Synthesis of 2-amino-4-chloro-6,9-bis-(2,4-dimethoxybenzyl)-6,7,8,9- tetrahydro-5H-pyrimido[4,5-e][1,4]diazepine: A potentially useful intermediate to pyrimido-[4,5-e][1,4]diazepine-based folates

Heterocyclic Communications

Volumn 10, Issue 6, 2004, Pages 405-406

  Huddleston, Noah E ^a   Harris, Jessica L ^a   Nguyen, Hang L ^a   Ray, Partha S ^a  

^a UNIVERSITY OF WEST GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 CHLORO 6,9 BIS(2,4 DIMETHOXYBENZYL) 6,7,8,9 TETRAHYDRO 5H PYRIMIDO[4,5 E][1,4]DIAZEPINE; 2 AMINO 4,6 DICHLORO 5 CHLOROMETHYLPYRIMIDINE; DIAMINE DERIVATIVE; DIAZEPINE DERIVATIVE; FOLIC ACID DERIVATIVE; N,N' BIS(2,4 DIMETHOXYBENZYL)ETHANE 1,2 DIAMINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; REACTION ANALYSIS; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 10944222893     PISSN: 07930283     EISSN: None     Source Type: Journal    
DOI: 10.1515/HC.2004.10.6.405     Document Type: Article

References (9)

1. D.P. Parker, S.A. Hughes, D.L. Parker and P.S. Ray, Heterocycl. Commun. 8, 419 (2002)
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3. S.W. Baldwin, A. Tse, L.S. Gossett, E.C. Taylor, A. Rosowsky, C. Shih and R.G. Moran, Biochemistry, 30, 1997 (1991), and references cited therein
4. E.C. Taylor and J.E. Dowling, Bioorg. Med. Chem. Lett. 7, 453 (1997)
5. M.W. Read, M.L. Miller and P.S. Ray, Tetrahedron, 55, 373 (1999)
6. L. Bell, H.M. McGuire and G.A. Freeman, J. Heterocycl. Chem. 20, 41 (1983)
7. 6) δ 4.45 (d, J = 4.8 Hz, 2H), 5.07 (t, J = 4.8 Hz, 1H), 7.50 (br s, 2H)
8. 3) δ 4.72 (s, 2H), 5.43 (br s, 2H)
9. +), found m/z 500.20190