDIAC; PLANT EXTRACTS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS;

GINKGO BILOBA;

EID: 11144327197     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.08.014     Document Type: Article

References (19)

1. R. Cermak, G. Kuhn, and S. Wolffram The flavonol quercetin activates basolateral K+channels in rat distal colon epithelium British Journal of Pharmacology 135 2002 1183 1190
2. S.S. Chatterjee, E.L. Kondratskaya, and O.A. Krishtal Structure-activity studies with ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators Pharmacopsychiatry 36 Suppl 1 2003 S68 S77
3. B.Y. Chen, C.C. Li, and J.X. Cai The effects of KMBZ-009 on ionic channels Drug Development Research 55 2002 248 249
4. N.M. Cohen, and W.J. Lederer Calcium current in isolated neonatal rat ventricular myocytes Journal of Physiology 391 1987 169 191
5. A.H. Gouliaev, and A. Senning Piracetam and other structurally related nootropics Brain Research Reviews 19 1994 180 222
6. O.P. Hamill, A. Marty, E. Neher, B. Sakmann, and F.J. Sigworth Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches Pflügers Archiv 391 1981 85 100
7. J.S. Kalus, A.A. Piotrowski, C.R. Fortier, X. Liu, J. Kluger, and C.M. White Hemodynamic and eletrocardiographic effects of short-term ginkgo biloba Annals of Pharmacotherapy 37 2003 345 349
8. Y. Kobota, N. Tanaka, and K. Umegaki Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level Life Science 69 2001 2327 2336
9. P.L. Le Bars, M.M. Katz, N. Berman, T.M. Itil, A.M. Freedman, and A.F. Schatzberg A placebo-controlled, double-blind, randomized trial of an extract of ginkgo biloba for dementia Journal of the American Medical Association 278 1997 1327 1332
10. K.M. Maclennan, C.L. Darlington, and P.F. Smith The CNS effects of Ginkgo biloba extracts and ginkgolide B Progress in Neurobiology 67 2002 235 257
11. R. Mitra, and M. Morad A uniform enzymatic method for dissociation of myocytes from heart and stomachs of vertebrates American Journal of Physiology 249 1985 H1056 H1060
12. S. Moosmang, V. Schulla, A. Welling, R. Feil, S. Feil, J.W. Wegener, F. Hofmann, and N. Klugbauer Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation European Molecular Biology Organization Journal 22 22 2003 6027 6034
13. M.T. Nelson, H. Cheng, M. Rubart, L.F. Santana, A.D. Bonev, H.J. Knot, and W.J. Lederer Relaxation of arterial smooth muscle by calcium sparks Science 270 5236 1995, Oct. 27 633 637
14. S. Nishida, and H. Satoh Mechanisms for the vasodilations induced by ginkgo biloba extract and its main constituent, bilobalide, in rat aorta Life Science 72 2003 2659 2667
15. L. Parnetti, U. Senin, and M. Carosi Mental deterioration in old age: results of two multicenter, clinic trials with nimodipine. The nimodipine study group Clinical Therapeutics 15 1993 394
16. H. Satoh Effects of ginkgo biloba extract and bilobalide, a main constituent, on the ionic currents in guinea pig ventrivular cardiomyocytes Arzneimittelforschung 53 2003 407 413
17. H. Satoh, and S. Nishida Electropharmacological actions of ginkgo biloba extract on vascular smooth and heart muscles Clinica Chimica Acta 342 2004 13 22
18. L.S. Song, G.J. Ren, Z.L. Chen, Z.H. Chen, Z.N. Zhou, and H.P. Cheng Electrophysiological effects of protopine in cardiac myocytes: inhibition of multiple cation channel currents British Journal of Pharmacology 129 2000 893 900
19. J.C. Winter The effects of an extract of Ginkgo biloba, EGb 761, on cognitive behavior and longevity in the rat Physiology and Behavior 63 3 1998 425 433