Liver function alterations in synthetic leather workers exposed to dimethylformamide

American Journal of Industrial Medicine

Volumn 32, Issue 3, 1997, Pages 255-260

  Fiorito, Antonio ^a   Larese, Francesca ^a   Molinari, Stefania ^a   Zanin, Tina ^b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b Servizio di Medicina del Lavoro   (Italy)

Author keywords

Alcohol intake; Dimethylformamide; Hepatotoxicity; Leather workers; Occupational exposure; Skin absorption

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; DISULFIRAM; GAMMA GLUTAMYLTRANSFERASE; LIVER ENZYME; N METHYLFORMAMIDE; N,N DIMETHYLFORMAMIDE;

ADULT; ARTICLE; CONTROLLED STUDY; HUMAN; LEATHER INDUSTRY; LIVER DISEASE; LIVER FUNCTION; MAJOR CLINICAL STUDY; PREVALENCE; SYMPTOMATOLOGY; URINE LEVEL;

ADULT; AIR POLLUTANTS, OCCUPATIONAL; ANALYSIS OF VARIANCE; CHI-SQUARE DISTRIBUTION; CROSS-SECTIONAL STUDIES; DIMETHYLFORMAMIDE; HUMANS; ITALY; LIVER DISEASES; LIVER FUNCTION TESTS; LOGISTIC MODELS; MALE; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; STATISTICS, NONPARAMETRIC;

EID: 0030795395     PISSN: 02713586     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0274(199709)32:3<255::AID-AJIM11>3.0.CO;2-U     Document Type: Article

References (38)

