메뉴 건너뛰기




Volumn 29, Issue 11 SPEC. ISS., 2004, Pages 2057-2067

Metabolism of [U- 13C]leucine in cultured astroglial cells

Author keywords

Astrocytes; energy metabolism; leucine; metabolic compartmentation; NMR spectroscopy

Indexed keywords

2 OXOISOCAPROIC ACID; ACETYL COENZYME A; ALANINE; CITRIC ACID; GLUTAMINE; KETONE BODY; LACTIC ACID; LEUCINE; MALATE DEHYDROGENASE (DECARBOXYLATING); PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SUCCINIC ACID;

EID: 10844241455     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-004-6879-8     Document Type: Article
Times cited : (19)

References (48)
  • 1
    • 0031239010 scopus 로고    scopus 로고
    • Brain metabolism of branched-chain amino acids
    • Yudkoff, M. 1997. Brain metabolism of branched-chain amino acids. Glia 21:92-98.
    • (1997) Glia , vol.21 , pp. 92-98
    • Yudkoff, M.1
  • 3
    • 0017229985 scopus 로고
    • Leucine oxidation in brain slices and nerve endings
    • Chaplin, E. R., Goldberg, A. L., and Diamond, I. 1976. Leucine oxidation in brain slices and nerve endings. J. Neurochem. 26:710-717.
    • (1976) J. Neurochem. , vol.26 , pp. 710-717
    • Chaplin, E.R.1    Goldberg, A.L.2    Diamond, I.3
  • 4
    • 0028892038 scopus 로고
    • Generation of ketone bodies from leucine by cultured astroglial cells
    • Bixel, M. G. and Hamprecht, B. 1995. Generation of ketone bodies from leucine by cultured astroglial cells. J. Neurochem. 65:2450-2461.
    • (1995) J. Neurochem. , vol.65 , pp. 2450-2461
    • Bixel, M.G.1    Hamprecht, B.2
  • 8
    • 0029935376 scopus 로고    scopus 로고
    • Neuronal metabolism of branched-chain amino acids: Flux through the aminotransferase pathway in synaptosomes
    • Yudkoff, M., Daikhin, Y., Nelson, D., Nissim, I., and Erecinska, M. 1996. Neuronal metabolism of branched-chain amino acids: Flux through the aminotransferase pathway in synaptosomes. J. Neurochem. 66:2136-2145.
    • (1996) J. Neurochem. , vol.66 , pp. 2136-2145
    • Yudkoff, M.1    Daikhin, Y.2    Nelson, D.3    Nissim, I.4    Erecinska, M.5
  • 9
    • 0031007633 scopus 로고    scopus 로고
    • Cellular distribution of branched-chain amino acid aminotransferase isoenzymes among rat brain glial cells in culture
    • Bixel, M. G., Hutson, S. M., and Hamprecht, B. 1997. Cellular distribution of branched-chain amino acid aminotransferase isoenzymes among rat brain glial cells in culture. J. Histochem. Cytochem. 45:685-694.
    • (1997) J. Histochem. Cytochem. , vol.45 , pp. 685-694
    • Bixel, M.G.1    Hutson, S.M.2    Hamprecht, B.3
  • 10
    • 0013881117 scopus 로고
    • Transaminase of branched-chain amino acids. I. Branched-chain amino acids-α-ketoglutarate transaminase
    • Tokyo
    • Ichihara, A. and Koyama, E. 1966. Transaminase of branched-chain amino acids. I. Branched-chain amino acids-α-ketoglutarate transaminase. J. Biochem. (Tokyo) 59:160-169.
    • (1966) J. Biochem. , vol.59 , pp. 160-169
    • Ichihara, A.1    Koyama, E.2
  • 11
    • 0014149358 scopus 로고
    • Transaminase of branched-chain amino acids. III. Purification and properties of the mitochondrial enzyme from hog heart and comparison with the supernatant enzyme
    • Tokyo
    • Aki, K., Ogawa, K., Shirai, A., and Ichihara, A. 1967. Transaminase of branched-chain amino acids. III. Purification and properties of the mitochondrial enzyme from hog heart and comparison with the supernatant enzyme. J. Biochem. (Tokyo) 62:610-617.
