Cryptic ins(2;11) with clonal evolution showing amplification of 11q23-q25 either on hsr(11) or on dmin, in a patient with AML-M2 [4]

Leukemia

Volumn 18, Issue 12, 2004, Pages 2041-2044

  Vazquez, I ^a,b   Lahortiga, I ^b   Agirre, X ^b   Larrayoz, M J ^a   Vizmanos, J L ^a   Ardanaz, M T ^c   Zeleznik Le, N J ^d   Calasanz, M J ^a   Odero, M D ^a,b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

^c HOSPITAL TXAGORRITXU   (Spain)

^d LOYOLA UNIVERSITY HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT;

ACUTE GRANULOCYTIC LEUKEMIA; AGED; ANAMNESIS; BIOCHEMISTRY; BONE MARROW BIOPSY; CARCINOGENESIS; CASE REPORT; CHROMOSOME 11Q; CHROMOSOME 2Q; CHROMOSOME ANALYSIS; CHROMOSOME REARRANGEMENT; CHROMOSOME REPLICATION; CLINICAL FEATURE; DOUBLE MINUTE CHROMOSOME; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HORMONAL THERAPY; HOSPITAL ADMISSION; HUMAN; HUMAN CELL; KARYOTYPING; LETTER; MALE; MOLECULAR CLONING; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PALLIATIVE THERAPY; PHYSICAL EXAMINATION; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA;

EID: 11144279879     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2403535     Document Type: Letter

References (8)

1. Andersen MK, Christiansen DH, Kirchhoff M, Pedersen-Bjergaard J. Duplication or amplification of chromosome band 11q23, including the unrearranged MLL gene, is a recurrent abnormality in therapy-related MDS and AML, and is closely related to mutation of the TP53 gene and to previous therapy with alkylating agents. Genes Chromosomes Cancer 2001; 31: 33-41.
2. Van Limbergen H, Poppe B, Michaux L, Herens C, Brown J, Noens L et al. Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH. Genes Chromosomes Cancer 2002; 33: 60-72.
3. Michaux L, Wlodarska I, Stul M, Dierlamm J, Mugneret F, Herens C et al. MLL amplification in myeloid leukemias: a study of 14 cases with multiple copies of 11q23. Genes Chromosomes Cancer 2000; 29: 40-47.
4. Cuthbert G, Thompson K, McCullough S, Watmore A, Dickinson H, Telford N et al. MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study. Leukemia 2000; 14: 1885-1891.
5. Zatkova A, Ullmann R, Rouillard JM, Lamb BJ, Kuick R, Hanash SM et al. Distinct sequences on 11q13.5 and 11q23-24 are frequently coamplified with MLL in complexly organized 11q amplicons in AML/MDS patients. Genes Chromosomes Cancer 2004; 39: 263-276.
6. Sait SN, Qadir MU, Conroy JM, Matsui S, Nowak NJ, Baer MR. Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping. Genes Chromosomes Cancer 2002; 34: 42-47.
7. Crossen PE, Morrison MJ, Rodley P, Cochrane J, Morris CM. Identification of amplified genes in a patient with acute myeloid leukemia and double minute chromosomes. Cancer Genet Cytogenet 1999; 113: 126-133.
8. Hogarty MD, Brodeur GM. Gene amplification in human cancers: biological and clinical significance. In Vogelstein B, Kinzler KW (eds). The Genetics Basis of Human Cancer, 2nd edn., New York: McGraw-Hill, 2002, pp 115-128.