Closing in on multiple cancer targets

Scientist

Volumn 16, Issue 7, 2002, Pages 29-31

  Steinberg, Douglas ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BLOCKING AGENT; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; IMATINIB; LAPATINIB; N [4 (3 CHLORO 4 FLUOROANILINO) 7 (3 MORPHOLINOPROPOXY) 6 QUINAZOLINYL]ACRYLAMIDE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TRASTUZUMAB;

ARTICLE; BRAIN CANCER; BREAST CANCER; CLINICAL TRIAL; DIARRHEA; ENZYME ACTIVITY; FOOD AND DRUG ADMINISTRATION; HEAD AND NECK CANCER; HUMAN; LUNG CANCER; MULTIMODALITY CANCER THERAPY; MULTIPLE CANCER; OVARY CANCER; PANCREAS CANCER; PROSTATE CANCER; RASH; SIDE EFFECT; STOMACH CANCER;

EID: 10844277291     PISSN: 08903670     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. J.H. Schiller et al., "Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer," New England Journal of Medicine, 346:92-8, Jan. 10, 2002.
2. For further information on EGFR biology, see the AstraZeneca-sponsored Web site: www.egf-info.com
3. S.-Y Lin et al., "Nuclear localization of EGF receptor and its potential new role as a transcription factor," Nature Cell Biology, 3-802-8, Sept. 1, 2001.
4. R Pai et al., "Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy," Nature Medicine, 8:289-93, March 2002.
5. P.C Bishop et al., "Differential sensitivity of cancer cells to inhibitors of the epidermal growth factor receptor family," Oncogene, 21:119-27, Jan 3, 2002
6. R Bianco et al., "EGF receptor-overexpressing tumor cells that lack PTEN/MMAC1 and RB are resistant to small molecule EGFR kinase inhibitors," Abstract #4567, 2001 meeting of American Association for Cancer Research.