Enhancement of topical delivery of drugs via direct penetration by reducing blood flow rate in skin

International Journal of Pharmaceutics

Volumn 288, Issue 2, 2005, Pages 227-233

  Higaki, K ^a   Nakayama, K ^a   Suyama, T ^a   Amnuaikit, Chomchan ^a,b   Ogawara, K ^a   Kimura, T ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b PRINCE OF SONGKLA UNIVERSITY   (Thailand)

Author keywords

Direct penetration; Local therapeutics; Skin blood flow; Topical application; Transdermal absorption

Indexed keywords

DICLOFENAC; PHENAZONE; PHENYLEPHRINE; SALICYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW VELOCITY; BLOOD FLOWMETRY; CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DONOR; DRUG ABSORPTION; DRUG ACTIVITY; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG MUSCLE LEVEL; DRUG PENETRATION; DRUG SCREENING; HEMOCONCENTRATION; IN VIVO STUDY; MALE; MUSCLE; MUSCLE TISSUE; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN; SKIN ABSORPTION; SKIN BLOOD FLOW; SKIN PENETRATION; TIME; VASOCONSTRICTION;

ADMINISTRATION, TOPICAL; ANIMALS; BLOOD FLOW VELOCITY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; MALE; PHARMACEUTICAL PREPARATIONS; RATS; RATS, WISTAR; SKIN; SKIN ABSORPTION;

EID: 11144276492     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.09.025     Document Type: Article

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