G-protein β subunit of Cochliobolus heterostrophus involved in virulence, asexual and sexual reproductive ability, and morphogenesis

Eukaryotic Cell

Volumn 3, Issue 6, 2004, Pages 1653-1663

  Ganem, Sherif ^a,d   Lu, Shun Wen ^b   Lee, Bee Na ^c,e   Chou, David Yu Te ^c,f   Hadar, Ruthi ^a   Turgeon, B Gillian ^b   Horwitz, Benjamin A ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b Department of Obstetrics Gynecology   (United States)

^c SYNGENTA BIOTECHNOLOGY INC   (United States)

^d Weizmann Science Park   (Israel)

^e NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^f SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; FUNGAL PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; PROTEIN KINASE;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; ASCOMYCETES; ASEXUAL REPRODUCTION; BIOLOGICAL MODEL; CELL NUCLEUS; CHEMISTRY; DIMERIZATION; DNA MICROARRAY; FLUORESCENCE MICROSCOPY; FUNGAL GENE; GENE VECTOR; METABOLISM; MOLECULAR GENETICS; MUTATION; NICK END LABELING; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHENOTYPE; PHYLOGENY; PHYSIOLOGY; REPRODUCTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TIME; VIRULENCE;

AMINO ACID SEQUENCE; APOPTOSIS; ASCOMYCOTA; CELL NUCLEUS; DIMERIZATION; FUNGAL PROTEINS; GENES, FUNGAL; GENETIC VECTORS; GTP-BINDING PROTEIN BETA SUBUNITS; IN SITU NICK-END LABELING; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PHYLOGENY; PROTEIN KINASES; REPRODUCTION; REPRODUCTION, ASEXUAL; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TIME FACTORS; VIRULENCE;

COCHLIOBOLUS; COCHLIOBOLUS HETEROSTROPHUS; FUNGI; ZEA MAYS;

EID: 11144314778     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.3.6.1653-1663.2004     Document Type: Article

References (44)

