Analysis of translational initiation in coxsackievirus B3 suggests an alternative explanation for the high frequency of R+4 in the eukaryotic consensus motif

Journal of Virology

Volumn 79, Issue 2, 2005, Pages 987-996

  Harkins, Stephanie ^a   Cornell, Christopher T ^a   Whitton, J Lindsay ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; AMINO ACID; CAPPED RNA; CYTOSINE; GLYCINE; GUANINE; MESSENGER RNA; POLYPROTEIN; PURINE; VIRUS RNA;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONSENSUS SEQUENCE; COXSACKIE VIRUS B3; DNA FLANKING REGION; EUKARYOTE; GENE MUTATION; HUMAN; HUMAN CELL; IN VIVO STUDY; INTERNAL RIBOSOME ENTRY SITE; KOZAK CONSENSUS SEQUENCE; MALE; MOUSE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; OPEN READING FRAME; PICORNAVIRUS; PRIORITY JOURNAL; RNA FLANKING REGION; RNA SEQUENCE; RNA STRUCTURE; START CODON; TISSUE CULTURE; TRANSLATION INITIATION; TRANSLATION INITIATION SITE; VIRUS GENOME; VIRUS INFECTIVITY; VIRUS REPLICATION;

ANIMALS; CODON; CONSENSUS SEQUENCE; ENTEROVIRUS B, HUMAN; GENOME, VIRAL; HELA CELLS; HUMANS; MICE; MICE, INBRED BALB C; MYOCARDITIS; PANCREATITIS; PROTEIN BIOSYNTHESIS; VIRUS REPLICATION;

EID: 11144225200     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.2.987-996.2005     Document Type: Article

References (42)