    • (1967) J. Biochem. , vol.62 , pp. 610-617
    • Aki, K.1    Ogawa, K.2    Shirai, A.3    Ichihara, A.4
  • 12
    • 0024267856 scopus 로고
    • Subcellular distribution of branched-chain aminotransferase activity in rat tissues
    • Hutson, S. M. 1988. Subcellular distribution of branched-chain aminotransferase activity in rat tissues. J. Nutr. 118:1475-1481.
    • (1988) J. Nutr. , vol.118 , pp. 1475-1481
    • Hutson, S.M.1
  • 14
    • 0035116897 scopus 로고    scopus 로고
    • Distribution of key enzymes of branched-chain amino acid metabolism in glial and neuronal cells in culture
    • Bixel, M. G., Shimomura, Y., Hutson, S. M., and Hamprecht, B. 2001. Distribution of key enzymes of branched-chain amino acid metabolism in glial and neuronal cells in culture. J. Histochem. Cytochem. 49:407-418.
    • (2001) J. Histochem. Cytochem. , vol.49 , pp. 407-418
    • Bixel, M.G.1    Shimomura, Y.2    Hutson, S.M.3    Hamprecht, B.4
  • 15
    • 0346888682 scopus 로고    scopus 로고
    • Regulation of glia metabolism studied by C-13 NMR
    • Zwingmann, C. and Leibfritz, D. 2003. Regulation of glia metabolism studied by C-13 NMR. NMR Biomed. 16:370-399.
    • (2003) NMR Biomed. , vol.16 , pp. 370-399
    • Zwingmann, C.1    Leibfritz, D.2
  • 16
    • 0021893839 scopus 로고
    • Primary glial cultures as a model for studying hormone action
    • Hamprecht, B. and Löffler, F. 1985. Primary glial cultures as a model for studying hormone action. Meth. Enzymol. 109:341-345.
    • (1985) Meth. Enzymol. , vol.109 , pp. 341-345
    • Hamprecht, B.1    Löffler, F.2
  • 17
    • 0025247999 scopus 로고
    • Purification of glycogen phosphorylase from bovine brain and immunocytochemical examination of rat glial primary cultures using monoclonal antibodies raised against this enzyme
    • Reinhart, P. H., Pfeiffer, B., Spengler, S., and Hamprecht, B. 1990. Purification of glycogen phosphorylase from bovine brain and immunocytochemical examination of rat glial primary cultures using monoclonal antibodies raised against this enzyme. J. Neurochem. 54:1474-1483.
    • (1990) J. Neurochem. , vol.54 , pp. 1474-1483
    • Reinhart, P.H.1    Pfeiffer, B.2    Spengler, S.3    Hamprecht, B.4
  • 18
    • 84989076126 scopus 로고
    • Gradient selection in inverse heteronuclear correlation spectroscopy
    • Willker, W., Leibfritz, D., Kerssebaum, R., and Bermel W. 1993. Gradient selection in inverse heteronuclear correlation spectroscopy. Magn. Reson. Chem. 31:287-292.
    • (1993) Magn. Reson. Chem. , vol.31 , pp. 287-292
    • Willker, W.1    Leibfritz, D.2    Kerssebaum, R.3    Bermel, W.4
  • 19
    • 10844245152 scopus 로고
    • An efficient windowless sequence for broadband heteronuclear decoupling
    • Sunitha Bai, N., Hari N., and Ramachandran R. 1994. An efficient windowless sequence for broadband heteronuclear decoupling. J. Magn. Reson. A106:241-244.
    • (1994) J. Magn. Reson. , vol.A106 , pp. 241-244
    • Sunitha Bai, N.1    Hari, N.2    Ramachandran, R.3
  • 20
    • 0002455590 scopus 로고    scopus 로고
    • Metabolite identification in cell extracts and culture media by proton-detected 2D-H,C-NMR spectroscopy
    • Willker, W., Engelmann, J., Brand, A., and Leibfritz D. 1996. Metabolite identification in cell extracts and culture media by proton-detected 2D-H,C-NMR spectroscopy. J. Magn. Reson. Anal. 2:21-32.
    • (1996) J. Magn. Reson. Anal. , vol.2 , pp. 21-32
    • Willker, W.1    Engelmann, J.2    Brand, A.3    Leibfritz, D.4
  • 21
    • 1842289372 scopus 로고
    • Identification of pyro-glutamate and glucosyl-aminoacids in cell culture media
    • Willker, W., Engelmann, J., Brand, A. and Leibfritz D. 1995. Identification of pyro-glutamate and glucosyl-aminoacids in cell culture media. J. Magn. Reson. Anal. 1:20-24.
