Surface immunoglobulin-deficient Epstein-Barr virus-infected B cells in the peripheral blood of pediatric solid-organ transplant recipients

Journal of Clinical Microbiology

Volumn 42, Issue 12, 2004, Pages 5802-5810

  Schauer, Elizabeth ^a   Webber, Steven ^a   Green, Michael ^a   Rowe, David ^a,b  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN M; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN;

ARTICLE; B LYMPHOCYTE; BLOOD; CELL LINEAGE; CHILD; DISEASE ASSOCIATION; EPISOME; EPSTEIN BARR VIRUS; FEMALE; GENE NUMBER; GENETIC RISK; HETEROZYGOTE DETECTION; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN DEFICIENCY; INFANT; LYMPHOPROLIFERATIVE DISEASE; MALE; ORGAN TRANSPLANTATION; PHENOTYPE; PRIORITY JOURNAL; RECIPIENT; VIRUS GENOME; VIRUS INFECTION; VIRUS LOAD;

B-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; GENE DOSAGE; HERPESVIRUS 4, HUMAN; HUMANS; INFANT; MALE; ORGAN TRANSPLANTATION; RECEPTORS, ANTIGEN, B-CELL; VIRAL LOAD;

DNA VIRUSES; HERPESVIRIDAE; HUMAN HERPESVIRUS 4;

EID: 10844275372     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.42.12.5802-5810.2004     Document Type: Article

References (38)

