Treatment of nonalcoholic steatohepatitis: Antioxidants or insulin sensitizers?

Clinical Gastroenterology and Hepatology

Volumn 2, Issue 12, 2004, Pages 1059-1060

  Adams, Leon A ^a   Angulo, Paul ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIDIABETIC AGENT; ANTIOXIDANT; INSULIN SENSITIZING AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PIOGLITAZONE; ROSIGLITAZONE; TROGLITAZONE;

CLINICAL TRIAL; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MODEL; DRUG CONTRAINDICATION; DRUG EFFECT; DRUG EFFICACY; DRUG FATALITY; EDITORIAL; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; LIVER CELL CARCINOMA; LIVER FAILURE; LIVER FIBROSIS; LIVER TOXICITY; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; OBESITY; OXIDATIVE STRESS; SIDE EFFECT; TREATMENT OUTCOME; WEIGHT GAIN;

3-HYDROXYBUTYRIC ACID; ALANINE TRANSAMINASE; ANTIOXIDANTS; DRUG THERAPY, COMBINATION; FATTY ACIDS, NONESTERIFIED; FATTY LIVER; GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; THIAZOLIDINEDIONES; VITAMIN E;

EID: 11144313120     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1542-3565(04)00462-8     Document Type: Editorial

References (20)

1. E.E. Powell, W.G. Cooksley, R. Hanson, J. Searle, J.W. Halliday, L.W. Powell The natural history of nonalcoholic steatohepatitis a follow-up study of forty-two patients for up to 21 years Hepatology 11 1990 74 80
2. K. Kawaguchi, I. Sakaida, M. Tsuchiya, K. Omori, T. Takami, K. Okita Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet Biochem Biophys Res Commun 315 2004 187 195
3. K. Promrat, G. Lutchman, G.I. Uwaifo, R.J. Freedman, A. Soza, T. Heller, E. Doo, M. Ghany, A. Premkumar, Y. Park, T.J. Liang, J.A. Yanovski, D.E. Kleiner, J.H. Hoofnagle A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis Hepatology 39 2004 188 196
4. B.A. Neuschwander-Tetri, E.M. Brunt, K.R. Wehmeier, D. Oliver, B.R. Bacon Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone Hepatology 38 2003 1008 1017
5. C.P. Day, O.F. James Steatohepatitis a tale of two "hits"? Gastroenterology 114 1998 842 845
6. A.J. Sanyal, C. Campbell-Sargent, F. Mirshahi, W.B. Rizzo, M.J. Contos, R.K. Sterling, V.A. Luketic, M.L. Shiffman, J.N. Clore Nonalcoholic steatohepatitis association of insulin resistance and mitochondrial abnormalities Gastroenterology 120 2001 1183 1192
7. M. Parola, G. Leonarduzzi, F. Biasi, E. Albano, M.E. Biocca, G. Poli, M.U. Dianzani Vitamin E dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis Hepatology 16 1992 1014 1021
8. T. Hasegawa, M. Yoneda, K. Nakamura, I. Makino, A. Terano Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis a pilot study Aliment Pharmacol Ther 15 2001 1667 1672
9. J.E. Lavine Vitamin E treatment of nonalcoholic steatohepatitis in children a pilot study J Pediatr 136 2000 734 738
10. L.A. Adams, P. Angulo Vitamins E and C for the treatment of NASH duplication of results but lack of demonstration of efficacy Am J Gastroenterol 98 2003 2348 2350
11. S.A. Harrison, S. Torgerson, P. Hayashi, J. Ward, S. Schenker Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis Am J Gastroenterol 98 2003 2485 2490
12. P. Vajro, C. Mandato, A. Franzese, E. Ciccimarra, S. Lucariello, M. Savoia, G. Capuano, F. Migliaro Vitamin E treatment in pediatric obesity-related liver disease a randomized study J Pediatr Gastroenterol Nutr 38 2004 48 55
13. A.J. Sanyal, M.J. Contos, P.S. Mofrad, C. Sargeant, V.A. Luketic, R.K. Sterling, R.R. Stravitz, M.L. Schiffman, A.S. Mills A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis Clin Gastroenterol Hepatol 2 2004 1107 1115
14. Adams LA, Sanderson S, Lindor KD, Angulo P. The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol (in press).
15. P. Mendez, A. Regev, E. Molina, M. Berho, P. Bejarano, M. Ladino, E. Schiff Sampling error and reliability of liver biopsy in patients with nonalcoholic fatty liver disease (NAFLD) (abstract) Hepatology 38 Suppl 1 2003 673A
16. K.V.N. Menon, P. Angulo, K.D. Lindor Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus Am J Gastroenterol 96 2001 1631 1634
17. T.R. Marcy, M.L. Britton, S.M. Blevins Second-generation thiazolidinediones and hepatotoxicity Ann Pharmacother 38 2004 1419 1423
18. P. Angulo, J.C. Keach, K.P. Batts, K.D. Lindor Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis Hepatology 30 1999 1356 1362
19. I.R. Wanless, J.S. Lentz Fatty liver hepatitis (steatohepatitis) and obesity an autopsy study with analysis of risk factors Hepatology 12 1990 1106 1110
20. Z.M. Younossi, T. Gramlich, C.A. Matteoni, N. Boparai, A.J. McCullough Nonalcoholic fatty liver disease in patients with type 2 diabetes Clin Gastroenterol Hepatol 2 2004 262 265