Virus-like particles as carriers for T-cell epitopes: Limited inhibition of T-cell priming by carrier-specific antibodies

Journal of Virology

Volumn 79, Issue 2, 2005, Pages 717-724

  Ruedl, Christiane ^a   Schwarz, Katrin ^a   Jegerlehner, Andrea ^a   Storni, Tazio ^a   Manolova, Vania ^a   Bachmann, Martin F ^a  

^a CYTOS BIOTECHNOLOGY AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

6 CARBOXYFLUORESCEIN; HEPATITIS B CORE ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RECOMBINANT VACCINE; VIRUS VACCINE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; VIRUS CARRIER; VIRUS INFECTION; VIRUS PARTICLE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, VIRAL; EPITOPES, T-LYMPHOCYTE; FEMALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; VACCINATION; VIRION;

EID: 11144221879     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.2.717-724.2005     Document Type: Article

References (37)

1. Albrecht, P., F. A. Ennis, E. J. Saltzman, and S. Krugman. 1977. Persistence of maternal antibody in infants beyond 12 months: mechanism of measles vaccine failure. J. Pediatr. 91:715-718.
2. Bachmann, M. F., C. Bast, H. Hengartner, and R. M. Zinkernagel. 1994. Immunogenicity of a viral model vaccine after different inactivation procedures. Med. Microbiol. Immunol. (Berlin) 183:95-104.
3. Bachmann, M. F., T. M. Kundig, C. P. Kalberer, H. Hengartner, and R. M. Zinkernagel. 1993. Formalin inactivation of vesicular stomatitis virus impairs T-cell- but not T-help-independent B-cell responses. J. Virol. 67:3917-3922.
4. Bachmann, M. F., M. B. Lutz, G. T. Layton, S. J. Harris, T. Fehr, M. Rescigno, and P. Ricciardi-Castagnoli. 1996. Dendritic cells process exogenous viral proteins and virus-like particles for class I presentation to CD8+ cytotoxic T lymphocytes. Eur. J. Immunol. 26:2595-2600.
5. Bangham, C. R. 1986. Passively acquired antibodies to respiratory syncytial virus impair the secondary cytotoxic T-cell response in the neonatal mouse. Immunology 59:37-41.
6. Battegay, M., S. Cooper, A. Althage, J. Banziger, H. Hengartner, and R. M. Zinkernagel. 1991. Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. J. Virol. Methods 33:191-198. (Erratum, 35:115, erratum, 38:263, 1992.)
7. Braciale, T. J., L. A. Morrison, M. T. Sweetser, J. Sambrook, M. J. Gething, and V. L. Braciale. 1987. Antigen presentation pathways to class 1 and class II MHC-restricted T lymphocytes. Immunol. Rev. 98:95-114.
8. Da Silva, D. M., D. V. Pastrana, J. T. Schiller, and W. M. Kast. 2001. Effect of preexisting neutralizing antibodies on the anti-tumor immune response induced by chimeric human papillomavirus virus-like particle vaccines. Virology 290:350-360.
9. Den Haan, J. M., and M. J. Bevan. 2002. Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo. J. Exp. Med. 196:817-827.
10. den Haan, J. M., S. M. Lehar, and M. J. Bevan. 2000. CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo. J. Exp. Med. 192:1685-1696.
11. Engering, A. J., M. Cella, D. M. Fluitsma, E. C. Hoefsmit, A. Lanzavecchia, and J. Pieters. 1997. Mannose receptor mediated antigen uptake and presentation in human dendritic cells. Adv. Exp. Med. Biol. 417:183-187.
12. Etlinger, H. M., D. Gillessen, H. W. Lahm, H. Matile, H. J. Schonfeld, and A. Trzeciak. 1990. Use of prior vaccinations for the development of new vaccines. Science 249:423-425.
13. Germain, R. N. 1986. Immunology. The ins and outs of antigen processing and presentation. Nature 322:687-689.
14. Jondal, M., R. Schirmbeck, and J. Reimann. 1996. MHC class I-restricted CTL responses to exogenous antigens. Immunity 5:295-302.
15. Kalergis, A. M., and J. V. Ravetch. 2002. Inducing tumor immunity through the selective engagement of activating Fcgamma receptors on dendritic cells. J. Exp. Med. 195:1653-1659.
16. Lanzavecchia, A. 1987. Antigen uptake and accumulation in antigen-specific B cells. Immunol. Rev. 99:39-51.
17. Lenz, P., P. M. Day, Y. Y. Pang, S. A. Frye, P. N. Jensen, D. R. Lowy, and J. T. Schiller. 2001. Papillomavirus-like particles induce acute activation of dendritic cells. J. Immunol. 166:5346-5355.
