Early metabolic acidosis and coma after acetaminophen ingestion

Annals of Emergency Medicine

Volumn 33, Issue 4, 1999, Pages 452-456

  Roth, B ^a   Woo, O ^a   Blanc, P ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ACTIVATED CARBON; BICARBONATE; INSULIN; NALOXONE; PARACETAMOL;

ACUTE TOXICITY; ADOLESCENT; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTERIAL GAS; ARTICLE; CASE REPORT; CENTRAL NERVOUS SYSTEM DEPRESSION; CLINICAL FEATURE; COMA; DRUG BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; INGESTION; LACTATE BLOOD LEVEL; LIVER FAILURE; METABOLIC ACIDOSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SYMPTOM;

EID: 0032941676     PISSN: 01960644     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-0644(99)70312-4     Document Type: Article

References (22)

1. TL Litovitz M Smilkstein L Felberg 1996 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System Am J Emerg Med 15 1997 447 500
2. MJ Smilkstein GL Knapp KW Kulig Efficacy of oral N -acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985) N Engl J Med 319 1988 1557 1562
3. P Blakely BR McDonald Acute renal failure due to acetaminophen ingestion: A case report and review of the literature J Am Soc Nephrol 6 1995 48 53
4. N Ohtani M Matsuzaki Y Anno A case of myocardial damage following acute para-cetamol poisoning Jpn Circ J 53 1989 278 282
5. M Fischereder JP Jaffe Thrombocytopenia following acute acetaminophen overdose Am J Hematol 45 1994 258 259
6. V Caldarola JM Hassett AH Hall Hemorrhagic pancreatitis associated with acetaminophen overdose Am J Gastroenterol 81 1986 579 582
7. SM Douidar I al-Khalil RW Habersang Severe hepatotoxicity, acute renal failure, and pancytopenia in a young child after repeated acetaminophen dosing Clin Pediatr (Phila ) 33 1994 42 45
8. D Luft RM Schmulling M Eggstein Lactic acidosis in biguanide-treated diabetics: A review of 330 cases Diabetologia 14 1978 75 87
9. KC Mills SC Curry Acute iron poisoning Emerg Med Clin North Am 12 1994 397 413
10. CH Linden PL Townsend Metabolic acidosis after acute ibuprofen overdosage J Pediatr 111 1987 922 925
11. HJ Stern Lactic acidosis in paediatrics: Clinical and laboratory evaluation Ann Clin Biochem 31 1994 410 419
12. RM Zabrodski LP Schnurr Anion gap acidosis with hypoglycemia in acetaminophen toxicity Ann Emerg Med 13 1984 956 959
13. TA Gray BM Buckley JA Vale Hyperlactataemia and metabolic acidosis following para-cetamol overdose Q J Med 65 1987 811 821
14. A Zezulka N Wright Severe metabolic acidosis early in paracetamol poisoning Br Med J (Clin Res Ed) 285 1982 851 852
15. J Vale TJ Meridith Metabolic acidosis in paracetamol poisoning BMJ 285 1982 1208
16. MW Lieh-Lai AP Sarnaik JF Newton Metabolism and pharmacokinetics of acetaminophen in a severely poisoned young child J Pediatr 105 1984 125 128
17. RJ Flanagan TG Mant Coma and metabolic acidosis early in severe acute paracetamol poisoning Hum Toxicol 5 1986 179 182
18. VF Price DJ Jollow Increased resistance of diabetic rats to acetaminophen-induced hepatotoxicity J Pharm Exp Ther 220 1982 504 513
19. RR Ramsay MS Rashed SD Nelson In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria Arch Biochem Biophys 273 1989 449 457
20. RL Esterline SD Ray S Ji Reversible and irreversible inhibition of hepatic mitochondrial respiration by acetaminophen and its toxic metabolite, N -acetyl-p-benzoquinoneimine (NAPQI) Biochem Pharmacol 38 1989 2387 2390
21. PC Burcham AW Harman Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes J Biol Chem 266 1991 5049 5054
22. JS Landin SD Cohen EA Khairallah Identification of a 54-kDa mitochondrial acetaminophen-binding protein as aldehyde dehydrogenase Toxicol Appl Pharmacol 141 1996 299 307