A model of the dynamic relationship between blood flow and volume changes during brain activation

Journal of Cerebral Blood Flow and Metabolism

Volumn 24, Issue 12, 2004, Pages 1382-1392

  Kong, Yazhuo ^a   Zheng, Ying ^a   Johnston, David ^a   Martindale, John ^a   Jones, Myles ^a   Billings, Steve ^a   Mayhew, John ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Balloon; Cerebral blood flow; Cerebral blood volume; Delayed compliance; Dynamic modeling; Windkessel

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BLOOD RHEOLOGY; BLOOD VESSEL COMPLIANCE; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN DEPTH STIMULATION; CALCULATION; CONTROLLED STUDY; ELECTROSTIMULATION; HEMODYNAMICS; HYPERCAPNIA; MATHEMATICAL MODEL; MICROVASCULATURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN BLOOD LEVEL; PARAMETER; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; SIGNAL DETECTION; STEADY STATE;

EID: 10944272481     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000141500.74439.53     Document Type: Article

References (16)

1. Bassingthwaighte JB, Chaloupka M (1984) Sensitivity functions in the estimation of parameters of cellular exchange. Fed Proc 43:180-184
2. Buxton RB, Wong EC, Frank LR (1998) Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn Reson Med 39:855-864
3. Friston KJ, Mechelli A, Turner R, Price CJ (2000) Nonlinear responses in fMRI: the balloon model, volterra kernels and other hemodynamics. Neuroimage 12:466-477
4. Grubb RL, Raichle ME, Eichling JO, Ter-Pergossian MM (1974) The effects of changes in PACO2 on cerebral blood volume, blood flow and vascular mean transit time. Stroke 5:630-639
5. Jones M, Berwick J, Johnston D, Mayhew J (2001) Concurrent optical imaging spectroscopy and laser-Doppler flowmetry: the relationship between blood flow, oxygenation, and volume in rodent barrel cortex. Neuroimage 13:1002-1015
6. Jones M, Berwick J, Mayhew J (2002) Changes in blood flow, oxygenation, and volume following extended stimulation of rodent barrel cortex. Neuroimage 15:474-487
7. Kleinfeld D, Mitra PP, Helmchen F, Denk W (1998) Fluctions and Stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proc Natl Acad Sci U S A 95:15741-15746
8. Martindale J, Mayhew J, Berwick J, Jones M, Martin C, Johnston D, Redgrave P, Zheng Y (2003) The hemodynamic impulse response to a single neural event. J Cereb Blood Flow Metab 23:546-555
9. Mandeville JB, Marota JJA, Kosofsky BE, Keltner JR, Weissleder R, Rosen BR, Weisskoff RM (1998) Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magn Reson Med 39:615-624
10. Mandeville JB, Marota JJ, Ayata C, Zaharchuk G, Moskowitz MA, Rosen BR, Weisskoff RM (1999) Evidence of a cerebrovascular postarteriole Windkessel with delayed compliance. J Cereb Blood Flow Metab 19:679-689
11. Mayhew J, Hu D, Zheng Y, Askew S, Hou Y, Berwick J, Coffey PJ, Brown N (1998) An evaluation of linear model analysis techniques for processing images of microcirculation activity. Neuroimage 7:49-71
12. Nakagawa H, Lin SZ, Bereczki D, Gesztelyi G, Otsuka T, Wei L, Hans EJ, Acuff VR, Chen JL, Pettigrew KD, Patlak CS, Blasberg RG, Fenstermacher JD (1995) Blood volumes, hematocrits, and transit-times in parenchymal microvascular systems of the rat brain. In: Diffusion and perfusion magnetic resonance imaging (Le Bthan D, Ed). New York, NY: Raven Press.
13. Nilsson GE (1984) Signal processor for laser Doppler tissue flowmeters. Med Biol Eng Comput 22:343-348
14. Roy CS, Sherrington CS (1890) On the regulation of the blood supply of the brain J Physiol (Lond) 11:85-108
15. Schulte ML, Wood JD, Hudetz AG (2003) Cortical electrical stimulation alters erythrocyte perfusion pattern in the cerebral capillary network of the rat. Brain Res 963:81-92
16. Zheng Y, Martindale J, Johnston D, Jones M, Berwick J, Mayhew J (2002) A model of the hemodynamic response and oxygen delivery to brain. Neuroimage 16:617-637