1. Babcock, G., L. Decker, M. Volk, and D. Thorley-Lawson. 1998. EBV persistence in memory B cells in vivo. Immunity 9:395-404.
2. Babcock, G., L. Decker, R. Freeman, and D. Thorley-Lawson. 1999. Epstein-Barr virus-infected resting memory B cells, not proliferating lymphoblasts, accumulate in the peripheral blood of immunosuppressed patients. J. Exp. Med. 190:567-576.
3. Brauninger, A., T. Spleker, A. Mottok, A. Baur, R. Kuppers, and M. L. Hansmann. 2003. EBV-positive lymphoproliferations in post-transplant patients show immunoglobulin V gene mutation patterns suggesting interference of EBV with normal B cell differentiation processes. Eur. J. Immunol. 33:1593-1602.
4. Brauninger, A., T. Spieker, K. Willenbrock, P. Gaulard, H. Wacker, K. Rajewsky, M.-L. Hansmann, and R. Kuppers. 2001. Survival and clonal expansion of mutating "forbidden" (immunoglobulin receptor-deficient) Epstein-Barr virus-infected B cells in angioimmunoblastic T cell lymphoma. J. Exp. Med. 194:927-940.
5. Buteau, C., and C. Paya. 2001. Clinical usefulness of Epstein-Barr viral load in solid organ transplantation. Liver Transplant. 7:157-159.
6. Decker, L., L. Klaman, and D. Thorley-Lawson. 1996. Detection of the latent form of Epstein-Barr virus DNA in the peripheral blood of healthy individuals. J. Virol. 70:3286-3289.
7. Finn, I., J. Reyes, J. Bueno, and E. Yunis. 1998. Epstein-Barr virus infections in children after transplantation of the small intestine. Am. J. Surg. Pathol. 22:299-309.
8. Green, M., J. Reyes, S. Webber, M. Michaels, and D. Rowe. 1999. The role of viral load in the diagnosis, management, and possible prevention of Epstein-Barr virus associated posttransplant lymphoproliferative disease following solid organ transplantation. Curr. Opin. Organ Transplant. 4:292-296.
9. Green, M., M. Michaels, S. Webber, D. Rowe, and J. Reyes. 1999. The management of Epstein-Barr virus associated post-transplant lymphoproliferative disorders in pediatric solid organ transplant recipients. Pediatr. Transplant. 3:271-281.
10. Green, M., T. Cacciarelli, G. Mazariegos, L. Sigurdsson, L. Qu, D. Rowe, and J. Reyes. 1998. Serial measurement of Epstein-Barr viral load in peripheral blood in pediatric liver transplant recipients during treatment for posttransplant lymphoproliferative diseases. Transplantation 66:1614-1644.
11. Hicks, M. J., J. Jones, L. Minnich, K. Weigle, A. C. Thies, and J. Layton. 1983. Age-related changes in T- and B-lymphocyte subpopulations in the peripheral blood. Arch. Pathol. Lab. Med. 107:518-523.
12. Joseph, A., G. Babcock, and D. Thorley-Lawson. 2000. EBV persistence involves strict selection of latently infected B cells. J. Immunol. 165:2975-2981.
13. Kaleem, Z., A. Hassan, M. Pathan, and G. White. 2004. Flow cytometric evaluation of posttransplant B-cell lymphoproliferative disorders. Arch. Pathol. Lab. Med. 128:181-189.
14. Kanzler, H., R. Kuppers, M. Hansmann, and K. Rajewsky. 1996. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J. Exp. Med. 184:1495-1505.
15. Kogan, D., M. Burroughs, S. Emre, T. Fishbein, A. Moscona, C. Ramson, and B. Shneider. 1999. Prospective longitudinal analysis of quantitative Epstein-Barr virus polymerase chain reaction in pediatric transplant recipients. Transplantation 67:1068-1070.
16. Kuppers, R., K. Rajewsky, M. Zhao, et al. 1994. Hodgkin disease: Hodgkin and Reed-Sterberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc. Natl. Acad. Sci. USA 91:10962-10966.
17. Limaye, A., H. Meei-Li, E. Atienza, J. Ferrenberg, and L. Corey. 1999. Detection of Epstein-Barr virus DNA in sera from transplant recipients with lymphoproliferative disorders. J. Clin. Microbiol. 37:1113-1116.
18. Lucas, K., R. Burtin, S. Zimmerman, J. Wang, K. Cornetta, K. Robertson, C. Lee, and D. Emanuel. 1998. Semi-quantitative Epstein-Barr virus (EBV) polymerase chain reaction for the determination of patients at risk for EBV-induced lymphoproliferative disease after stem cell transplantation. Blood 91:3654-3661.
19. Mihalov, M. I., P. Gattusa, K. Abraham, E. Holmes, and V. Reddy. 1996. Incidence of post-transplant malignancy among 674 solid-organ transplant recipients at a single center. Clin. Transplant. 10:248-255.
20. Miyashita, E., B. Yang, G. Babcock, and D. Thorley-Lawson. 1997. Identification of the site of Epstein-Barr virus persistence in vivo as a resting B cell. J. Virol. 71:4882-4891.
21. Miyashita, E., B. Yang, K. Lam, D. Crawford, and D. Thorley-Lawson. 1995. A novel form of Epstein-Barr virus latency in normal B cells in vivo. Cell 80:593-601.
