Equal frequency of TEL/AML1+ acute lymphoblastic leukemia in children with and without Down syndrome

Pediatric Hematology and Oncology

Volumn 22, Issue 1, 2005, Pages 11-16

  Steiner, Manuel ^a   Attarbaschi, Andishe ^a   König, Margit ^a   Gadner, Helmut ^a   Haas, Oskar A ^a   Mann, Georg ^a  

^a ST ANNA CHILDREN S HOSPITAL   (Austria)

Author keywords

ALL; Down syndrome; Incidence; TEL AML1+

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; CANCER RISK; CHILD; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION 12; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN SYNDROME; FEMALE; FUSION GENE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETIC RISK; HUMAN; IMMUNOPHENOTYPING; MALE; MOLECULAR GENETICS; TEL AML1 GENE; TRISOMY 21;

ADOLESCENT; ADULT; AUSTRIA; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 21; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DOWN SYNDROME; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, ACUTE, L1; MALE; ONCOGENE PROTEINS, FUSION; RETROSPECTIVE STUDIES;

EID: 11144231845     PISSN: 08880018     EISSN: None     Source Type: Journal    
DOI: 10.1080/08880010490515083     Document Type: Article

References (18)

1. + acute lymphoblastic leukemia: an interphase FISH analysis. Leukemia. 2004; in press.
2. Borkhardt A, Cazzaniga G, Viehmann S, et al. Incidence and clinical relevance of TEL/AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials. Associazione Italiana Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Munster Study Group. Blood. 1997;90:571-577.
3. Golub TR, Barker GF, Bohlander SK, et al. Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA. 1995;92:4917-4921.
4. Loh ML, Rubnitz JE. TEL/AML1-positive pediatric leukemia: prognostic significance and therapeutic approaches. Curr Opin Hematol. 2002;9:345-352.
5. Seeger K, Adams HP, Buchwald D, et al. TEL-AML1 fusion transcript in relapsed childhood acute lymphoblastic leukemia. The Berlin-Frankfurt-Munster Study Group. Blood. 1998;91:1716-1722.
6. Hasle H, Clemmensen IH, Mikkelsen M. Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet. 2000;355:165-169.
7. Loncarevic IF, Roitzheim B, Ritterbach J, et al. Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion. Genes Chromosomes. Cancer. 1999;24:272-277.
8. Lanza C, Volpe G, Basso G, et al. The common TEL/AML1 rearrangement does not represent a frequent event in acute lymphoblastic leukaemia occuring in children with Down syndrome. Leukemia. 1997;11:820-821.
9. Chessells JM, Harrison G, Richards SM, et al. Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment. Arch Dis Child. 2001;85:321-325.
10. Schrappe M, Reiter A, Ludwig WD, et al. Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group. Blood. 2000;95:3310-3322.
11. Attarbaschi A, Mann G, Dworzak M, et al. Treatment results of childhood acute lymphoblastic leukemia in Austria: a report of 20 years' experience. Wien Klin Wochenschr. 2002;114:148-157.
12. van der Does-van den Berg A, Bartram CR, Basso G, et al. Minimal requirements for the diagnosis, classification, and evaluation of the treatment of childhood acute lymphoblastic leukemia (ALL) in the "BFM Family" Cooperative Group. Med Pediatr Oncol. 1992;20:497-505.
13. Drabkin HA, Erickson P. Down syndrome and leukemia, an update. Prog Clin Biol Res. 1995;393:169-176.
14. Lange B. The management of neoplastic disorders of haematopoiesis in children with Down's syndrome. Br J Haematol. 2000;110:512-524.
15. Nucifora G, Rowley JD. AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood. 1995;86:1-14.
16. Rainis L, Bercovich D, Strehl S, et al. Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21. Blood. 2003;102:981-986.
17. Gurbuxani S, Vyas P, Crispino JD. Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome. Blood. 2004;103:399-406.
18. Ahmed M, Sternberg A, Hall G, et al. Natural history of GATA1 mutations in Down syndrome. Blood. 2004;103:2480-2489.