    • (1995) J. Magn. Reson. Anal. , vol.1 , pp. 20-24
    • Willker, W.1    Engelmann, J.2    Brand, A.3    Leibfritz, D.4
  • 22
    • 0032127127 scopus 로고    scopus 로고
    • Characterization of the monocarboxylate transporter, expressed in xenopus laevis oocytes by changes in cytosolic pH
    • Bröer, S., Schneider, H.-P., Bröer, A., Rahman, B., Hamprecht, B., and Deitmer, J. W. 1998. Characterization of the monocarboxylate transporter, expressed in xenopus laevis oocytes by changes in cytosolic pH. Biochem. J. 333:167-174.
    • (1998) Biochem. J. , vol.333 , pp. 167-174
    • Bröer, S.1    Schneider, H.-P.2    Bröer, A.3    Rahman, B.4    Hamprecht, B.5    Deitmer, J.W.6
  • 23
    • 0028966538 scopus 로고
    • Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase
    • Cesar, M. and Hamprecht, B. 1995. Immunocytochemical examination of neural rat and mouse primary cultures using monoclonal antibodies raised against pyruvate carboxylase. J. Neurochem. 64:2312-2318.
    • (1995) J. Neurochem. , vol.64 , pp. 2312-2318
    • Cesar, M.1    Hamprecht, B.2
  • 24
    • 0021988603 scopus 로고
    • Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools
    • Shank, R. P., Bennett, G. S., Freytag, S. O., and Campbell, G. 1985. Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools. Brain Res. 329:364-367.
    • (1985) Brain Res. , vol.329 , pp. 364-367
    • Shank, R.P.1    Bennett, G.S.2    Freytag, S.O.3    Campbell, G.4
  • 25
    • 0027465673 scopus 로고
    • Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in glial cells of neural primary cultures
    • Kurz, G. M., Wiesinger, H., and Hamprecht, B. 1993. Purification of cytosolic malic enzyme from bovine brain, generation of monoclonal antibodies, and immunocytochemical localization of the enzyme in glial cells of neural primary cultures. J. Neurochem. 60:1467-1474.
    • (1993) J. Neurochem. , vol.60 , pp. 1467-1474
    • Kurz, G.M.1    Wiesinger, H.2    Hamprecht, B.3
  • 26
    • 0028819598 scopus 로고
    • Significant amounts of glycogen are synthesized from 3-carbon compounds in astroglial primary cultures from mice with participation of the mitochondrial phosphoenolpyruvate carboxykinase isoenzyme
    • Schmoll, D., Führmann, E., Gebhardt, R., and Hamprecht, B. 1995. Significant amounts of glycogen are synthesized from 3-carbon compounds in astroglial primary cultures from mice with participation of the mitochondrial phosphoenolpyruvate carboxykinase isoenzyme. Eur. J. Biochem. 227:308-315.
    • (1995) Eur. J. Biochem. , vol.227 , pp. 308-315
    • Schmoll, D.1    Führmann, E.2    Gebhardt, R.3    Hamprecht, B.4
  • 28
    • 0027787059 scopus 로고
    • 13C]D-glucose metabolism in cultured astrocytes and neurons using nuclear magnetic resonance spectroscopy
    • 13C]D-glucose metabolism in cultured astrocytes and neurons using nuclear magnetic resonance spectroscopy. Dev. Neurosci. 15:282-288.
    • (1993) Dev. Neurosci. , vol.15 , pp. 282-288
    • Leo, G.C.1    Driscoll, B.F.2    Shank, R.P.3
  • 29
    • 0028256181 scopus 로고
    • Uptake, release, and metabolism of citrate in neurons and astrocytes in primary cultures
    • Westergaard, N., Sonnewald, U., Unsgard, G., Peng, L., Hertz, L., and Schousboe, A. 1994. Uptake, release, and metabolism of citrate in neurons and astrocytes in primary cultures. J. Neurochem. 62:1727-1733.