18. Morrison, L. A., A. E. Lukacher, V. L. Braciale, D. P. Fan, and T. J. Braciale. 1986. Differences in antigen presentation to MHC class I- and class II-restricted influenza virus-specific cytolytic T lymphocyte clones. J. Exp. Med. 163:903-921.
19. Oehen, S., and K. Brduscha-Riem. 1998. Differentiation of naive CTL to effector and memory CTL: correlation of effector function with phenotype and cell division. J. Immunol. 161:5338-5346.
20. Oxenius, A., M. F. Bachmann, P. G. Ashton-Rickardt, S. Tonegawa, R. M. Zinkernagel, and H. Hengartner. 1995. Presentation of endogenous viral proteins in association with major histocompatibility complex class II: on the role of intracellular compartmentalization, invariant chain and the TAP transporter system. Eur. J. Immunol. 25:3402-3411.
21. Oxenius, A., M. F. Bachmann, R. M. Zinkernagel, and H. Hengartner. 1998. Virus-specific MHC class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur. J. Immunol. 28:390-400.
22. Perkins, F. T., R. Yetts, and W. Gaisford. 1959. A comparison of the responses of 100 infants to primary poliomyelitis immunization with two and with three doses of vaccine. Br. Med. J. 1:1083-1086.
23. Pircher, H., K. Burki, R. Lang, H. Hengartner, and R. M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342:559-561.
24. Pumpens, P., and E. Grens. 2001. HBV core particles as a carrier for B cell/T cell epitopes. Intervirology 44:98-114.
25. Regnault, A., D. Lankar, V. Lacabanne, A. Rodriguez, C. Thery, M. Rescigno, T. Saito, S. Verbeek, C. Bonnerot, P. Ricciardi-Castagnoli, and S. Amigorena. 1999. Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J. Exp. Med. 189:371-380.
26. Ruedl, C., M. Kopf, and M. F. Bachmann. 1999. CD8(+) T cells mediate CD40-independent maturation of dendritic cells in vivo. J. Exp. Med. 189:1875-1884.
27. Ruedl, C., T. Storni, F. Lechner, T. Bachi, and M. F. Bachmann. 2002. Cross-presentation of virus-like particles by skin-derived CD8(-) dendritic cells: a dispensable role for TAP. Eur. J. Immunol. 32:818-825.
28. Sallusto, F., M. Cella, C. Danieli, and A. Lanzavecchia. 1995. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: down-regulation by cytokines and bacterial products. J. Exp. Med. 182:389-400.
29. Schafer, K., M. Muller, S. Eaath, A. Henn, W. Osen, H. Zentgraf, A. Benner, L. Gissmann, and I. Jochmus. 1999. Immune response to human papillomavirus 16 L1E7 chimeric virus-like particles: induction of cytotoxic T cells and specific tumor protection. Int. J. Cancer 81:881-888.
30. Siegrist, C. A. 2001. Neonatal and early life vaccinology. Vaccine 19:3331-3346.
31. Siegrist, C. A., C. Barrios, X. Martinez, C. Brandt, M. Berney, M. Cordova, J. Kovarik, and P. H. Lambert. 1998. Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice. Eur. J. Immunol. 28:4138-4148.
32. Storni, T., and M. F. Bachmann. 2004. Loading of the MHC class I and MHC class II presentation pathways by exogenous antigens: a quantitative in vivo comparison. J. Immunol. 172:6129-6135.
33. Storni, T., F. Lechner, I. Erdmann, T. Bachi, A. Jegerlehner, T. Dumrese, T. M. Kundig, C. Ruedl, and M. F. Bachmann. 2002. Critical role for activation of antigen-presenting cells in priming of cytotoxic T cell responses after vaccination with virus-like particles. J. Immunol. 168:2880-2886.
34. Storni, T., C. Ruedl, W. A. Renner, and M. F. Bachmann. 2003. Innate immunity together with duration of antigen persistence regulate effector T cell induction. J. Immunol. 171:795-801.
35. Storni, T., C. Ruedl, K. Schwarz, R. A. Schwendener, W. A. Renner, and M. F. Bachmann. 2004. Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects. J. Immunol. 172:1777-1785.
36. Wallace, P. K., K. Y. Tsang, J. Goldstein, P. Correale, T. M. Jarry, J. Schlom, P. M. Guyre, M. S. Ernstoff, and M. W. Fanger. 2001. Exogenous antigen targeted to FcgammaRI on myeloid cells is presented in association with MHC class I. J. Immunol. Methods 248:183-194.
37. Zinkernagel, R. M. 2002. On cross-priming of MHC class I-specific CTL: rule or exception? Eur. J. Immunol. 32:2385-2392.