Synthesis of N-{[4-(2-amino-4(3H)-oxo-5,6,7,8-tetrahydro-(9H)- pyrimido[4,5-b]-azepin-6-yl)methyl]benzoyl}-L-glutamic acid and two of its conformationally-restricted analogs

Tetrahedron

Volumn 55, Issue 2, 1999, Pages 373-392

  Read, Mark W ^a   Miller, Michael L ^a   Ray, Partha S ^a  

^a University of Memphis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(8 AMINO 10(9H) OXO) 3,4,5,6 TETRAHYDRO (6H) ISOXAZOLINO[3,4 D]PYRIMIDO[4,5 B]AZEPIN 3 YL]BENZOYLGLUTAMIC ACID; ANTINEOPLASTIC AGENT; FOLIC ACID DERIVATIVE; LOMETREXOL; N [(8 AMINO 10(9H) OXO) 4,5 DIHYDRO (6H) ISOXAZOLO[3,4 D]PYRIMIDO[4,5 B]AZEPIN 3 YL]BENZOYLGLUTAMIC ACID; N [[4 (2 AMINO 4(3H) OXO 5,6,7,8 TETRAHYDRO (9H) PYRIMIDO[4,5 B]AZEPIN 6 YL)METHYL]BENZOYL]GLUTAMIC ACID; UNCLASSIFIED DRUG;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLON CARCINOMA; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0033534582     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0040-4020(98)01060-6     Document Type: Article

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