Carcinogenicity and chronic toxicity after inhalation exposure of rats and mice to N,N-dimethylformamide

Journal of Occupational Health

Volumn 46, Issue 6, 2004, Pages 429-439

  Senoh, Hideki ^a,b   Aiso, Shigetoshi ^a   Arito, Heihachiro ^a   Nishizawa, Tomoshi ^a   Nagano, Kasuke ^a   Yamamoto, Seigo ^a   Matsushima, Taijiro ^a  

^a Japan Bioassay Research Center   (Japan)

^b Japan Industrial Safety and Health Association   (Japan)

Author keywords

Carcinogen; Dimethylformamide; DMF; Hepatoblastoma; Inhalation; Liver; Mouse; Rat; Tumor

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; BIOCHEMICAL MARKER; CHOLESTEROL; CREATINE KINASE; GAMMA GLUTAMYLTRANSFERASE; LACTATE DEHYDROGENASE; N,N DIMETHYLFORMAMIDE; NITROGEN; PHOSPHOLIPID; TRIACYLGLYCEROL; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; CANCER INCIDENCE; CARCINOGENICITY; CHRONIC TOXICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEPATOBLASTOMA; INHALATION; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER CARCINOMA; LIVER WEIGHT; LONG TERM EXPOSURE; MALE; MOUSE; NONHUMAN; RAT; SURVIVAL;

ADMINISTRATION, INHALATION; ANIMALS; BODY WEIGHT; CARCINOMA, HEPATOCELLULAR; DIMETHYLFORMAMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LIVER; LIVER NEOPLASMS; MALE; MICE; RANDOM ALLOCATION; RATS; RATS, INBRED F344; TIME FACTORS;

ANIMALIA;

EID: 10844258025     PISSN: 13419145     EISSN: None     Source Type: Journal    
DOI: 10.1539/joh.46.429     Document Type: Article

References (34)