    • (1994) J. Neurochem. , vol.62 , pp. 1727-1733
    • Westergaard, N.1    Sonnewald, U.2    Unsgard, G.3    Peng, L.4    Hertz, L.5    Schousboe, A.6
  • 30
    • 0028167909 scopus 로고
    • Release of α-ketoglutarate, malate and succinate from cultured astrocytes: Possible role in amino-acid neurotransmitter homeostasis
    • Westergaard, N., Sonnewald, U., and Schousboe, A. 1994. Release of α-ketoglutarate, malate and succinate from cultured astrocytes: possible role in amino-acid neurotransmitter homeostasis. Neurosci. Lett. 176:105-109.
    • (1994) Neurosci. Lett. , vol.176 , pp. 105-109
    • Westergaard, N.1    Sonnewald, U.2    Schousboe, A.3
  • 31
    • 0027216810 scopus 로고
    • Glycogen in astrocytes: Possible function as lactate supply for neighbouring cells
    • Dringen, R., Gebhardt, R., and Hamprecht, B. 1993. Glycogen in astrocytes: possible function as lactate supply for neighbouring cells. Brain Res. 623:208-214.
    • (1993) Brain Res. , vol.623 , pp. 208-214
    • Dringen, R.1    Gebhardt, R.2    Hamprecht, B.3
  • 32
    • 0026615180 scopus 로고
    • 13C NMR study on fluxes into the TCA cycle of neuronal and glial tumor cell lines and primary cells
    • 13C NMR study on fluxes into the TCA cycle of neuronal and glial tumor cell lines and primary cells. Biochimie 74:941-948.
    • (1992) Biochimie , vol.74 , pp. 941-948
    • Brand, A.1    Engelmann, J.2    Leibfritz, D.3
  • 33
    • 0027749707 scopus 로고
    • Multinuclear NMR studies on the energy metabolism of glial and neuronal cells
    • Brand, A., Richter-Landsberg, C., and Leibfritz, D. 1993. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev. Neurosci. 15:289-298.
    • (1993) Dev. Neurosci. , vol.15 , pp. 289-298
    • Brand, A.1    Richter-Landsberg, C.2    Leibfritz, D.3
  • 34
    • 0023408979 scopus 로고
    • Acute effect of ammonia on branched-chain amino acid oxidation and incorporation into protein in astrocytes and in neurons in primary cultures
    • Murthy, C. R. K. and Hertz, L. 1987. Acute effect of ammonia on branched-chain amino acid oxidation and incorporation into protein in astrocytes and in neurons in primary cultures. J. Neurochem. 49:735-742.
    • (1987) J. Neurochem. , vol.49 , pp. 735-742
    • Murthy, C.R.K.1    Hertz, L.2
  • 35
    • 0035346949 scopus 로고    scopus 로고
    • Is there an astrocyte-neuron ketone body shuttle?
    • Guzman, M. and Blazquez, C. 2001. Is there an astrocyte-neuron ketone body shuttle? Trends Endocrinol. Metab. 12:169-173.
    • (2001) Trends Endocrinol. Metab. , vol.12 , pp. 169-173
    • Guzman, M.1    Blazquez, C.2
  • 36
    • 0002200343 scopus 로고
    • Energy metabolism
    • Kettenmann H. and Ransom, B., (eds.), Oxford University Press, New York
    • Hamprecht, B. and Dringen, R. 1995. Energy metabolism. Pages 473-487, in Kettenmann H. and Ransom, B., (eds.), Neuroglial Cells, Oxford University Press, New York.
    • (1995) Neuroglial Cells , pp. 473-487
    • Hamprecht, B.1    Dringen, R.2
  • 38
    • 0026020414 scopus 로고
    • Fatty acid oxidation and ketogenesis by astrocytes in primary culture
    • Auestad, N., Korsak, R. A., Morrow, J. W., and Edmond, J. 1991. Fatty acid oxidation and ketogenesis by astrocytes in primary culture. J. Neurochem. 56:1376-1386.
    • (1991) J. Neurochem. , vol.56 , pp. 1376-1386
    • Auestad, N.1    Korsak, R.A.2    Morrow, J.W.3    Edmond, J.4
  • 39
    • 0018970005 scopus 로고
    • Localization of hexokinase in neural tissue: Electron microscopic studies of rat cerebellar cortex
    • Kao-Jen, J. and Wilson, J. E. 1980. Localization of hexokinase in neural tissue: Electron microscopic studies of rat cerebellar cortex. J. Neurochem. 35:667-678.
