The effect of sepsis upon gentamicin pharmacokinetics in neonates

British Journal of Clinical Pharmacology

Volumn 59, Issue 1, 2005, Pages 54-61

  Lingvall, M ^a   Reith, David ^b,c   Broadbent, R ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c DUNEDIN HOSPITAL   (New Zealand)

Author keywords

Apgar; Gentamicin; Neonate; Pharmacokinetics; Sepsis

Indexed keywords

C REACTIVE PROTEIN; CREATININE; GENTAMICIN;

AGE; APGAR SCORE; BIRTH WEIGHT; BODY WEIGHT; COMPARTMENT MODEL; CONTROLLED STUDY; COVARIANCE; CREATININE BLOOD LEVEL; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFECT; GENDER; GESTATIONAL AGE; GLOMERULUS FILTRATION RATE; HUMAN; INFUSION; MAJOR CLINICAL STUDY; MEDICAL RECORD; NEWBORN; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; SEPSIS;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; FEMALE; GENTAMICINS; HUMANS; INFANT, NEWBORN; INFUSIONS, INTRAVENOUS; MALE; MODELS, BIOLOGICAL; RETROSPECTIVE STUDIES; SEPSIS;

EID: 11144325619     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2005.02260.x     Document Type: Review

References (30)

1. Thomson AH, Kokwaro GO, Muchohi SN, English M, Mohammed S, Edwards G. Population pharmacokinetics of intramuscular gentamicin administered to young infants with suspected severe sepsis in Kenya. Br J Clin Pharmacol 2003; 56 (1): 25-31.
2. Dorman T, Swoboda S, Zarfeshenfard F, Trentler B, Lipsett PA. Impact of altered aminoglycoside Volume of distribution on the adequacy of a three milligram per kilogram loading dose. Crit Care Res Group Surg 1998; 124 (1): 73-8.
3. Power BM, Forbes AM, van Heerden PV, Ilett KF. Pharmacokinetics of drugs used in critically ill adults. Clin Pharmacokinet 1998; 34 (1): 25-56.
4. De Paepe P, Belpaire FM, Buylaert WA. Pharmacokinetic and pharmacodynamic considerations when treating patients with sepsis and septic shock. Clin Pharmacokinet 2002; 41 (14): 1135-51.
5. Oparaoji EC, Siram S, Shoheiber O, Cornwell E, Er Mezghebe HM. Appropriateness of a 4 mg/kg gentamicin or tobramycin loading dose in post-operative septic shock patients. J Clin Pharm Ther 1998; 23 (3): 185-90.
6. Tang GJ, Tang JJ, Lin BS, Kong CW, Lee TY. Factors affecting gentamicin pharmacokinetics in septic patients. Acta Anaesthesiol Scand 1999; 43 (7): 726-30.
7. Triginer C, Izquierdo I, Fernandez R, Rello J, Torrent J, Benito S, et al. Gentamicin Volume of distribution in critically ill septic patients. Intensive Care Med 1990; 16 (5): 303-6.
8. Chelluri L, Warren J, Jastremski MS. Pharmacokinetics of a 3 mg/kg body weight loading dose of gentamicin or tobramycin in critically ill patients. Chest 1989; 95 (6): 1295-7.
9. Oparaoji EC, Cornwell E, Er Hekmat E, Lum Cheong R, Adir JS, Siram S. Aminoglycoside Volume of distribution in postoperative patients with septic shock. Clin Pharm 1993; 12 (2): 131-4.
10. Kreger BE, Craven DE, McCabe WR. Gram-negative bacteremia. IV. Re-evaluation of clinical features and treatment in 612 patients. Am J Med 1980; 68 (3): 344-55.
11. Moore RD, Smith CR, Lietman PS. The association of aminoglycoside plasma levels with mortality in patients with gram-negative bacteremia. J Infect Dis 1984; 149 (3): 443-8.
12. Yaffe SJ, Aranda JV. Pediatric Pharmacology. In: Assael B, Rusconi F, eds. Aminoglycoside Antibiotics, 2 edn Philadelphia, Philadelphia Saunders, 1992, pp. 244-51.