1. ACGIH-TLV's threshold limit values and biological exposure indices for 1988-89. In "Indices Biologiques d'Exposition" (1989): Cah Not Doc, 134, ND 1710:51-56.
2. Anderson T, Christofferson P, Gluud C (1989): The liver in consecutive patients with morbid obesity: A clinical, morphological and biochemical study. Int J Obes 8:107-115.
3. Barnes JR, Henry NW (1974): The determination of N-methylformamide and N-methylacetamide in urine. Am Ind Hyg Assoc J 35:84-87.
4. Braillon A, Capron JP, Herve MA (1985): Liver in obesity. Gut 26:133-139.
5. Catenacci G, Ghittori S, Cottica D, Prestinoni A, Capodaglio E (1980): Occupational exposure to dimethylformamide and urinary excrection of monomethylformamide. G Ital Med Lav 2:53-57.
6. Cirla AM, Pisati G, Invernizzi E, Torricelli P (1984): Epidemiological study of workers exposed to low dimethylformamide concentrations. G Ital Med Lav 6:149-156.
7. Clayton JW, Barnes JR, Hood DR, Schepers GWH (1963): The inhalation toxicity of dimethylformamide. Am Ind Hyg Assoc J 24:144-154.
8. Diehel AM, Goodman Z, Ishak KG (1988): Alcohol-like liver disease in non-alcoholics. Gastroenterology 95:1056-1062.
9. Di Lorenzo F, Grazioli C (1972). Reperti ematologici, ematochimici e gastrologici in operai esposti all'inalazione di vapori di dimethylformamide. Lav Um 24:97-105.
10. Fiorito A, Gobbato F, Cipolla G, Volpe C (1979): Indagine clinico epidemiologica in 102 operai esposti a DMF in una fabbrica di finte pelli. Difesa Soc 2:68-72.
11. Fleming LE, Shalat SL, Redlich CA (1990): Liver injury in workers exposed to dimethylformamide. Scand J Work Environ Health 16:289-291.
12. Franco G, Fronte R, Tempini G, Candura F (1986): Serum bile concentrations as a liver function test in workers occupationally exposed to organic solvents. Int Arch Occup Environ Health 58:157-164.
13. Graig DK, Weir RJ, Wagner W, Groth D (1984): Subchronic inhalation toxicity of DMF in rats and mice. Drug Chem Toxicol 7:551-556.
14. Guzelian P, Mills S, Fallon HJ (1988): Liver structure and function in print workers exposed to toluene. J Occup Med 30:791-796.
15. Hogdson MJ, Van Thiel DH, Lauschus K, Karpf M (1989): Liver injury tests in hazardous waste workers: The role of obesity. J Occup Med 31:238-242.
16. Imbriani M, Ghittori S, Prestinoni A, Longoni P, Cascone G, Gamba G (1986):Effects of dimethylformamide on coagulation and platelet activity. Arch Environ Health 41:90-93.
17. Kennedy CL (1986): Biological effects of acetamide, formamide and their monomethyl and dimethyl derivatives. Crit Rev Toxicol 17:129-166.
18. Kittila RS (1965): Dimethylformamide chemical uses. DuPont de Nemours Co., Wilmington. DE; cited in Scailteur V, Lauwerys RR (1987): Dimethylformamide hepatotoxicity. Toxicology 43:231-238.
19. Kutsche A (1965): Zur toxikologie des demethylformamides. Arzneim Forsch 15:618-635.
20. Lauwerys RR, Kivits A, Lhoir M, Rigolet P, Houbeau D, Buchet JP, Roels HA (1980): Biological surveillance of workers exposed to dimethylformamide and the influence of skin protection on its percutaneous absorption. Int Arch Occup Environ Health 45:189-203.
21. Liss GM, Greenberg RA, Tamburro CH (1985): Use of serum bile acids in the identification of vinyl chloride hepatotoxicity. Am J Med 78:68-76.
22. Lundberg I, Lundberg S, Kronevi T (1981): Some observations on dimethylformamide hepatotoxicity. Toxicology 22:1-7.
23. Martelli D (1960): Tossicologia della dimetilformamide. Med Lav 51:123-128.
24. Massman W (1956): Toxicological investigations on dimethylformamide. Br J Ind Med 13:51-54.
25. Mathew T, Karunanithy R, Yee MH, Pharm BS, Natarajan PN (1980): Hepatotoxicity of dimethylformamide and dimethylsulfoxide at and above the levels used in some aflatoxin studies. Lab Invest 42:257-262.
26. Mraz J, Nahova H (1992): Percutaneous absorption of N,N-dimethylformamide in humans. Int Arch Occup Environ Health 64:79-83.
27. Potter HP (1973): Dimethylformamide-induced abdominal pain and liver injury. Arch Environ Health 27:340-341.
28. Redlich AC, Beckett SW, Sparer J, Barwick WK Riley CA, Miller H, Singal SL, Shalat SL, Cullen MR (1988): Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med 108:680-686.
29. Redlich CA, West AB, Fleming L, True LD, Cullen MR, Riely CA (1990): Clinical and pathological characteristics of hepatotoxicity associated with occupational exposure to dimethylformamide. Gastroenterology 99:748-757.
30. Reinl W, Urban HG (1965): Erkrankungen Durch Dimethylformamide. Int Arch Gewerbepathol Gewerbehyg 21:333-246.
31. Scailteur V, Lauwerys RR (1987): Dimethylformamide hepatotoxicity. Toxicology 43:231-238.
32. Tamburro CH, Liss GM (1986) Tests for hepatotoxicity: Usefulness in screening workers. J Occup Med 28:1034-1043.
33. Tolot F, Droin M, Genevois M (1958): Intoxication par la dimethylformamide. Arch Mal Prof 19:602-606.
34. Tolot F, Arcadio F, Lenglet JP, Roche L (1968): Intoxication par la dimethylformamide. Arch Mal Prof 29:714-717.
35. Tomasini R, Todaro A, Piazzoni M, Peruzzo GF (1983): Patologia da dimetilformamide: Osservazione su 14 casi. Med Lav 74:217-220.
36. Wang J, Lai MY (1991): Dimethylformamide-induced liver damage among synthetic leather workers. Arch Environ Health 46:161-165.
37. Wright C, Rivera JC, Baetz JH (1988): Liver function testing in a working population: three strategies to reduce false-positive results. J Occup Med 30:693-698.
38. Yonemoto J, Suzuki S (1980): Relation of exposure to dimethylformamide vapour and the metabolite, methylformamide, in urine of workers. Int Arch Occup Environ Health 46:159-165.