22. Nalesnik, M., R. Jaffe, T. Starzl, A. Demetris, K. Porter, J. Burnham, L. Makonka, M. Ho, and J. Locker. 1988. The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression. Am. J. Pathol. 133:173-192.
23. Ohga, S., E. Kubo, A. Nomura, N. Suga, E. Ishii, A. Suminoe, T. Inamitsu, A. Matsuzaki, N. Kasuga, and T. Hara. 2001. Quantitative monitoring of circulating Epstein-Barr virus DNA for predicting the development of posttransplant lymphoproliferative disease. Int. J. Hematol. 73:323-326.
24. Paya, C. V., J. J. Fung, M. A. Nalesnik, E. Kieff, M. Green, G. Gores, T. M. Habermann, R. H. Wiesner, L. J. Swinnen, E. S. Woodle, and J. S. Bromberg. 1999. Epstein-Barr virus-induced posttransplant lymphoproliferative disorders. Transplantation 68:1517-1525.
25. Rickinson, A. B., and E. Kieff. 1996. Epstein-Barr virus, p. 2397. In B. N. Fields, D. M. Kneip, and P. M. Howley (ed.), Virology, vol. 2. Raven Press, New York, N.Y.
26. Riddler, S., M. Breining, and J. McKnight. 1994. Increased levels of circulating Epstein-Barr virus-infected lymphocytes and decreased EBV nuclear antigen antibody responses are associated with the development of posttransplant lymphoproliferative disease in solid organ transplant recipients. Blood 84:1972-1984.
27. Rose, C., M. Green, S. Webber, D. Ellis, J. Reyes, and D. Rowe. 2001. Pediatric solid-organ transplant patients carry chronic loads of Epstein-Barr virus exclusively in the immunoglobulin D-negative B-cell compartment. J. Clin. Microbiol. 39:1407-1415.
28. Rose, C., M. Green, S. Webber, L. Kingsley, R. Day, S. Watkins, J. Reyes, and D. Rowe. 2001. Detection of EBV genomes in peripheral blood B cells from solid-organ transplant recipients by fluorescent in situ hybridization. J. Clin. Microbiol. 40:2533-2544.
29. Rowe, D., L. Qu, J. Reyes, N. Jabbour, E. Yunis, P. Putnam, S. Todo, and M. , Green. 1997. Use of quantitative competitive PCR to measure Epstein-Barr virus genome load in the peripheral load of pediatric transplant patients with lymphoproliferative disease. J. Clin. Microbiol. 35:1612-1615.
30. Rowe, M., G. Niedobittek, and C. Young. 1998. EBV gene expression in posttransplant lymphoproliferative disorders. Springer Semin. Immunopathol. 20:389-403.
31. Servi, J., E. Stevens, E. Verchuuren, I. Pronk, W. van der Bij, M. Harmsen, T. The, C. Meijer, A. van der Brule, and J. Middledorp. 2001. Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for the early detection of posttransplant lymphoproliferative disease in high risk patients. Blood 97:1165-1171.
32. Shapiro, R., M. Nalesnik, J. McCauley, S. Fedorek, M. Jordan, V. Scantlebury, A. Jain, C. Vivas, D. Ellis, S. Lombardozzi-Lane, P. Randhawa, J. Johnston, T. Hakala, R. Simmons, J. Fung, and T. Starzl. 1999. Posttransplant lymphoproliferative disorders in adult and pediatric renal patients receiving tacrolimus-based immunosuppression. Transplantation 68:1851-1854.
33. Thorley-Lawson, D., and G. Babcock. 1999. A model for persistent infection with Epstein-Barr virus: the stealth virus of human B cells. Life Sci. 65:1433-1453.
34. Timms, J., A. Bell, J. Flavell, P. Murray, A. Rickinson, A. Traverse-Glehen, F. Berger, and H.-J. Delecluse. 2003. Target cells of Epstein-Barr-virus (EBV)-positive post-transplant lymphoproliferative disease: similarities to EBV-positive Hodgkin's lymphoma. Lancet 361:217-223.
35. Vajro, P., S. Lucariello, S. Migliarello, B. Gridelli, A. Vegnent, R. Iorio, F. Smets, I. Quinto, and G. Scala. 2000. Predictive value of Epstein-Barr virus genome copy number and BZLF1 expression in blood lymphocytes of transplant recipients at risk for lymphoproliferative disease. J. Infect. Dis. 181: 2050-2054.
36. Webber, S., and M. Green. 2000. Posttransplantation lymphoproliferative disorders: advances in diagnosis, prevention, and management in children. Prog. Pediatr. Cardiol. 11:145-157.
37. Yang, J, Q. Tao., I. Flinn, P. Murray, L. Post, H. Ma, S. Piantadosi, M. Caligiuri, and R. Ambinder. 2000. Characterization of Epstein-Barr virus-infected B cells in patients with posttransplantation lymphoproliferative disease: disappearance after rituximab therapy does not predict clinical response. Blood 96:4055-4063.
38. Zanghill, S., D. Hsu, M. Kickuk, J. Garvin, C. Stolar, J. Haddad Jr., S. Stylianos, R. Michler, A. Chadburn, D. Knowles, and L. Addonizio. 1998. Incidence and outcome of primary Epstein-Barr virus infection and lymphoproliferative disease in pediatric heart transplant recipients. J. Heart Lung Transplant. 17:1161-1166.