1. Adams, T. H., J. K. Wieser, and J. H. Yu. 1998. Asexual sporulation in Aspergillus nidulans. Microbiol. Mol. Biol. Rev. 62:35-54.
2. Baasiri, R. A., X. Lu, P. S. Rowley, G. E. Turner, and K. A. Borkovich. 1997. Overlapping functions for two G protein alpha subunits in Neurospora crassa. Genetics 147:137-145.
3. Banuett, F. 1998. Signaling in the yeasts: an informational cascade with links to the filamentous fungi. Microbiol. Mol. Biol. Rev. 62:249-274.
4. Boelker, M. 1998. Sex and crime: heterotrimeric G proteins in fungal mating and pathogenesis. Fungal Genet. Biol. 25:143-156.
5. Caviston, J. P., S. E. Tcheperegine, and E. Bi. 2002. Singularity in budding: a role for the evolutionarily conserved small GTPase Cdc42p. Proc. Natl. Acad. Sci. USA 99:12185-12190.
6. Choi, W., and R. Dean. 1997. The adenylate cyclase gene MAC1 of Magnaporthe grisea controls appressorium formation and other aspects of growth and development. Plant Cell 9:1973-1983.
7. Coca, M. A., B. Damsz, D. J. Yun, P. M. Hasegawa, R. A. Bressan, and M. L. Narasimhan. 2000. Heterotrimeric G-proteins of a filamentous fungus regulate cell wall composition and susceptibility to a plant PR-5 protein. Plant J. 22:61-69.
8. Edwards, K., C. Johnstone, and C. Thompson. 1991. A simple and rapid method for the preparation of plant genomic DNA for PCR analysis. Nucleic Acids Res. 19:1349.
9. Felsenstein, J. 1993. PHYLIP (phylogenetic inference package), version 3.57c. Department of Genetics, University of Washington, Seattle.
10. Galagan, J. E., S. E. Calvo, K. A. Borkovich, E. U. Selker, N. D. Read, D. Jaffe, W. FitzHugh, L. J. Ma, S. Smirnov, S. Purcell, B. Rehman, T. Elkins, R. Engels, S. Wang, C. B. Nielsen, J. Butler, M. Endrizzi, D. Qui, P. Ianakiev, D. Bell-Pedersen, M. A. Nelson, M. Werner-Washburne, C. P. Selitrennikoff, J. A. Kinsey, E. L. Braun, A. Zelter, U. Schulte, G. O. Kothe, G. Jedd, W. Mewes, C. Staben, E. Marcotte, D. Greenberg, A. Roy, K. Foley, J. Naylor, N. Stange-Thomann, R. Barrett, S. Gnerre, M. Kamal, M. Kamvysselis, E. Mauceli, C. Bielke, S. Rudd, D. Frishman, S. Krystofova, C. Rasmussen, R. L. Metzenberg, D. D. Perkins, S. Kroken, C. Cogoni, G. Macino, D. Catcheside, W. Li, R. J. Pratt, S. A. Osmani, C. P. DeSouza, L. Glass, M. J. Orbach, J. A. Berglund, R. Voelker, O. Yarden, M. Plamann, S. Seiler, J. Dunlap, A. Radford, R. Aramayo, D. O. Narvig, L. A. Alex, G. Mannhaupt, D. J. Ebbole, M. Freitag, I. Paulsen, M. S. Sachs, E. S. Lander, C. Nusbaum, and B. Birren. 2003. The genome sequence of the filamentous fungus Neurospora crassa. Nature 422:859-868.
11. Giambarella, U., T. Yamatsuji, T. Okamoto, T. Matsui, T. Ikezu, Y. Murayama, M. A. Levine, A. Katz, N. Gautam, and I. Nishimoto. 1997. G protein βγcomplex-mediated apoptosis by familial Alzheimer's disease mutant of APP. EMBO J. 16:4897-4907.
12. Gronover, C. S., D. Kasulke, P. Tudzynski, and B. Tudzynski. 2001. The role of G protein alpha subunits in the infection process of the gray mold fungus Botrytis cinerea. Mol. Plant-Microbe Interact. 14:1293-1302.
13. Horwitz, B. A., A. Sharon., S.-W. Lu, V. Ritter, T. Sandrock, B. G. Turgeon, and O. C. Yoder. 1999. A G protein alpha subunit gene of Cochliobolus heterostrophus involved in mating and appressorium formation. Fungal Genet. Biol. 26:19-32.
14. Jain, S., K. Akiyama, T. Kan, T. Ohguchi, and R. Takata. 2003. The G protein beta subunit FGB1 regulates development and pathogenicity in Fusarium oxysporum. Curr. Genet. 43:79-86.
15. Kasahara, S., and D. L. Nuss. 1997. Targeted disruption of a fungal G-protein beta subunit gene results in increased vegetative growth but reduced virulence. Mol. Plant-Microbe Interact. 10:984-993.
16. Kays, A. M., P. S. Rowley, R. A. Baasiri, and K. A. Borkovich. 2000. Regulation of conidiation and adenylyl cyclase levels by the Gα protein GNA-3 in Neurospora crassa. Mol. Cell. Biol. 20:7693-7705.
17. Kubler, E., H.-U. Mösch, S. Rupp, and M. P. Lisanti. 1997. Gpa2p, a G-protein alpha-subunit, regulates growth in pseudohyphal development in Saccharomyces cerevisiae via a cAMP-dependent mechanism. J. Biol. Chem. 272:20321-20323.
18. Leach, J., B. Lang, and O. Yoder. 1982. Methods for selection of mutants and in vitro culture of Cochliobolus heterostrophus. J. Gen. Microbiol. 128:1719-1729.
19. Lev, S., A. Sharon, R. Hadar, H. Ma, and B. A. Horwitz. 1999. A mitogen-activated protein kinase of the corn leaf pathogen Cochliobolus heterostrophus is involved in conidiation, appressorium formation, and pathogenicity: diverse roles for mitogen-activated protein kinase homlogs in foliar pathogens. Proc. Natl. Acad. Sci. USA 96:13542-13547.