1. International Programme on Chemical Safety (IPCS). Environmental health criteria 114 Dimethylformamide. Geneva: WHO, 1991.
2. Chemical products handbook-14504. Tokyo: The Chemical Daily Co., 2004: 515-516 (in Japanese).
3. International Programme on Chemical Safety (IPCS). Concise international chemical assessment document No. 31, N,N-Diemthylformamide. Geneva: WHO, 2001: 12.
4. R Wrbitzky and J Angerer: N,N-Dimethylformamide influence of working conditions and skin penetration on the internal exposure of workers in synthetic textile production. Int Arch Occup Environ Health 71, 309-316 (1998)
5. JS Yang, EA Kim, MY Lee, IJ Park and SK Kang: Biological monitoring of occupational exposure to N,N-dimethylformamide-the effects of co-exposure to toluene or dermal exposure. Int Arch Occup Environ Health 73, 463-470 (2000)
6. LE Fleming, SL Shalat and CA Redlich: Liver injury in workers exposed to dimethylformamide. Scand J Work Environ Health 16, 289-292 (1990)
7. LD Wang, MY Lai, JS Chen, JM Lin, JR Chiang, SJ Shiau and WS Chang: Dimethylformamide-induced liver damage among synthetic leather workers. Arch Environ Health 46, 161-166 (1991)
8. CA Redlich, WS Beckett, J Sparer, KW Barwick, CA Riely, H Miller, SL Sigal, SL Shalat and MR Cullen: Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med 108, 680-686 (1988)
9. CA Redlich, AB West, L Fleming, LD True, MR Cullen and CA Riely: Clinical and pathological characteristics of hepatotoxicity associated with occupational exposure to dimethylformamide. Gastroenterology 99, 748-757 (1990)
10. A Fiorito, F Larese, S Molinari and T Zanin: Liver function alterations in synthetic leather workers exposed to dimethylformamide. Am J Ind Med 32, 255-260 (1997)
11. HP Potter: Dimethylformamide-induced abdominal pain and liver injury. Arch Environ Health 27, 340-341 (1973)
12. T Nomiyama, M Uehara, H Miyauchi, S Imamiya, S Tanaka and Y Seki: Causal relationship between a case of severe hepatic dysfunction and low exposure concentrations of N,N-dimethylformamide in the synthetics industry. Ind Health 39, 33-36 (2001)
13. 1 mice. Toxicol Sci 72, 347-358 (2003)
14. LA Malley, TW Slone Jr, C Van Pelt, GS Elliot, PE Ross, JC Stadler, GL Kennedy Jr: Chronic toxicity/oncogenicity of dimethylformamide in rats and mice following inhalation exposure. Fundam Appl Toxicol 23, 268-279 (1994)
15. H Senoh, T Katagiri, H Arito, T Nishizawa, K Nagano, S Yamamoto and T Matsushima: Toxicity due to 2- and 13-wk inhalation exposures of rats and mice to N,N-Dimethylformamide. J Occup Health 45, 365-375 (2003)
16. AM Ducatman, DE Conwill and J Crawl: Germ cell tumors of the testicle among aircraft repairmen. J Urol 136, 834-836 (1986)
17. SM Levin, DB Baker, PJ Landrigan, SV Monaghan, E Frumin, M Braithwaite and W Towne: Testicular cancer in leather tanners exposed to dimethylformamide. Lancet 2, 1153 (1987)
18. GM Calvert, JM Fajen, BW Hills and WE Halperin: Testicular cancer, dimethylformamide, and leather tanneries. Lancet 336, 1253-1254 (1990)
19. International Agency for Research on Cancer (IARC). Dimethylformamide. In: IARC monographs on the evaluation of carcinogenic risks to humans. Some organic solvents, resin monomers and related compounds, pigments and occupational exposures in paint manufacture and painting. IARC Monographs Vol. 47. Lyon: IARC, 1989: 171-197.
20. International Agency for Research on Cancer (IARC). Dimethylformamide. In: IARC monographs on the evaluation of carcinogenic risks to humans, re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide (Part Two). IARC monographs Vol. 71. Lyon: IARC, 1999: 545-574.
21. JL Chen, WE Fayerweather and S Pell: Cancer incidence of workers exposed to dimethylformamide and/or acrylonitrile. J Occup Med 30, 813-818 (1988)
22. J Walrath, WE Fayerweather, PG Gilby and S Pell: A case-control study of cancer among DuPont employees with potential for exposure to dimethylformamide. J Occup Med 31, 432-438 (1989)
23. Threshold Limit Values (TLVs) for chemical substances. TLVs and BEIs. Threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati: ACGIH, 2003: 28.
24. Japan Society for Occupational Health (JSOH): Recommendation of occupational exposure limits (2001-2002). J Occup Health 44, 208-222 (2002)
25. Organisation for Economic Co-operation and Development (OECD). OECD guideline for the testing of chemicals 453 (Combined chronic toxicity/carcinogenicity studies). Paris: OECD, 1981.
26. Organisation for Economic Co-operation and Development (OECD). Principles of good laboratory practice. Series on principles of good laboratory practice and compliance monitoring No. 1. ENV/MC/ CHEM (98) 17. Paris: OECD, 1998.
27. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, U.S.A. Guide for the care and use of laboratory animals. Washington DC: National Academy Press, 1996.
28. Peto R, Pike MC, Day NE, Gray RG, Lee PN, Parish S, Peto J, Richards S and Wahrendorf J. Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments. In: Long-term and short-term screening assays for carcinogens: a critical appraisal. IARC monographs, Suppl.2. Lyon: IARC, 1980: 311-426.
29. T Kasai, T Nishizawa, H Arito, K Nagano, S Yamamoto, T Matsushima and T Kawamoto: Acute and subchronic inhalation toxicity of chloroform in rats and mice. J Occup Health 44, 193-202 (2002)
30. Deschl U, Cattley RC, Harada T, Kutter K, Haley JR, Hartig F, Leblanc B, Marsman DS and Shirai T. Liver, gallbladder, and exocrine pancreas. In: Mohr U, ed. International classification of rodent tumors: The mouse. Berlin: Springer-Verlag, 2001: 59-86.
31. Frith CH, Ward JM and Turusov VS. Tumor of the liver. In: Pathology of tumors in laboratory animals. Tumors of the mouse Vol. II. IARC scientific publication. 111. Lyon: IARC, 1994: 223-269.
32. Bannasch P et al. Long-term assays for carcinogenicity in animals. In: Montesano R et al. eds. Long-term and short-term assays for carcinogens: A critical appraisal. IARC scientific publications No. 83. Lyon: IARC, 1986: 34-37.
33. Sontag JM, Page NP and Saffiotti U. Guidelines for carcinogen bioassay in small rodents. NCI-CG-TR-1. Washington DC: DHEW, 1976.
34. JK Haseman: Issues in carcinogenicity testing, dose selection. Fundam Appl Toxicol 5, 66-78 (1985)