    • (1980) J. Neurochem. , vol.35 , pp. 667-678
    • Kao-Jen, J.1    Wilson, J.E.2
  • 40
    • 0018887740 scopus 로고
    • Localization of hexokinase in neural tissue: Immunofluorescence studies on the developing cerebellum and retina of the rat
    • Simura, M. and Wilson, J. E. 1980. Localization of hexokinase in neural tissue: Immunofluorescence studies on the developing cerebellum and retina of the rat. J. Neurochem. 35:58-66.
    • (1980) J. Neurochem. , vol.35 , pp. 58-66
    • Simura, M.1    Wilson, J.E.2
  • 41
    • 0020696361 scopus 로고
    • Relative levels of hexokinase in isolated neuronal, astrocytic and oligodendroglial fractions from rat brain
    • Snyder, C. D. and Wilson, J. E. 1983. Relative levels of hexokinase in isolated neuronal, astrocytic and oligodendroglial fractions from rat brain. J. Neurochem. 40:1178-1181.
    • (1983) J. Neurochem. , vol.40 , pp. 1178-1181
    • Snyder, C.D.1    Wilson, J.E.2
  • 42
    • 0021364723 scopus 로고
    • The distribution of hexokinase compared to cytochrome oxidase and acetylcholinesterase in the somatosensory cortex and the superior colliculus of the rat
    • Sandell, J. H. 1984. The distribution of hexokinase compared to cytochrome oxidase and acetylcholinesterase in the somatosensory cortex and the superior colliculus of the rat. Brain Res. 290:384-389.
    • (1984) Brain Res. , vol.290 , pp. 384-389
    • Sandell, J.H.1
  • 43
    • 0023849707 scopus 로고
    • A possible contribution by glial cells to neuronal energy production: Enzyme-histochemical studies in the developing rat cerebellum
    • Katoh-Semba, R., Keino, H., and Kashiwamata, S. 1988. A possible contribution by glial cells to neuronal energy production: enzyme-histochemical studies in the developing rat cerebellum. Cell Tissue Res. 252:133-139.
    • (1988) Cell Tissue Res. , vol.252 , pp. 133-139
    • Katoh-Semba, R.1    Keino, H.2    Kashiwamata, S.3
  • 44
    • 0033981702 scopus 로고    scopus 로고
    • Immunocytochemical location of β-methylcrotonyl-CoA carboxylase in astroglial cells and neurons in culture
    • Bixel, M. G. and Hamprecht, B. 2000. Immunocytochemical location of β-methylcrotonyl-CoA carboxylase in astroglial cells and neurons in culture. J. Neurochem. 74:1059-1067.
    • (2000) J. Neurochem. , vol.74 , pp. 1059-1067
    • Bixel, M.G.1    Hamprecht, B.2
  • 46
    • 0033929168 scopus 로고    scopus 로고
    • Role of alanine for ammonia transfer between astrocytes and glutamatergic neurons
    • Waagepetersen, H. S., Sonnewald, U., Larsson, O. M., and Schousboe, A. 2000. Role of alanine for ammonia transfer between astrocytes and glutamatergic neurons. J. Neurochem. 75:471-479.
    • (2000) J. Neurochem. , vol.75 , pp. 471-479
    • Waagepetersen, H.S.1    Sonnewald, U.2    Larsson, O.M.3    Schousboe, A.4
  • 47
    • 0033673044 scopus 로고    scopus 로고
    • 13C] alanine in astrocytes, neurons, and co-cultures: Implications for glia-neuron interactions in neurotransmitter metabolism
    • 13C]alanine in astrocytes, neurons, and co-cultures: implications for glia-neuron interactions in neurotransmitter metabolism. Glia 32:286-303.
    • (2000) Glia , vol.32 , pp. 286-303
    • Zwingmann, C.1    Richter-Landsberg, C.2    Brand, A.3    Leibfritz, D.4
  • 48
    • 0034744108 scopus 로고    scopus 로고
    • 13C isotopomer analysis on glucose and alanine metabolism reveals cytosolic pyruvate compartmentation as part of energy metabolism in astrocytes
    • 13C isotopomer analysis on glucose and alanine metabolism reveals cytosolic pyruvate compartmentation as part of energy metabolism in astrocytes. Glia 34:200-212.
    • (2001) Glia , vol.34 , pp. 200-212
    • Zwingmann, C.1    Richter-Landsberg, C.2    Leibfritz, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.