20. Liu, S., and R. Dean. 1997. G protein alpha subunit genes control growth, development, and pathogenicity of Magnaporthe grisea. Mol. Plant-Microbe Interact. 10:1075-1086.
21. Lu, B. C., N. Gallo, and U. Kues. 2003. White-cap mutants and meiotic apoptosis in the basidiomycete Coprinus cinereus. Fungal Genet. Biol. 39: 82-93.
22. Lu, S., L. Lyngholm, G. Yang, C. Bronson, and O. Yoder. 1994. Tagged mutations at the Tox1 locus of Cochliobolous heterostrophus by restriction enzyme-mediated integration. Proc. Natl. Acad. Sci. USA 91:12649-12653.
23. Madhani, H. D., C. A. Styles, and G. R. Fink. 1997. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell 91:673-684.
24. Marek, S., J. Wu, N. Glass, D. Gilchrist, and R. Bostock. 2003. Nuclear DNA degradation during heterokaryon incompatibility in Neurospora crassa. Fungal Genet. Biol. 40:126-137.
25. Momany, M. 2002. Polarity in filamentous fungi: establishment, maintenance and new axes. Curr. Opin. Microbiol. 5:580-585.
26. Mösch, H.-U., R. L. Roberts, and G. R. Fink. 1996. Ras2 signals via the Cdc42/Ste20/mitogen-activated protein kinase module to induce filamentous growth in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 93:5352-5356.
27. Narasimhan, M. L., B. Damsz, M. A. Coca, J. I. Ibeas, D. J. Yun, J. M. Pardo, P. M. Hasegawa, and R. A. Bressan. 2001. A plant defense response effector induces microbial apoptosis. Mol. Cell 8:921-930.
28. Nishimura, M., G. Park, and J. R. Xu. 2003. The G-beta subunit MGB1 is involved in regulating multiple steps of infection-related morphogenesis in Magnaporthe grisea. Mol. Microbiol. 50:231-243.
29. Rosen, S., J. H. Yu, and T. H. Adams. 1999. The Aspergillus nidulans sfaD gene encodes a G protein beta subunit that is required for normal growth and repression of sporulation. EMBO J. 18:5592-5600.
30. Rupp, S., E. Summers, H. J. Lo, H. Madhani, and G. R. Fink. 1999. MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J. 18:1257-1269.
31. Sabbagh, W., Jr., L. J. Flatauer, A. J. Bardwell, and L. Bardwell. 2001. Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation. Mol. Cell 8:683-691.
32. Smith, T. F., C. Gaitatzes, K. Saxena, and E. J. Neer. 1999. The WD repeat: a common architecture for diverse functions. Trends Biochem. Sci. 24:181-185.
33. Turgeon, B. G., H. Bohlmann, L. M. Ciuffetti, S. K. Christiansen, G. Yang, W. Schäfer, and O. C. Yoder. 1993. Cloning and analysis of the mating type genes from Cochliobolus heterostrophus. Mol. Gen. Genet. 238:270-284.
34. Turgeon, B. G., R. C. Garber, and O. C. Yoder. 1987. Development of a fungal transformation system based on selection of sequences with promoter activity. Mol. Cell. Biol. 7:3297-3305.
35. Turner, G. E., and K. A. Borkovich. 1993. Identification of a G protein alpha subunit from Neurospora crassa that is a member of the Gi family. J. Biol. Chem. 268:14805-14811.
36. Tzeng, T. H., L. K. Lyngholm, C. F. Ford, and C. R. Bronson. 1992. A restriction fragment length polymorphism map and electrophoretic karyotype of the fungal maize pathogen Cochliobolus heterostrophus. Genetics 130:81-96.
37. Wang, P., J. R. Perfect, and J. Heitman. 2000. The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans. Mol. Cell. Biol. 20:352-362.
38. Willard, F. S., and M. F. Crouch. 2000. Nuclear and cytoskeletal translocation and localization of heterotrimeric G-proteins. Immunol. Cell Biol. 78: 387-394.
39. Wirsel, S., B. G. Turgeon, and O. C. Yoder. 1996. Deletion of the Cochliobolus heterostrophus mating-type (MAT) locus promotes the function of MAT transgenes. Curr. Genet. 29:241-249.
40. Wu, H. C., P. H. Huang, C. Y. Chiu, and C. T. Lin. 2001. G protein β2 subunit antisense oligonucleotides inhibit cell proliferation and disorganize microtubule and mitotic spindle organization. J. Cell. Biochem. 83:136-146.
41. Xu, J. R. 2000. MAP kinases in fungal pathogens. Fungal Genet. Biol. 31:137-152.
42. Yang, Q., S. Poole, and K. A. Borkovich. 2002. A G-protein beta subunit required for sexual and vegetative development and maintenance of normal G alpha protein levels in Neurospora crassa. Eukaryot. Cell 1:378-390.
43. Zhu, W. Z., M. Zheng, W. J. Koch, R. J. Lefkowitz, B. K. Kobilka, and R. P. Xiao. 2001. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proc. Natl. Acad. Sci. USA 98:1607-1612.
44. Zuber, S., M. J. Hynes, and A. Andrianopoulos. 2002. G-protein signaling mediates asexual development at 25°C but has no effect on yeast-like growth at 37°C in the dimorphic fungus Penicillium mameffei. Eukaryot. Cell 1:440-447.