13. Watterberg KL, Kelly HW, Angelus P, Backstrom C. The need for a loading dose of gentamicin in neonates. Ther Drug Monit 1989; 11 (1): 16-20.
14. Ohler KH, Menke JA, Fuller L. Use of higher dose extended interval aminoglycosides in a neonatal intensive care unit. Am J Perinatol 2000; 17 (6): 285-90.
15. Avent ML, Kinney JS, Istre GR, Whitfield JM. Gentamicin and tobramycin in neonates: comparison of a new extended dosing interval regimen with a traditional multiple daily dosing regimen. Am J Perinatol 2002; 19 (8): 413-20.
16. Sheiner LB. Analysis of pharmacokinetic data using parametric models. III. Hypothesis tests and confidence intervals. J Pharmacokinet Biopharm 1986; 14 (5): 539-55.
17. Noone P, Parsons TM, Pattison JR, Slack RC, Garfield-Davies D, Hughes K. Experience in monitoring gentamicin therapy during treatment of serious gram-negative sepsis. BMJ 1974; 1 (906): 477-81.
18. Moore RD, Smith CR, Lietman PS. Association of aminoglycoside plasma levels with therapeutic outcome in gram-negative pneumonia. Am J Med 1984; 77 (4): 657-62.
19. DiCenzo R, Forrest A, Slish JC, Cole C, Guiliet R. A gentamicin pharmacokinetic population model and once-daily dosing algorithm for neonates. Pharmacotherapy 2003; 23 (5): 585-91.
20. Stickland MD, Kirkpatrick CM, Begg EJ, Duffull SB, Oddie SJ, Darlow BA. An extended interval dosing method for gentamicin in neonates. J Antimicrob Chemother 2001; 48 (6): 887-93.
21. Lundergan FS, Glasscock GF, Kim EH, Cohen RS. Once-daily gentamicin dosing in newborn infants. Pediatrics 1999; 103 (6): 1228-34.
22. Thureen PJ, Reiter PD, Gresores A, Stolpman NM, Kawato K, Hall DM. Once- versus twice-daily gentamicin dosing in neonates >/=34 Weeks' gestation: cost-effectiveness analyses. Pediatrics 1999; 103 (3): 594-8.
23. Hayani KC, Hatzopoulos FK, Frank AL, Thummala MR, Hantsch MJ, Schatz B, et al. Pharmacokinetics of once-daily dosing of gentamicin in neonates. J Pediatr 1997; 131 (1): 76-80.
24. Agarwal G, Rastogi A, Pyati S, Wilks A, Pildes RS. Comparison of once-daily versus twice-daily gentamicin dosing regimens in infants > or = 2500 g. J Perinatal 2002; 22 (4): 268-74.
25. Gal P, Ransom JL, Weaver RL. Gentamicin in neonates: the need for loading doses. Am J Perinatol 1990; 7 (3): 254-7.
26. Stolk LM, Degraeuwe PL, Nieman FH, de Wolf MC, de Boer A. Population pharmacokinetics and relationship between demographic and clinical variables and pharmacokinetics of gentamicin in neonates. Ther Drug Monit 2002; 24 (4): 527-31.
27. Rocha MJ, Almeida AM, Afonso E, Martins V, Santos J, Leitao F, et al. The kinetic profile of gentamicin in premature neonates. J Pharm Pharmacol 2000; 52 (9): 1091-7.
28. Adelman RD, Solhaug MJ. Pathophysiology of Body Fluids and Fluid Therapy. In: Behrman, RE, Kliegman, RM, Jenson, HB eds. Nelson Textbook of Pediatrics, 16th edn, Philadelphia: W.B. Saunders 2000.
29. Brion LP, Fleischman AR, Schwartz GJ. Gentamicin interval in newborn infants as determined by renal function and postconceptional age. Pediatr Nephrol 1991; 5 (6): 675-9.
30. Wahl EF, Lahdes-Vasama TT, Churchill BM. Estimation of glomerular filtration rate and bladder capacity, the effect of maturation, ageing, gender and size. BJU Int 2003; 91 (3): 255-62.