1. Arfin, S. M., R. L. Kendall, L. Hall, L. H. Weaver, A. E. Stewart, B. W. Matthews, and R. A. Bradshaw. 1995. Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes. Proc. Natl. Acad. Sci. USA 92:7714-7718.
2. Boissel, J. P., T. J. Kasper, and H. F. Bunn. 1988. Cotranslational amino-terminal processing of cytosolic proteins: cell-free expression of site-directed mutants of human hemoglobin. J. Biol. Chem. 263:8443-8449.
3. α- acetyltransferase families. Trends Biochem. Sci. 23:263-267.
4. α-acetylated. J. Biol. Chem. 251:1009-1014.
5. Chen, C. Y., and P. Sarnow. 1995. Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs. Science 268:415-417.
6. Chow, M., J. F. Newman, D. Filman, J. M. Hogle, D. J. Rowlands, and F. Brown. 1987. Myristoylation of picornavirus capsid protein VP4 and its structural significance. Nature 327:482-486.
7. Dorner, A. J., L. F. Dorner, G. R. Larsen, E. Wimmer, and C. W. Anderson. 1982. Identification of the initiation site of poliovirus polyprotein synthesis. J. Virol. 42:1017-1028.
8. Farazi, T. A., G. Waksman, and J. I. Gordon. 2001. The biology and enzymology of protein N-myristoylation. J. Biol. Chem. 276:39501-39504.
9. Gebhard, J. R., C. M. Perry, S. Harkins, T. Lane, I. Mena, V. C. Asensio, I. L. Campbell, and J. L. Whitton. 1998. Coxsackievirus B3-induced myocarditis: perforin exacerbates disease but plays no detectable role in virus clearance. Am. J. Pathol. 153:417-428.
10. Halim, S. S., S. E. Ostrowski, W. T. Lee, and A. I. Ramsingh. 2000. Immunogenicity of a foreign peptide expressed within a capsid protein of an attenuated coxsackievirus. Vaccine 19:958-965.
11. + T lymphocytes in coxsackievirus B3-induced myocarditis. J. Virol. 69:6720-6728.
12. Henke, A., R. Zell, G. Ehrlich, and A. Stelzner. 2001. Expression of immunoregulatory cytokines by recombinant coxsackievirus B3 variants confers protection against virus-caused myocarditis. J. Virol. 75:8187-8194.
13. Hofling, K., S. Tracy, N. Chapman, K. S. Kim, and L. J. Smith. 2000. Expression of an antigenic adenovirus epitope in a group B coxsackievirus. J. Virol. 74:4570-4578.
14. Huang, S., R. C. Elliott, P. S. Liu, R. K. Koduri, J. L. Weickmann, J. H. Lee, L. C. Blair, P. Ghosh-Dastidar, R. A. Bradshaw, K. M. Bryan, B. Einarson, R. L. Kendall, K. Kolacz, and K. Saito. 1987. Specificity of cotranslational amino-terminal processing of proteins in yeast. Biochemistry 26:8242-8246.
15. Huber, S. A., and L. P. Job. 1983. Cellular immune mechanisms in coxsackievirus group B, type 3 induced myocarditis in BALB/c mice. Adv. Exp. Med. Biol. 161:491-508.
16. Jang, S. K., H. G. Krausslich, M. J. Nicklin, G. M. Duke, A. C. Palmenberg, and E. Wimmer. 1988. A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J. Virol. 62:2636-2643.
17. Kim, K. S., G. Hufnagel, N. M. Chapman, and S. Tracy. 2001. The group B coxsackieviruses and myocarditis. Rev. Med. Virol. 11:355-368.
18. Knowlton, K. U., E. S. Jeon, N. Berkley, R. Wessely, and S. A. Huber. 1996. A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3. J. Virol. 70:7811-7818.
19. Kozak, M. 1986. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44:283-292.
20. Kozak, M. 1987. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J. Mol. Biol. 196:947-950.
21. Kozak, M. 1981. Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. Nucleic Acids Res. 9:5233-5262.
22. Kozak, M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:8125-8148.
23. Kozak, M. 1997. Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6. EMBO J. 16:2482-2492.
24. Kozak, M. 2002. Pushing the limits of the scanning mechanism for initiation of translation. Gene 299:1-34.
25. Krausslich, H. G., C. Holscher, Q. Reuer, J. Harber, and E. Wimmer. 1990. Myristoylation of the poliovirus polyprotein is required for proteolytic processing of the capsid and for viral infectivity. J. Virol. 64:2433-2436.
26. Marc, D., G. Drugeon, A. L. Haenni, M. Girard, and S.van der Werf. 1989. Role of myristoylation of poliovirus capsid protein VP4 as determined by site-directed mutagenesis of its N-terminal sequence. EMBO J. 8:2661-2668.
27. Marc, D., G. Masson, M. Girard, and S. van der Werf. 1990. Lack of myristoylation of poliovirus capsid polypeptide VP0 prevents the formation of virions or results in the assembly of noninfectious virus particles. J. Virol. 64:4099-4107.
28. Maurer-Stroh, S., M. Gouda, M. Novatchkova, A, Schleiffer, G. Schneider, F. L. Sirota, M. Wildpaner, N. Hayashi, and F. Eisenhaber. 13 February 2004. MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins. Genome Biol. 5(3):R21. [Online.] http://genomebiology.eom/2004/5/3/R21.
29. Mena, I., C. Fischer, J. R. Gebhard, C. M. Perry, S. Harkins, and J. L. Whitton. 2000. Coxsackievirus infection of the pancreas: evaluation of receptor expression, pathogenesis, and immunopathology. Virology 271:276-288.
30. Molla, A., A. V. Paul, and E. Wimmer. 1991. Cell-free, de novo synthesis of poliovirus. Science 254:1647-1651.
31. Moscufo, N., J. Simons, and M. Chow. 1991. Myristoylation is important at multiple stages in poliovirus assembly. J. Virol. 65:2372-2380.
32. Ohlmann, T., and R. J. Jackson. 1999. The properties of chimeric picornavirus IRESes show that discrimination between internal translation initiation sites is influenced by the identity of the IRES and not just the context of the AUG codon. RNA. 5:764-778.
33. Paul, A. V., A. Schultz, S. E. Pincus, S. Oroszlan, and E. Wimmer. 1987. Capsid protein VP4 of poliovirus is N-myristoylated. Proc. Natl. Acad. Sci. USA 84:7827-7831.
34. Pelletier, J., G. Kaplan, V. R. Racaniello, and N. Sonenberg. 1988. Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5′ noncoding region. Mol. Cell. Biol. 8:1103-1112.
35. Pelletier, J., and N. Sonenberg. 1988. Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334:320-325.
36. Peri, S., and A. Pandey. 2001. A reassessment of the translation initiation codon in vertebrates. Trends Genet. 17:685-687.
37. Ramsingh, A. I. 1997. Coxsackieviruses and pancreatitis. Front. Biosci. 2:e53-e62.
38. Sakai, H., T. Washio, R. Saito, A. Shinagawa, M. Itoh, K. Shibata, P. Carninci, H. Konno, J. Kawai, Y. Hayashizaki, and M. Tomita. 2001. Correlation between sequence conservation of the 5′ untranslated region and codon usage bias in Mus musculus genes. Gene 276:101-105.
39. Sherman, F., J. W. Stewart, and S. Tsunasawa. 1985. Methionine or not methionine at the beginning of a protein. Bioessays 3:27-31.
40. + T cells in controlling picornaviral infection. J. Virol. 75:2377-2387.
41. Tracy, S., K. Hofling, S. Pirruccello, P. H. Lane, S. M. Reyna, and C. J. Gauntt. 2000. Group B coxsackievirus myocarditis and pancreatitis: connection between viral virulence phenotypes in mice. J. Med. Virol. 62:70-81.
42. Woodruff, J. F. 1980. Viral myocarditis: a review. Am. J. Pathol. 101:425-484.